Antidiarrheal activity of ethanolic bark extract of Mitragyna diversifolia

Jebunnessa, Dr.; Uddin, Shaikh Bokhtear; Mahabub-Uz-Zaman, M.; Akter, Rasheda; Ahmed, N. U.

doi:10.3329/bjp.v4i2.2801

Cited by 22 publications

(17 citation statements)

References 5 publications

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“…The method as described by Jebunnessa et al [3] was used to evaluate anti-diarrheal activity of the plant extract. Twenty mice were divided into four groups of five animals in each.…”

Section: Anti-diarrheal Activity: Castor Oil-induced Diarrhea In Micementioning

confidence: 99%

“…Therefore, development of newer, more powerful and relatively cheap anti-inflammatory and analgesic drugs with lesser side effects is necessary for human welfare. Diarrhea is another common disease in developing countries especially in children and is responsible for the death of millions of people each year [3] . Medicinal plants are a gifted source especially for anti-diarrheal drugs [4] .…”

Section: Introductionmentioning

confidence: 99%

“…Medicinal plants are a gifted source especially for anti-diarrheal drugs [4] . For this motive, to combat the problem of diarrhea in developing countries, the World Health Organization in its Diarrheal Disease Control programme has encouraged to use traditional folklore medicines in the treatment and prevention [3,5] . Typhonium trilobatum (L.) (T. trilobatum) Schott belongs to the family Araceae, is a small to moderate sized perennial herb, commonly known as Bengal arum, Ghatkanchu or Ghatkol in Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

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Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott

Ali

Ashraf

Biswas

2012

Asian Pacific Journal of Tropical Biomedicine

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“…The method as described by Jebunnessa et al [3] was used to evaluate anti-diarrheal activity of the plant extract. Twenty mice were divided into four groups of five animals in each.…”

Section: Anti-diarrheal Activity: Castor Oil-induced Diarrhea In Micementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott

Ali

Ashraf

Biswas

2012

Asian Pacific Journal of Tropical Biomedicine

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“…Apart from the ease of accessibility, efficacy and affordability, formulations from such plants are also fast acting with minimal side effects (Joshi & Kaul 2001). However, most of these studies were conducted in West Africa (Meite et al 2009;Akuodor et al 2011;Awe et al 2011;Ezeja et al 2012) and Asia (Mukherjee et al 1998;Das et al 1999;Jebunnessa et al 2009;Saralaya et al 2010;Patil et al 2012). There is little information in literature on the laxative potential of medicinal plants from South African origin, particularly those from the eastern Free State Province.…”

Section: Introductionmentioning

confidence: 99%

Toxicological implications and laxative potential of ethanol root extract ofMorella serratain loperamide-induced constipated Wistar rats

Sabiu

Ashafa

2016

Pharmaceutical Biology

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Context: Morella serrata L. (Myricaceae) is commonly used in South Africa to treat several diseases including constipation. Objectives: This study investigated toxicological implications and laxative potential of the ethanol root extract of the plant. Materials and methods: While normal control animals were placed on sterile placebo, the loperamideconstipated rats were treated with the extract at 75, 150 and 300 mg/kg doses for 7 days, and their feeding patterns and faecal properties were monitored. Gastrointestinal transit ratio and the toxicity profile of the tested doses were thereafter evaluated. Results: The significantly increased faecal volume (192.08%), feed (63.63%), water intake (55.97%) and improved intestinal motility (95.05%) in the constipated rats following treatment with the extract (at 300 mg/kg) suggested laxative potential of the extract. The 1.5-2.0-fold normalization of the platelets, erythrocytes and leukocytes counts in the extract-treated constipated rats suggests its non-haematotoxic tendency. Furthermore, the extract (at the highest investigated dose) reversed the attenuation in the concentrations of the electrolytes (0.5-2-fold), total protein (62.12%) and albumin (55.88%) in the constipated animals as well as attenuated activities of hepatic enzymes (0.5-3.0-fold) and levels of urea (126.67%), creatinine (40.32%), cholesterol (3-fold) and triglycerides (9-fold). These further support its non-toxic and therapeutic attributes against constipation. Conclusion: Overall, the effect exhibited by M. serrata in this study competed well with Senokot (standard drug) and proved that it may be relatively safe and with excellent laxative potential, thus, supporting its pharmacological applications in South Africa. ARTICLE HISTORY

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“…The in vivo antidiarrheal activity of the extract was investigated following the methods previously described (Awouters et al, 1978;Jebunnessa et al, 2009;Shah et al, 2010). In the present study BALB-c albino mice were fasted for 18 hours.…”

Section: Antidiarrheal Protocolmentioning

confidence: 99%

Antidiarrheal and antispasmodic activities of Vincetoxicum stocksii are mediated through calcium channel blockade

Shah

Zaidi

Hassan

et al. 2011

Bangladesh J Pharmacol

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This study describes the antidiarrheal and antispasmodic activities of the crude extract of V. stocksii with possible mode of action explored. Materials and Methods Plant materialsAerial parts of V. stocksii (800 g) were obtained from Quetta Baluchistan and authenticated by Prof. Musaddar A Zaidi. A voucher specimen (VT-LF-09-02-57) was deposited at the herbarium located at the Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. Preparation of crude extractPreparation of the crude extract was carried out as described previously (Gilani et al., 2005). The powdered material was soaked in 70% aqueous-methanol for three AbstractThis study was carried out to explore the mechanism underlying antidiarrheal and antispasmodic activities of Vincetoxicum stocksii. The crude extract of V. stocksii provided 12-24% protection from castor oil-induced diarrhea at the dose of 300-1,000 mg/kg, similar to loperamide. In isolated rabbit jejunum preparations, V. stocksii caused inhibition of the spontaneous and high K + (80 mM)-induced contractions, with respective EC50 values of 2.5 (1.7-3.9) and 1.0 mg/mL (0.6-1.4), similar to that caused by verapamil, suggesting the calcium channel blocking effect. Loperamide caused inhibition of spontaneous and high K + -induced contraction, with respective EC50 values of 8.6 (6.3-10.1) and 9.1 µM (7.3-12.8). The calcium channel blocking activity was further confirmed when pretreatment of the tissues with V. stocksii (1-3 mg/mL) caused a rightward displacement of the Ca ++ concentrations response curves, similar to that produced by verapamil; constructed in Ca ++ free medium. These data indicate that the crude extract of V. stocksii contains calcium channel blocking constituents that may possibly explain its medicinal use in hyperactive states of gut, such as, diarrhea and spasms. Article Info

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Antidiarrheal activity of ethanolic bark extract of Mitragyna diversifolia

Cited by 22 publications

References 5 publications

Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott

Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott

Toxicological implications and laxative potential of ethanol root extract ofMorella serratain loperamide-induced constipated Wistar rats

Antidiarrheal and antispasmodic activities of Vincetoxicum stocksii are mediated through calcium channel blockade

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