Structural analysis and antioxidant activity of an arabinoxylan from <i>Malvastrum coromandelianum</i> L. (Garcke)

Devi, Shanti; Lakhera, Ajeet Kumar; Kumar, Vineet

doi:10.1039/c9ra01629e

Cited by 10 publications

(4 citation statements)

References 69 publications

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“…Finally, the OSB4 HA was associated with anomeric type C and TEAC (i.e., antioxidant activity). Oligosaccharides, which contain anomeric C, possess significant antioxidant activities ( Hou et al, 2015 ; Wang et al, 2016 ; Devi et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

“…The PC1/PC3 biplot also demonstrates the close association of OSB2 and OSB4 HAs with carbohydratic type C (i.e., anomeric and O-alkyl) and with EDC and TEAC, which demonstrated strong antioxidant activity for these HAs. Carbohydrates have been shown to possess significant antioxidant potential ( Hou et al, 2015 ; Wang et al, 2016 ; Devi et al, 2019 ). The OSB4 HA stimulated overall corn seedling growth to the second greatest extent, slightly less than OSB3 HA ( Table 5 ).…”

Section: Resultsmentioning

confidence: 99%

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RETRACTED: Use of Ore-Derived Humic Acids With Diverse Chemistries to Elucidate Structure-Activity Relationships (SAR) of Humic Acids in Plant Phenotypic Expression

Lamar¹,

Monda²,

Sleighter³

2021

Front. Plant Sci.

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We report the results of a structure-activity relationship study that was undertaken to identify humic substance chemistries that drive the plant biostimulant response. The effects of seven extensively chemically characterized, ore-derived humic acids (HA) on corn seedling biomass and root and shoot morphological parameters were investigated. Chemometric analyses were then conducted to identify correlations between HA chemical features and plant biomass and morphological characteristics. The primary chemical driver of plant biomass and morphology was the ratio between HA electron accepting capacity (EAC) and electron donating capacity (EDC). The HA electron accepting capacity is found in quinones and semiquinone free radicals, while the HA electron donating capacity is found in polyphenolics and glycosylated polyphenolics. Based on our results, we propose a mechanism of action for ore-derived HA plant biostimulation that involves the interplay of pro-oxidants, in the form of quinones and semiquinone radicals, and antioxidants, in the form of polyphenols and possibly glycones and carbohydrates. The quinones/semiquinones initiate an oxidative stress response via the stimulation of transmembrane electron flow that results in both reactive oxygen species (ROS) production (i.e., an oxidative burst) and membrane depolarization, the latter of which allows Ca2+ flux from the apoplast into the cytoplasm. Based on the magnitude of depolarization, a specific cytoplasmic Ca2+ signature is produced. As a secondary messenger Ca2+, via binding to Ca2+− sensor proteins, transmits the signature signal, resulting in specific intracellular responses that include changes to plant morphology. The greater the EAC, the greater the ROS production and magnitude of plasma membrane depolarization and resulting stress response. The HA antioxidants are able to scavenge and quench the ROS and thus modulate the intensity and extent of the stress response to greater or lesser degrees, based on their concentrations and radical scavenging efficiencies, and thus modify the Ca2+ signature and ultimately the intracellular molecular responses.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

RETRACTED: Use of Ore-Derived Humic Acids With Diverse Chemistries to Elucidate Structure-Activity Relationships (SAR) of Humic Acids in Plant Phenotypic Expression

Lamar¹,

Monda²,

Sleighter³

2021

Front. Plant Sci.

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“…The interest in these properties is consistent with the literature, which shows that various plant compounds possess helpful properties such as anti-oxidative, anti-inflammatory, and anticancer, among others [55]. MMPs such as Ximenia Americana, Manilkara zapota, and Curatella Americana have reported all the studied activities [56][57][58][59][60][61][62].…”

Section: Discussionsupporting

confidence: 75%

Selection of Mexican Medicinal Plants by Identification of Potential Phytochemicals with Anti-Aging, Anti-Inflammatory, and Anti-Oxidant Properties through Network Analysis and Chemoinformatic Screening

Barrera-Vázquez,

Montenegro-Herrera,

Martínez-Enríquez

et al. 2023

Biomolecules

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Many natural products have been acquired from plants for their helpful properties. Medicinal plants are used for treating a variety of pathologies or symptoms. The axes of many pathological processes are inflammation, oxidative stress, and senescence. This work is focused on identifying Mexican medicinal plants with potential anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects through network analysis and chemoinformatic screening of their phytochemicals. We used computational methods to analyze drug-like phytochemicals in Mexican medicinal plants, multi-target compounds, and signaling pathways related to anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence mechanisms. A total of 1373 phytochemicals are found in 1025 Mexican medicinal plants, and 148 compounds showed no harmful functionalities. These compounds displayed comparable structures with reference molecules. Based on their capacity to interact with pharmacological targets, three clusters of Mexican medicinal plants have been established. Curatella americana, Ximenia americana, Malvastrum coromandelianum, and Manilkara zapota all have anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects. Plumeria rubra, Lonchocarpus yucatanensis, and Salvia polystachya contained phytochemicals with anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence reported activity. Lonchocarpus guatemalensis, Vallesia glabra, Erythrina oaxacana, and Erythrina sousae have drug-like phytochemicals with potential anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects. Between the drug-like phytochemicals, lonchocarpin, vallesine, and erysotrine exhibit potential anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects. For the first time, we conducted an initial virtual screening of selected Mexican medicinal plants, which was subsequently confirmed in vivo, evaluating the anti-inflammatory activity of Lonchocarpus guatemalensis Benth in mice.

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“…Conversely, there is evidence showing the beneficial effects of RFOs which undergo partial fermentation in the large intestine acting as a prebiotics and enhancing the growth of lactobacilli and other bifidobacterial ultimately contributing to improved gut health (Berrios et al, 2010;Siva & Thavarajah, 2018). Furthermore, RFOs are reported to quench reactive oxygen species (ROS) by a reduction of N-nitroso compounds which can be formed in the gut (Devi, Lakhera, & Kumar, 2019;Van Loo et al, 1999). RFOs may also interact with Tol-like receptors stimulating the innate immune system (Crittenden & Playne, 1996;Rochfort & Panozzo, 2007).…”

Section: Author Manuscriptmentioning

confidence: 99%

Frost‐affected lentil (Lens culinaris M.) compositional changes through extrusion: Potential application for the food industry

Portman

Dolgow²,

Maharjan

et al. 2020

Cereal Chem

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Structural analysis and antioxidant activity of an arabinoxylan from Malvastrum coromandelianum L. (Garcke)

Abstract: The structure of MAP was studied by degradative, derivatization and spectroscopic methods, and it was found to be an arabinoxylan comprising a backbone of →4)-β-d-linked Xylp(1→ with branching at O-2 by →3)-α-l-Araf(1→ and →3)-β-d-Xylp(1→ chains.

Cited by 10 publications

References 69 publications

RETRACTED: Use of Ore-Derived Humic Acids With Diverse Chemistries to Elucidate Structure-Activity Relationships (SAR) of Humic Acids in Plant Phenotypic Expression

RETRACTED: Use of Ore-Derived Humic Acids With Diverse Chemistries to Elucidate Structure-Activity Relationships (SAR) of Humic Acids in Plant Phenotypic Expression

Selection of Mexican Medicinal Plants by Identification of Potential Phytochemicals with Anti-Aging, Anti-Inflammatory, and Anti-Oxidant Properties through Network Analysis and Chemoinformatic Screening

Frost‐affected lentil (Lens culinaris M.) compositional changes through extrusion: Potential application for the food industry

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