Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocin-induced diabetes

Liu, Cheng-Tzu; Wong, Pei-Linn; Lii, Chong‐Kuei; Hse, Hunry; Sheen, Lee‐Yan

doi:10.1016/j.fct.2005.07.013

Cited by 93 publications

(64 citation statements)

References 47 publications

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“…This finding is made more interesting by the fact that many studies [17][18][19][20] have shown that allicin is hypoglycemic in both types of diabetes through biochemical evidence while in this study we have proved that allicin has a significant effect on the production of main autoimmune antibodies in IDDM that lead to affect and stop the disease autoimmune process of IDDM.…”

Section: Discussionsupporting

confidence: 48%

“…The animals were fed daily with rodent pellet diet and tap water ad libitum under strict hygienic conditions. Ethical clearance for performing the experiment on animals was approved by the Animal Care and Use Committee (ACUC), Faculty of Medicine, Universiti Teknologi MARA (UiTM) Malaysia that conforms to the Guide for the Care and Use of Laboratory Animals [20] and all efforts were made to minimize animal suffering and the number of animals used.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…Many studies have examined the hypoglycemic effect of allicin in both types of DM [17][18][19][20], but till now the mechanism has not been discussed with regard to IDDM while the probable mechanism underlying garlic and allicin hypoglycemic effects in type 2 diabetes most likely is increased insulin secretion and sensitivity [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

Osman

Adnan

Bakar

et al. 2012

pjp

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The research purpose was to experimentally investigate the effect of allicin administration on the levels of main type 1 diabetes (IDDM) autoantibodies which are antiislet cell antibodies (ICA) with an attempt to find a relation between this immunological effect and histological and/or biochemical findings. We have evaluated, with the help of ELISA kits, the levels of ICA and serum insulin in male Sprague-Dawley rats with Streptozotocin-induced IDDM in addition to pancreatic histological findings. The four groups (6 rats each) under study received or not different intraperitoneal doses of allicin for a period of 30 days. Daily intraperitoneal administration of allicin (either at as low dose of 8 mg/kg or high dose of 16 mg/kg) for up to 30 days to type 1 diabetic rats effectively reduces levels of anti-islet cell antibodies and in addition, reduced the level of insulin due to damaged Langerhans islet cell was significantly increased in the serum due to a repairing tissue process in pancreatic tissues. These experimental results suggest that allicin treatment has a therapeutic protective effect against autoimmune reactions occurring in IDDM. The data may provide new strategies for using allicin to be recommended as an excellent candidate in the clinical management, control, and prevention of IDDM.

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Section: Discussionsupporting

confidence: 48%

Section: Experimental Animalsmentioning

confidence: 99%

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Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

Osman

Adnan

Bakar

et al. 2012

pjp

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“…Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats in rats with streptozotocin-induced diabetes (Liu et al, 2006). Application of plant cell culture technologies have improved production of plant secondary metabolites contributing to medicinal value of the plant (SchmedaHirschmanna et al, 2004;Nasim et al, 2010).…”

Section: Research Articlementioning

confidence: 99%

Alliin obtained from leaf extract of garlic grown underin situconditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Nasim

Dhir

Kapoor

et al. 2011

Pharmaceutical Biology

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“…Without a doubt, garlic is one of the most intensively studied plant species, and there are hundreds of publications on its properties. Scientific research is interested not only in the antimicrobial activity of garlic [9,10], which has been known from ancient times, but also in its ability to reduce the risk of cardiovascular events, its ability to stimulate the functions of the immune system [11], and its anticancer [12], antioxidant [13], antidiabetic, hepatoprotective, and detoxification properties [14,15].…”

Section: Introductionmentioning

confidence: 99%

Analysis of 5-Methyltryptamine,L-Tryptophan, 5-Hydroxy-L-Tryptophan, and Melatonin in the Bulbs of Garlic by Thin-Layer Chromatographic Method Coupled with Densitometric Detection

Muszyńska

Maślanka

Sułkowska-Ziaja

et al. 2014

Journal of Planar Chromatography – Modern TLC

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SummaryThin-layer chromatography (TLC) methods coupled with densitometric detection were employed in analyses for the presence of nonhallucinogenic indole compounds in methanol extracts from the garlic (Allium sativum L.) bulbs originating from China, Georgia, Spain, Mexico, and Poland, and from granulated garlic in the form of seasoning (commercial product). Four indole compounds for which the garlic bulbs were analyzed, were detected: 5-methyltryptamine, L-tryptophan, 5-hydroxy-L-tryptophan, and melatonin, the amounts of which ranged from 4.2 to 199.6 mg kg −1 dry weight. In contrast, only 3 indole compounds were found in the garlic bulbs from Spain: 5-methyltryptamine, L-tryptophan and melatonin (85.7, 120.1, and 9.6 mg kg −1 dry weight, respectively). The total amount of indole compounds in the extracts from the garlic bulbs from China was the highest (415.4 mg kg −1 dry weight), while the amounts in the others (from Georgia, Spain, Mexico, Poland) were similar and ranged from 215.4 to 283 mg kg −1 dry weight. The granular, freeze-dried garlic contained the lowest content of indole compounds, and their total amount was only 207 mg kg −1 dry weight.

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Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocin-induced diabetes

Cited by 93 publications

References 47 publications

Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

Alliin obtained from leaf extract of garlic grown underin situconditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Analysis of 5-Methyltryptamine,L-Tryptophan, 5-Hydroxy-L-Tryptophan, and Melatonin in the Bulbs of Garlic by Thin-Layer Chromatographic Method Coupled with Densitometric Detection

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