Antidiabetic effect of <i>Ceiba pentandra</i> extract on streptozo-tocin-induced non-insulin-dependent diabetic (niddm) rats

Abstract

The aim of this work was to investigate the effect of daily oral administration of root bark methylene chloride/methanol extract of Ceiba pentandra (Linn) in streptozotocin-induced type-2 diabetic rats, and the effect of this treatment on the physiological and metabolic parameters that are related in diabetic animals. The diabetic rats were separated into four groups and each given the following samples by gavage, daily for 28 days: vehicle (diabetic control), Ceiba pentandra extract at the dose of 40 mg/kg, Ceiba pentandra extract at the dose of 75 mg/kg and glibenclamide (5 mg/kg). All the parameters were also determined in healthy (non diabetic) rats for comparison. The methylene chloride/methanol extract of Ceiba pentandra treatment significantly reduced the intake of both food and water as well as the levels of blood glucose, serum cholesterol, triglyceride, creatinine and urea, in comparison with diabetic controls. The treatment also improves impaired glucose tolerance but no effect was observed in the level of hepatic glycogen. The effect of Ceiba pentandra (40 mg/kg) was more prominent when compared to glibenclamide in lowering blood glucose, with the added benefit of considerably reducing serum cholesterol and triglyceride concentrations. The results of this experimental animal study indicated that Ceiba pentandra possesses antidiabetic activity; and thus is capable of ameliorating hyperglycaemia in streptozotocin-induced type-2 diabetic rats and is a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model

“…Moreover, the extract prevented the increase in the serum glucose level induced by chronic ethanol and sucrose feeding suggesting its hypoglycaemic activity. The improvement of blood glucose level induced by the aqueous extract was associated with a reduction of serum triglycerides and total cholesterol as previously mentioned for most hypoglycaemic treatments [ 37 ]. The glucose lowering effect of the extract may be due to its ability to improve the function of pancreatic β cells by increasing cells sensitivity to insulin and/or the rate of glucose transport and utilization [ 14 ].…”

Comparative Hypoglycemic Property of Aqueous and Ethanolic Extracts of Viscum album (Mistletoe) and Their Effects on Body and Organ Weights of Diabetic Rats (Rattus norvegicus).

“…Likewise, the improvements in pancreas weights of diabetic rats subsequent to administration of the leaf extracts suggested extra-pancreatic mechanisms of action of V. album as previously posited elsewhere. [11,54,55] It is worthwhile to note that within the ambit of alterations in visceral organ weight as a basis for toxicologic assessment of V. album leaf extracts, indicators showed that administration of the leaf extracts at the present dose and form did not affect the heart and kidneys of the experimental rats. Furthermore, although both aqueous and ethanolic leaf extracts of V. album exhibited glycemic control in the experimental rats, the extracts did not possess the capacity to restore full therapeutic benefits within the limits of experimental time.…”

A Review on Role of Plant(s) Extracts and its Phytochemicals for the Management of Diabetes

“…Reduction of serum glucose [505] Stem bark extract Reduction in the blood glucose levels [505] Zygophyllaceae Peganum harmala Linn.…”