2011
DOI: 10.3329/bjp.v6i1.8403
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Antidiarrheal and antispasmodic activities of Vincetoxicum stocksii are mediated through calcium channel blockade

Abstract: This study describes the antidiarrheal and antispasmodic activities of the crude extract of V. stocksii with possible mode of action explored. Materials and Methods Plant materialsAerial parts of V. stocksii (800 g) were obtained from Quetta Baluchistan and authenticated by Prof. Musaddar A Zaidi. A voucher specimen (VT-LF-09-02-57) was deposited at the herbarium located at the Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. Preparation of crude extractPreparation of t… Show more

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Cited by 21 publications
(21 citation statements)
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References 15 publications
(18 reference statements)
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“…The spontaneous intestinal movements are regulated through periodic depolarization and repolarization and at the height of depolarization, the action potential appears as a rapid influx of Ca 2þ via voltage-dependent channels (Brading 1981). Our previous observations on medicinal plants showed that the spasmolytic activity present in different plant extract was mediated through a CCB-like effect (Shah et al 2010(Shah et al , 2011. Thus, the partial inhibitory effect of Gt.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The spontaneous intestinal movements are regulated through periodic depolarization and repolarization and at the height of depolarization, the action potential appears as a rapid influx of Ca 2þ via voltage-dependent channels (Brading 1981). Our previous observations on medicinal plants showed that the spasmolytic activity present in different plant extract was mediated through a CCB-like effect (Shah et al 2010(Shah et al , 2011. Thus, the partial inhibitory effect of Gt.…”
Section: Discussionmentioning
confidence: 99%
“…Previously, the crude extracts provided protection from diarrhea in castor oil-induced diarrheal model, similar to verapamil (Godfraind et al 1986;Shah et al 2011). Hydrolysis of castor oil result in formation of recinoleic acid, which is responsible for the alteration of the transport of water and electrolytes and results in a hypersecretory response and the generation of a giant contraction of the intestine and ultimately the induction of diarrhea (Iwao & Terada 1962).…”
Section: Discussionmentioning
confidence: 99%
“…For example, V. rossicum (Kleopow) Barbar contains potent inhibitors of pathogenic fungi and bacteria (7). The n-hexane and ethyl acetate fractions of V. stocksii Ali and Khatoon were seen to exhibit anti-leishmanial activity against Leishmania donovani promastigotes (8,9). These extracts were also found to be active against Candida albicans, Bacillus subtilis, and B. cereus (10).…”
Section: Introductionmentioning
confidence: 93%
“…These extracts were also found to be active against Candida albicans, Bacillus subtilis, and B. cereus (10). A crude extract of V. stocksii was found to combat hyperactive states of the gut (9). Additionally, constituents in V. lutea L. were shown to possess anti-oxidant and radical scavenging activities (11).…”
Section: Introductionmentioning
confidence: 99%
“…The isolated tissue experiments were carried out as previously described (Gilani et al, 2005;Shah et al, 2011b). The animals had free access to water but were fasted for 24 h before the experiment.…”
Section: Isolated Tissue Preparationsmentioning
confidence: 99%