Comparative Hypoglycemic Property of Aqueous and Ethanolic Extracts of Viscum album (Mistletoe) and Their Effects on Body and Organ Weights of Diabetic Rats (Rattus norvegicus).

Chikezie, Paul Chidoka; Iheanacho, Kme

doi:10.5530/pc.2014.2.4

Cited by 4 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the increase in the relative weight of liver from the diabetic group may well denote liver disarrangement in the form of fatty infiltration with attendant enlargement of the liver and tissue hyperplasia as result of absence of glycemic control [51,52]. The reduction of the relative weight of the pancreas observed in diabetic group could be associated with the severity of the destruction of Langerhans islets by the alloxan [53]. Our result is in line with the decrease of the relative weight of pancreas seen in several studies as consequence of hyperglycemia [23,54,55].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hamadjida¹,

Metechie²,

Tchiengang³

et al. 2023

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

Plants are known to possess relatively high efficacy in the treatment of several chronic diseases with fewer adverse effects. In the recent years, numerous medicinal plants have been reported to be effective in treating diabetes. Hence, the present study aims to evaluate the antidiabetic property of hydroalcoholic extract of Hibiscus sabdariffa (HS) calyces in diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (150 mg/kg, b.w), in male Wistar rats. Diabetic rats were administered daily oral doses of HS (100, 200 and 400 mg/kg body weight) and Glibenclamide (10 mg/kg) for 21 days. Then, blood glucose levels, oral glucose tolerance test and lipid profiles were determined. Treatment with HS resulted in a significant dose dependent reduction of blood glucose levels accompanied by a significant improvement in body weight. The extract also enhanced the glucose tolerance and significantly decreased cholesterol, triglycerides, and low-density lipoproteins levels while the high-density lipoproteins level significantly increased. From the results obtained, it can therefore be concluded that Hibiscus sabdariffa has an antidiabetic effect in alloxan-induced diabetic rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hamadjida¹,

Metechie²,

Tchiengang³

et al. 2023

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…In the current study, over 14 days, the diabetic group continuously decreased in body weight. A lack of insulin or irregularities in the catabolism of macronutrients like fat and protein could be to blame for the drop in body weight, which would result in signifcant tissue protein loss and muscle loss [86]. Hence, the weight gains after repeated dose administration of the hydromethanolic leaf extract and solvent fractions of Podocarpus gracilis in STZ-induced diabetic mice were observed in this study.…”

Section: Discussionmentioning

confidence: 63%

In Vivo Hypolipidemic, Hypoglycemic, Antihyperglycemic, and In Vitro Antioxidant Effects of Podocarpus gracilis Leaf Extract and Fractions in Diabetic Mice

Jifar,

BaHammam,

Bayane

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Podocarpus gracilis is an evergreen, dioecious tree found in Ethiopia and other African nations. It can reach a height of 60 meters. Without any scientific validation, ethnobotanical studies conducted in Ethiopia revealed that the Podocarpus gracilis plant’s leaf is consumed orally to treat diabetes mellitus. Hence, this study aims to evaluate the in vivo blood glucose level lowering, lipid-lowering, and in vitro-free radical scavenging responses of Podocarpus gracilis leaf extract and fractions on experimental mice induced with diabetes. Methods. The in vitro antioxidant activity of PGC (Podocarpus gracilis) leaf extract was assessed by using a diphenyl-2-picrylhydrazyl (DPPH) assay. The oral glucose-loaded, normoglycemic, and streptozotocin- (STZ-) induced diabetic mouse models were employed. In the STZ-induced mice model, the leaf extract and solvent fractions activity on serum lipid and weight were also measured. The extract and fractions were tested at 100, 200, and 400 mg/kg dosages. One-way ANOVA was used to determine the statistical significance of BGL (blood glucose level) changes within and between groups, and Tukey’s post hoc multiple comparisons were then performed. Results. In the acute toxicity study of Podocarpus gracilis leaf extract and fractions, there was no evidence of animal mortality at the maximum dose of 2 g/kg during the observation period. The extract-treated group with normoglycemia revealed a significant lowering in BGL at the 4-hour mark of 27.4% ( p < 0.001 ) and 25.2% ( p < 0.01 ) at doses of 200 mg/kg and 400 mg/kg, respectively, compared to that in negative control. In the oral glucose tolerance test (OGTT) model, only 400 mg/kg treated groups at 120 min after exposure showed a BGL reduction of 31.17% which was statistically significant ( p < 0.05 ) in comparison to the negative control. In the single-dose STZ-induced model, eighth-hour BGL measurements from CE 100, CE 200, CE 400, and GLC5 showed drops in BGL of 43.1%, 44.1%, 45%, and 47.3% from baseline fasting BGL values. In the repeated streptozotocin (STZ)-induced model, at all doses of leaf extract and fractions, the fasting BGL was significantly ( p < 0.001 ) reduced. Moreover, the leaf extract and solvent fractions have shown a significant ( p < 0.001 ) reduction of serum lipids such as LDL, TC, and VLDL, and at the same time, it increases HDL at 14 days with body weight gained. In the test for antioxidant activity, the half-maximal inhibitory concentrations (IC50) for leaf extract and the standard medication (ascorbic acid) were 8.2 μg/ml and 3.3 μg/ml, respectively. The IC50 value denotes the concentration of the sample required to scavenge 50% DPPH radicals. Conclusion. The 80% hydromethanolic leaf extract and fractions of Podocarpus gracilis exhibited blood glucose lowering, lipid-lowering activity in normoglycemic, oral glucose tolerance test (OGTT) mode, and STZ-induced diabetic mice with weight gains. There is scientific support for the alleged traditional use as an antidiabetic, lipid-lowering, and antioxidant activity. The results need to be confirmed by future studies.

show abstract

“…Centuries before the development of conventional medicine, medicinal herbs were utilized [27]. Plants have long been recognized as authentic sources of a wide range of bioactive compounds with significant therapeutic and medical potential [4]. The control of diabetes mellitus is greatly influenced by diet.…”

Section: Introductionmentioning

confidence: 99%

Effect of combined seeds of Sesemum indicum and Moringa oleifera compounded feed on liver function markers of alloxan-induced diabetic albino rats

GERALDINE OBUMNEME UDEBUNU,

KIZITO MUNACHISO IHEANACHO,

FAVOUR NTITE UJOWUDU

et al. 2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

This study investigated the effect of combined seeds of Sesemum indicum (SI) and Moringa oleifera (MO) on liver function markers in alloxan-induced diabetic albino rats. 54 albino rats were divided into 9 groups of 6 animals each. Group 1 served as the normal control and received standard feed diet, Group 2 (Diabetic control) received intraperitoneal injection of 140mg/kg of Alloxan, Group 3 (Positive control) received 5mg/kg of glibenclamide, Group 4; diabetic rats fed diet containing 15% of SI. Group 5; diabetic rat fed with 15% of MO diet, Group 6; diabetic rat fed with combination of 15% SI and 15% MO compounded diet. Group 7; diabetic rat fed with 30% of SI diet. Group 8; diabetic rat fed with 30% of MO diet. Group 9; diabetic rat fed with combination of 30% MO and 30% SI diet. The Feed was compounded and was given daily for 14 days. Serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein, albumin, and bilirubin were estimated to assess hepatic function using spectrophotometric method. Results showed a significant decrease in ALT, ALP, AST, and bilirubin levels when fed with compounded feeds at (p<0.05). Also feeding of diet with combined seeds significantly (P<0.05) increased the total protein and albumin in induced rats. Overall, compounded feed with combined seeds of SI and MO exhibited a promising anti-diabetic activity and normalized the liver enzyme activities which appeared comparable to the control glibenclamide in alloxan-induced diabetes hence, may be recommended for treatment/management of diabetes mellitus.

show abstract

Comparative Hypoglycemic Property of Aqueous and Ethanolic Extracts of Viscum album (Mistletoe) and Their Effects on Body and Organ Weights of Diabetic Rats (Rattus norvegicus).

Cited by 4 publications

References 40 publications

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

In Vivo Hypolipidemic, Hypoglycemic, Antihyperglycemic, and In Vitro Antioxidant Effects of Podocarpus gracilis Leaf Extract and Fractions in Diabetic Mice

Effect of combined seeds of Sesemum indicum and Moringa oleifera compounded feed on liver function markers of alloxan-induced diabetic albino rats

Contact Info

Product

Resources

About