Antidiabetic, Antihyperlipidemic and Renal Protective Activities of Garcinia Indica Linn. Clusiaceae

Abstract

To investigate the antidiabetic, antihyperlipidemic and renal protective activities of the aqueous and ethanol extract of Garcinia indica fruit rinds against alloxan induced diabetes in rats. Wistar rats were made diabetic by a single dose of alloxan hydrate [130 mg/kg i.p.]. After the successful induction of experimental diabetes, rats were divided into five groups each comprising a minimum of six rats. The effects of extracts and glibenclamide on fasting blood glucose, plasma lipid levels and renal profile were examined for 21 days. Blood glucose levels and biochemical parameters such as serum cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, urea and creatinine levels of rats were measured using on weekly intervals i.e day 0, 7, 14 and 21 after daily administration of all extracts at dose of 500 mg/kg. Statistical analysis was performed using Dunnett’s test. p less than 0.01 was taken as the criterion of significance. Oral administration of both aqueous and ethanol extract for 21 days caused a significant [p less than 0.01] reduction in blood glucose levels, lipid profile except HDL; urea and creatinine in diabetic rats. Garcinia indica fruit rind possesses antihyperglycemic activity as well improves total lipid levels and renal profile. It can justify folklore uses of the plant in diabetes.

Antihyperglycemic activity of fruit extracts of Sri Lankan endemic species <i>Garcinia quaesita</i> Pierre “Rathgoraka” and its isolated compound, garcinol

“…The oral administration of the aqueous extract of fruits of G. indica showed a significant reduction in blood glucose concentration between 30 to 120 minutes in both streptozotocin induced diabetic rats (p<0.001). Moreover, reports by Yamaguchi et al, (2000), Shetty and Pushpa (2018) and Deore et al, (2018) revealed that the fruit extract of G. indica significantly lowered the fasting blood glucose concentration in hyperglycemic rats in a long term study. Further, long term antihyperglycemic effects were reported based on Garcinia species such as G. cambogia, G. mangostana in diabetic animal models (Watanabe et al, 2018).…”

All‐trans retinoic acid improves pancreatic cell proliferation on induced type 1 diabetic rats

“…Weight and glucose were assessed after alloxan induction on day 2, 5, 10, and 16 according to previous procedure . Capillary blood samples were obtained after a 2 h fasting and measured with an Accu‐Check® glucose meter.…”

“…Hence, over the past decades, oxidative stress has been regarded as a major risk factor in the onset and progression of the disease . Cytotoxic activity of diabetogenic compounds, such as alloxan, is directed mainly toward promoting ROS release , alloxan is metabolized to dialuric acid, establishing a redox cycle where superoxide radicals are further produced . These free radicals can form hydrogen peroxide through dismutation, leading to the production of highly reactive hydroxyl radicals and a simultaneous surge of intracellular calcium, overall triggering rapid β‐cell apoptosis .…”

Structural analysis and antioxidant activity of an arabinoxylan from Malvastrum coromandelianum L. (Garcke)

“…31 Pharmacological screening of the aqueous extract exhibited signicant antidiabetic and antihyperlipidemic activities. 32,33 The extract also inhibited inammation induced by carrageenan and pain due to formalin stimulation. 34 A crude water extract from the aerial parts exhibited antibacterial activity against methicillin-resistant strains of Staphylococcus aureus.…”