Antidiabetic Effect of Thymoquinone via Modulation of PPAR-γ, GLUT4, Hyperlipidemia and Antioxidant Status in Diabetic Rats

Abdel-Moneim, Adel; Abdel-Rehe, Eman Salah; Helmy, Hamdi; Addaleel, Wessam

doi:10.3923/ajbs.2018.203.209

Cited by 4 publications

(2 citation statements)

References 35 publications

(33 reference statements)

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“…It can result in better antihyperglycemic effect in type-2 diabetic rats than the non-capsulated compound ( Rani et al, 2018 ). In another research, intraperitoneal administration of thymoquinone (8) (50 mg/kg) resulted in amelioration of dyslipidemia, hypoinsulinemia, hyperglycemia, impaired antioxidant defense system and upregulation of the expression of PPAR-γ and GLUT4 genes in diabetic rats ( Moneim et al, 2018 ).…”

Section: Biological Activities: Preclinical In Vitro/in Vivo Studies Of the Genus Nigella And Activmentioning

confidence: 99%

Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

et al. 2021

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Nigella is a small genus of the family Ranunculaceae, which includes some popular species due to their culinary and medicinal properties, especially in Eastern Europe, Middle East, Western, and Central Asia. Therefore, this review covers the traditional uses and phytochemical composition of Nigella and, in particular, Nigella sativa. The pharmacological studies reported in vitro, in vivo, and in humans have also been reviewed. One of the main strength of the use of Nigella is that the seeds are rich in the omega-6 fatty acid linoleic acid and provide an extra-source of dietary phytochemicals, including the bioactive thymoquinone, and characteristics saponins, alkaloids, and flavonoids. Among Nigella species, N. sativa L. is the most studied plant from the genus. Due to the phytochemical composition and pharmacological properties, the seed and seed oil from this plant can be considered as good candidates to formulate functional ingredients on the basis of folklore and scientific knowledge. Nonetheless, the main limations are that more studies, especially, clinical trials are required to standardize the results, e.g. to establish active molecules, dosage, chemical profile, long-term effects and impact of cooking/incorporation into foods.

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Section: Biological Activities: Preclinical In Vitro/in Vivo Studies Of the Genus Nigella And Activmentioning

confidence: 99%

Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

et al. 2021

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“…Among them, one can cite antidiabetic, antioxidant, hypolipidemic, anti-inflammatory, and anticancer activities [ 147 ]. Thymoquinone modulates PPAR-γ and GLUT4 expression and inhibits the glycogen phosphorylase enzyme involved in glycogenolysis [ 148 , 149 ]. It has been reported to decrease blood glucose levels and oxidative stress in a rat model [ 150 ], decrease fasting insulin levels, improve glucose tolerance and insulin sensitivity, and reduce hepatic glucose production [ 151 ].…”

Section: Herbal-based Antidiabetic Medicines and Overview Of The Anti...mentioning

confidence: 99%

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

et al. 2022

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Diabetes is a metabolic pathology with chronic high blood glucose levels that occurs when the pancreas does not produce enough insulin or the body does not properly use the insulin it produces. Diabetes management is a puzzle and focuses on a healthy lifestyle, physical exercise, and medication. Thus far, the condition remains incurable; management just helps to control it. Its medical treatment is expensive and is to be followed for the long term, which is why people, especially from low-income countries, resort to herbal medicines. However, many active compounds isolated from plants (phytocompounds) are poorly bioavailable due to their low solubility, low permeability, or rapid elimination. To overcome these impediments and to alleviate the cost burden on disadvantaged populations, plant nanomedicines are being studied. Nanoparticulate formulations containing antidiabetic plant extracts or phytocompounds have shown promising results. We herein aimed to provide an overview of the use of lipid- and inorganic-based nanoparticulate delivery systems with plant extracts or phytocompounds for the treatment of diabetes while highlighting their advantages and limitations for clinical application. The findings from the reviewed works showed that these nanoparticulate formulations resulted in high antidiabetic activity at low doses compared to the corresponding plant extracts or phytocompounds alone. Moreover, it was shown that nanoparticulate systems address the poor bioavailability of herbal medicines, but the lack of enough preclinical and clinical pharmacokinetic and/or pharmacodynamic trials still delays their use in diabetic patients.

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The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet

Leisegang

Almaghrawi

Henkel

2021

Biomedicine & Pharmacotherapy

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Antidiabetic Effect of Thymoquinone via Modulation of PPAR-γ, GLUT4, Hyperlipidemia and Antioxidant Status in Diabetic Rats

Cited by 4 publications

References 35 publications

Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet

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