Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott

Ali, Khadem; Ashraf, Ayesha; Biswas, Nripendra Nath

doi:10.1016/s2221-1691(12)60217-2

Cited by 27 publications

(14 citation statements)

References 17 publications

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“…1) activity comparable to ascorbic acid (standard). The intensity of decline in absorbance indicates the power of scavenging activity which was seen in case of the extract (Ali et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Bioactivities of Aeschynomene aspera (Fabaceae) Leaf Extract

et al. 2020

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Aeschynomene aspera (Family- Fabaceae), a traditionally used medicinal plant, is aquatic, perennial, erect subshrub up to 200 cm tall with compound leaves and locally it is called Shola (Bangladesh), Laugaun (India). The study started with phytochemical screening of ethanolic leaf extract of A. aspera followed by bioactivity study such as in-vitro antioxidant activity by free radical (DPPH) scavenging assay, estimation of total phenolic as well as total flavonoid contents and the analgesic, antidiarrheal and anthelmintic activities. Analgesic, antidiarrheal and anthelmintic activities were evaluated by acetic acid induced writhing inhibition in mice, castor oil induced diarrheal episode in mice and using living parasites Haemonchus contortus, respectively. The presence of carbohydrate, reducing sugar, glycosides, tannins, alkaloids, steroids, gums and flavonoids was estimated with the help of phytochemical screening. In DPPH scavenging assay the extract showed IC50 value of 86.14μg/mL where ascorbic acid showed 12.02μg/mL. It also exhibited total phenolic and flavonoid contents as 461.09 GAE/100g and 297.20mg Quercetin/100g of dried plant extract. About 36% and 61% writhing inhibitions were observed in mice at 250 and 500mg/kg doses of A. aspera leaf extract, respectively. Anthelmintic activity showed by the extract was dose dependent. The extract also showed 46.01 and 71.68% inhibition of defecation in mice at doses 250 and 500 mg/kg, respectively. All these suggest that the A. aspera extract possesses antioxidant, analgesic, anthelmintic and antidiarrheal activities. Bangladesh Pharmaceutical Journal 23(2): 109-116, 2020

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Section: Resultsmentioning

confidence: 99%

Bioactivities of Aeschynomene aspera (Fabaceae) Leaf Extract

et al. 2020

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“…2 Some people use this herb as a native medicine for its anti-inflammatory, analgesic, and antidiarrheal properties. 3 To the best of our knowledge, poisoning due to ingestion of T. trilobatum is not reported in the literature till date. We present the first case series of T. trilobatum tuber poisoning manifesting with a toxidrome of painful pricking sensation of oral cavity, swelling of lips and tongue, increased salivation, drooling of saliva, upper airway angioedema, and airway compromise.…”

Section: Introductionmentioning

confidence: 98%

The First Case Series Report of Typhonium trilobatum Tuber Poisoning in Humans

Anandhi

Raju

Pillai

et al. 2020

Indian Journal of Critical Care Medicine

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A bstract Typhonium is a genus belonging to the Araceae family, native to southern Asia and Australia. In folk medicine, Typhonium is used for its analgesic, anti-inflammatory, antidiarrheal, and wound-healing properties. We report a toxidrome of airway compromise due to Typhonium trilobatum tuber ingestion. We present an interesting case series of four patients who consumed raw tuber of T. trilobatum with suicidal thoughts. They exhibited a constellation of symptoms such as swelling of lips and tongue, drooling of saliva, and severe throat pain. One patient had significant upper airway edema and severe respiratory distress requiring emergency endotracheal intubation. Laboratory investigations were grossly normal in all four individuals, expect for mild asymptomatic hypokalemia in one and eosinophilia in another patient. We successfully managed all our patients with repeated adrenaline nebulization, antihistamines, and steroids. Typhonium is believed to be a beneficial herb. Toxicity of Typhonium is not reported much in the literature till date. An emergency department (ED) physician should be aware of this tuber toxicity as it presents with airway compromise, which resolves over hours. The symptoms are due to the local effects of calcium oxalate crystals in the tuber. Airway management is the priority and repeated adrenaline nebulization together with supportive care is advised. How to cite this article Anandhi D, Prakash Raju KNJ, Vivekanandan MP, Kumaresan V. The First Case Series Report of Typhonium trilobatum Tuber Poisoning in Humans. Indian J Crit Care Med 2020;24(7):581–584.

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“…Medicinal uses of this plant have been described well in both Unani and Ayurvedic systems of medicine. Scientific investigations revealed that the plant has antimicrobial, antioxidant, anti-inflammatory, and nematocidal activities (Halder et al, 2011;Kandhasamy et al, 2008;Chattopaddhyay et al, 1989;Ali et al, 2012). Given the ethnomedicinal uses of this plant, we have undertaken to evaluate the acetylcholinesterase inhibitory activity and antioxidant property of the extracts from T. trilobatum.…”

Section: Introductionmentioning

confidence: 99%

Typhonium trilobatum Demonstrates Both Antioxidant and Acetylcholinesterase Inhibitory Activities In vitro

et al. 2019

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the elderly people. Cholinergic dysfunction and oxidative stress have been found to be related with the development of the disease. Typhonium trilobatum L. Scott has been used traditionally in folk medicine as a central nervous system stimulant. In this study, we have investigated the various extracts of T. trilobatum for acetylcholinesterase and antioxidant activities in vitro. All the tested extracts exhibited inhibition against acetylcholinesterase. Petroleum ether extract exhibited the highest inhibition with an IC50 of 255.26 g/ml. Likewise all the extracts were found to possess antioxidant activity. In reducing power assay, petroleum ether extract showed the highest reducing power with an absorbance of 0.874 at 0.1 mg/ml concentration and in DPPH radical scavenging assay, chloroform extract exhibited the highest scavenging activity with an IC50 of 619.54 µg/ml. Phytochemical analyses of the four extracts revealed that the ethyl acetate extract contained the highest amount of flavonoids and petroleum ether had the highest amount of phenolics. These results suggest that T. trilobatum has both antioxidant and cholinesterase inhibitory activities, which may be useful in reducing the risk of AD. Bangladesh Pharmaceutical Journal 22(1): 92-98, 2019

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Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott

Cited by 27 publications

References 17 publications

Bioactivities of Aeschynomene aspera (Fabaceae) Leaf Extract

Bioactivities of Aeschynomene aspera (Fabaceae) Leaf Extract

The First Case Series Report of Typhonium trilobatum Tuber Poisoning in Humans

Typhonium trilobatum Demonstrates Both Antioxidant and Acetylcholinesterase Inhibitory Activities In vitro

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