Antidiabetic coumarin and cyclitol compounds fromPeucedanum japonicum

Lee, Sung Ok; Choi, Sang Zin; Lee, Jong Hwa; Chung, Sung Hyun; Park, Sang Hyun; Kang, Hee Young; Yang, Eun Young; Cho, Hi Jae; Lee, Kang Ro

doi:10.1007/bf02975882

Cited by 56 publications

(33 citation statements)

References 7 publications

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“…These compounds were ident- ified as the following: kaempferol (1), kaempferol (Jung et al, 2003), kaempferol 7-O-β-D-glucopyranoside (3) (Geiger et al, 1978), (6) (Felser and Schimmer, 1999) (Bacon et al, 1975), quercetin 3-O-β-D-glucuronopyranoside (11) (Lu and Foo, 1999), isorhamnetin-3-O-β-D-glucopyranoside (12) (Hörhammer et al, 1966) (Markham et al, 1978), adenine (14) (Seyana et al, 1988), myo-inositol (15) (Lee et al, 2004;Breitmaier and Voelter, 1987), arbutin (16) (Hisatomi et al, 2000) and β-sitosterol glucopyranoside (17). Among these, compounds 3, 6, 7, 11, 14 -16 were identified for the first time in this plant.…”

Section: Resultsmentioning

confidence: 99%

Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens

Lim

Jung

Hyun

et al. 2006

Phytotherapy Research

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Aldose reductase, the principal enzyme of the polyol pathway, has been shown to play an important role in the complications associated with diabetes. A methanol extract of the stamens of Nelumbo nucifera Gaertn. was shown to exert an inhibitory effect on rat lens aldose reductase (RLAR), and thus was fractionated using several organic solvents, including dichloromethane, ethyl acetate and n-butanol. The ethyl acetate-soluble fraction, which manifested potent RLAR-inhibitory properties, was then purified further via repeated measures of silica gel and Sephadex LH-20 column chromatography. Thirteen flavonoids: kaempferol (1) and seven of its glycosides (2-9), myricetin 3',5'-dimethylether 3-O-beta-d-glucopyranoside (10), quercetin 3-O-beta-d-glucopyranoside (11) and two isorhamnetin glycosides (12, 13) were isolated from N. nucifera, as well as four non-flavonoid compounds: adenine (14), myo-inositol (15), arbutin (16) and beta-sitosterol glucopyranoside (17). These compounds were all assessed with regard to their RLAR-inhibitory properties. Among the isolated flavonoids, those harboring 3-O-alpha-l-rhamnopyranosyl-(1-->6)-beta-d-glucopyranoside groups in their C rings, including kaempferol 3-O-alpha-l-rhamnopyranosyl-(1-->6)-beta-d-glucopyranoside (5) and isorhamnetin 3-O-alpha-l-rhamnopyranosyl-(1-->6)-beta-d-glucopyranoside (13), were determined to exhibit the highest degree of rat lens aldose reductase inhibitory activity in vitro, evidencing IC(50) values (concentration required for a 50% inhibition of enzyme activity) of 5.6 and 9.0 microm, respectively.

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Section: Resultsmentioning

confidence: 99%

Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens

Lim

Jung

Hyun

et al. 2006

Phytotherapy Research

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“…Peucedanol 7-O-β-D-glucopyranoside (Lee et al, 2004), coumarin (1,2-benzopyrone) (Pari and Rajarajeswari, 2009), umbelliferone (Ramesh and Pugalendi, 2005), imperatorin, psoralen, 5-methoxypsoralen, 8-methoxypsoralen, iso-oxypeucedanin, pabulenol, oxypeucedanin methanolate, oxypeucedanin hydrate (Shalaby et al, 2014), iso-bergapten, pimpinellin, isopimpinellin, sphondin, scopoletin, phellopterin, byakangelicin and daucosterol (Zhang et al, 2017) were isolated from various plants belonging to the Apiaceae family and they were found to be antidiabetic. So, it may be a good approach in the treatment of type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots

Karakaya

Özbek

Gözcü

et al. 2018

Bangladesh J Pharmacol

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Eleven coumarins named osthole (1), imperatorin (2), bergapten (3), prantschimgin (4), grandivitinol (5), suberosin (6), xanthotoxin (7), felamidin (8), marmesin (9), umbelliferone (10), ulopterol (11), and a sterol mixture consisted of stigmasterol (12), β-sitosterol (13) were isolated from the roots of Ferulago blancheana, F. pachyloba and F. trachycarpa through in vitro bioassay-guided fractionation processes. The extracts and bioactive compounds were evaluated for their α-amylase and α-glucosidase activities. Among the tested compounds, felamidin and suberosin showed significant α-glucosidase inhibitory activity with IC50 values of 0.4 and 0.9 mg/mL, respectively, when compared to the reference standard acarbose (IC50 = 4.9 mg/mL). Grandivitinol (IC50 = 20.0 mg/mL) had the lowest inhibitory effect. On the other hand, none of the tested extracts were found to be active on α-amylase inhibition. This is the first report on isolation, characterization of the bioactive compounds and evaluation the α-amylase and α-glucosidase inhibitory activities of these species.Video Clip of Methodology:8 min 26 sec: <a href="https://www.youtube.com/v/x0gakPjgXmc">Full Screen</a> <a href="https://www.youtube.com/watch?v=x0gakPjgXmc">Alternate</a>

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“…Coumarin is a flavonoids class compound and widely distributed in nature also. The synthetic and natural Coumarin is known to possess anti diabetic activity [14], anabolic and antioxidant properties [15], anti-Cancer [16], lipid lowering property [17], anti-coagulants [18] and anti-oxidant property [19].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Bio-Evaluation of Novel N-(4-(8-Methoxy-2-Oxo-2H-Chromen-3-Yl) Thiazol-2-Yl) Amide Derivatives

Shah

Patel²,

Rajani³

et al. 2016

ILCPA

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Abstract. In present work novel derivatives of substituted N-(4-(8-methoxy-2-oxo-2H-chromen-3-yl) thiazol-2-yl) amide have been synthesized. The solvent free reaction of 2-Hydroxy-3-methoxybenzaldehyde with Ethyl acetoacetate in presence of Piperidine catalyst produces 3-acetyl-8-methoxy-2H-chromen-2-one (C). Compound C was α-brominated using CuBr 2 and subsequently cyclized using Thiourea to produce 3-(2-aminothiazol-4-yl)-8-methoxy-2H-chromen-2-one as main scaffold (E). This scaffold E was finally reacted with different Acid chloride to isolate title compound derivatives. The chemical structures of synthesized compounds were confirmed by 1 H-NMR, FT-IR and Mass spectral/LCMS analysis. The synthesized compounds were screened for potential Antimicrobial, Antifungal and Antimalerial activity.

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Antidiabetic coumarin and cyclitol compounds fromPeucedanum japonicum

Cited by 56 publications

References 7 publications

Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens

Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens

α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots

Synthesis and Bio-Evaluation of Novel N-(4-(8-Methoxy-2-Oxo-2<i>H</i>-Chromen-3-Yl) Thiazol-2-Yl) Amide Derivatives

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