The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet

Leisegang, Kristian; Almaghrawi, Walid; Henkel, Ralf

doi:10.1016/j.biopha.2020.111085

Cited by 23 publications

(18 citation statements)

References 44 publications

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“…Supplementation with N. sativa oil in the vitrified semen of goats showed that N. sativa could preserve the quality of sperm parameters and the sperm membrane [ 32 ]. N. sativa oil has been reported to improve sperm parameters, testosterone level, and MMP in rats exposed to an obesogenic diet [ 33 ]. A study conducted in 2018 showed that aqueous NSE in cryopreserved buffalo spermatozoa improved sperm parameters, DNA integrity, and plasma membrane integrity due to its antioxidant activity, and these results are similar to those of this study [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of aqueous Nigella sativa extract on the functional parameters of post-thaw human spermatozoa during vitrification

Nasiri

Ghorbani

Seify

et al. 2022

Clin Exp Reprod Med

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Objective: Sperm vitrification leads to the production of reactive oxygen species (ROS) that can damage the functional parameters of sperm. The present study aimed to investigate the antioxidant effect of Nigella sativa extract on motility, plasma membrane function, mitochondrial membrane potential (MMP), DNA damage, and intracellular ROS production. Methods: A total of 20 sperm samples were used. Samples were divided into six experimental groups, including groups with aqueous extract from N. sativa seeds at concentrations of 1% to 6%, a cryopreserved control group, and a fresh control group. Results: Statistical analysis showed significantly higher total sperm motility at concentrations of 3% to 6% than in the vitrified semen control group. Additionally, progressive motility and all motion characteristics at all concentrations were significantly higher than in the vitrified semen control group. The presence of N. sativa seed extract also improved the quality of the sperm parameters assayed in all experimental groups (1%–6%; intracellular ROS production, DNA damage, MMP, and sperm membrane function) compared to the control group. Conclusion: Higher concentrations of N. sativa led to improvements in all sperm parameters and sperm quality. These findings indicate that N. sativa seed extract is effective for improving the quality of sperm after vitrification.

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Section: Discussionmentioning

confidence: 99%

Effect of aqueous Nigella sativa extract on the functional parameters of post-thaw human spermatozoa during vitrification

Nasiri

Ghorbani

Seify

et al. 2022

Clin Exp Reprod Med

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“…Wannasiri et al (36) and Vigueras-Villaseñor et al (37) induced hyperlipidemia in male Wistar or Sprague-Dawley rats by feeding with a highfat diet, found that the testosterone level was decreased in the high-fat diet group. It is proposed that elevated estradiol levels derived from peripheral aromatization of androgen inhibits the hypothalamic-pituitary-gonadal axis, resulting in a reduction of testosterone level (38,39). Our research indicated that the testosterone level and sperm count of epididymal tail were decreased in the MC group as well, which was probably due to hyperlipidemia.…”

Section: Discussionmentioning

confidence: 52%

Combining effect of camellia oil and squalene on hyperlipidemia-induced reproductive damage in male rats

Luo²,

Cheng³

et al. 2022

Front. Nutr.

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IntroductionCamellia oil (CO), a common edible oil in China, contains a variety of active ingredients. In this study, we explored the combining effect and optimal feeding time of CO and squalene on hyperlipemia-induced reproductive damage rats and probably provided supportive data for use of CO for health benefits.MethodsWe established the hyperlipidaemia-induced reproductive damage model, and then the successfully modeled rats were randomly classified into four groups including a model control (MC) group, a camellia oil (CO) group, a camellia oil + squalene (COS) group, and a sildenafil (SN) group, which were feeding with different subjects during days 30 and 60. The normal (NC) group was fed under the same conditions.ResultsOur results showed that compared with the MC group, the CO, COS, and SN groups could significantly decline the serum TG, TC and LDL-C levels, increase the serum testosterone levels, the sperm counts in epididymidis and organ coefficients of penises, and no pathological change in penis and testis at days 30 and 60. Compared with the pure CO, the mixture of CO and squalene could significantly enhance the effect of decreasing the concentrations of TG, TC, and LDL-C and increasing the serum testosterone level and sperm count of epididymal tail, and the results of day 30 were better than those of day 60.DiscussionCO and squalene have a combining effect on lowering blood lipid, improving the level of testosterone and the number of epididymal tail sperm, and promoting the recovery of erectile and sexual function on hyperlipidemia-induced reproductive damage rats on day 30.

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“…The production and release of breast milk occur after the baby is born, followed by a decrease in levels of the estrogen hormone, which increases prolactin levels for breast milk production (Leisegang et al, 2021). Even on the first day, although there is only a tiny amount of breast milk coming out; the mother must continue breastfeeding.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

Zakaria

Astuti

2022

j. info kesehat.

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Breast milk is the best nutrient to reduce the pain in nursing mothers and death in infants. However, for nursing mothers, too little milk volume is the cause of problems occurring during the breastfeeding process. Thus, mothers who breastfeed should consume foods that can increase the breast milk volume. One food frequently consumed by mothers to increase breast milk is honey. In fact, natural honey is challenging to discover, and the price is also high which makes it as an obstacle. A more economical alternative is required, one of which is black cumin. It is easy to obtain and the price is also affordable. Black cumin also contains galactagogue to increase prolactin that influences breast milk production. The objective of this study is to identify the effect of black cumin on the volume of breast milk. The study was a randomized controlled trial involving 60 breastfeeding mothers divided into intervention groups and control groups. The intervention group was provided 15 grams of black cumin brewed with 1000C boiling water as much as 200 ml, and the control group was assigned 15 grams of pure honey brewed boiling 1000C as much as 200 ml. Intervention and control were administered on the second day to the day of completion after giving birth. They were measuring instruments which accustomed to measure breast milk pumps. Bivariate analysis employing the Wilcoxon and Mann Whitney tests presented a significant difference between the volume of breast milk (p = 0.001) of the control and intervention groups. This study recommends the application of black cumin as a strategy to increase the volume of breast milk in nursing mothers.

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The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet

Cited by 23 publications

References 44 publications

Effect of aqueous Nigella sativa extract on the functional parameters of post-thaw human spermatozoa during vitrification

Effect of aqueous Nigella sativa extract on the functional parameters of post-thaw human spermatozoa during vitrification

Combining effect of camellia oil and squalene on hyperlipidemia-induced reproductive damage in male rats

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

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