Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds

Chemical Constituents and Biological Activities of <i>Zanthoxylum limonella</i> (Rutaceae): A Review

“…The phytochemical analysis of the dichloromethane extract of the stem of Z. limonella showed novel quinolone alkaloid, 4-methoxy-3-(3-methyl-2-oxobut-3-enyl)quinolin-2(1H)-one, limonellone (1) including five known compounds such as lignan: ()-asarinin (2), two aromatic amides: dihydroalatamide (3) and ()-tembamide (4), a furoquinoline alkaloid: dictamnine (5), and a benzophenanthridine alkaloid: N-nornitidine (6) (Fig 3). Additionally, the structure of these isolated compounds were also identified by 1 H, 13 C nuclear magnetic resonance (NMR) spectroscopy, chromatography, and melting points with corresponding authentic samples or literature data [27].…”

“…Phytochemical survey of this family reveals alkaloids, coumarins, flavonoids, limonoids, and volatile oils [4]. Many of these compounds have been associated to different biological activities, for example, antimicrobial [3,5], antidiarrhoeal [6], anticholinesterasic [7], antileishmanial [8], antiprotozoal [9], larvicidal [10,11], and antioxidant activities [12,13]. In family Rutaceae, the genus Zanthoxylum has been able to provide a variety of secondary metabolites with interesting phytochemical and biological activities [14].…”

Anti-Inflammatory Effect of 3-Methylcarbazoles on RAW 264.7 Cells Stimulated with LPS, Polyinosinic-Polycytidylic Acid and Pam3CSK

“…Although there are many carbazole alkaloid derivatives that have special ability to scavenge reactive oxygen species-free radicals, such as hydroxyl radicals, superoxide radicals, or hypochlorous acid, and to influence processes involving free-radical injury [22,23], they have also been found to inhibit lipid peroxidation and to possess vasorelaxant [24][25][26] and anti-inflammatory/antioxidant activity [20]. Moreover they have been reported for their other pharmacological activities such as anticancer [27], antidiarrhoeal [28], antidiabetic [29], antiasthmatic [30], antiplasmodial [31], antibacterial, antifungal and anthelmintic activities [32].…”

Antinociceptive, antidiarrheal, and neuropharmacological activities ofBarringtonia acutangula

“…Tannins may impart antidiarrheal effect possibly by inhibiting the intestinal motility (Gálvez et al, 1991) and reducing the intestinal secretion (Mukherjee et al, 1995). It may be possible that the antidiarrheal activity is due to the tannins (Agunu et al, 2005), alkaloids (Mandal et al, 2010), glycosides (Abere et al, 2010), and other phytoconstituents.…”