Antidiabetic and antihyperlipidemic activity of leaves of Alstonia scholaris Linn. R.Br.,

Arulmozhi, S.; Mazumder, Papiya Mitra; Lohidasan, Sathiyanarayanan; Thakurdesai, Prasad

doi:10.1016/j.eujim.2009.12.001

Cited by 42 publications

(19 citation statements)

References 24 publications

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“…Stz induced diabetic rat [86] Antidiabetic Leaf powder of A. scholaris Powder of leaves of A. scholaris causes a significant decrease in blood glucose level in human volunteers with Non-insulin dependent diabetes mellitus [87] Antihypertension Decoction of bark In patients with essential hypertension [88] Antidiarrheal and spasmolytic activities Methanolic crude extract of A. scholaris Method used was castor oil induced diarrhea for in vivo antidiarrheal activity and rabbit jejunum in vitro model for spasmolytic activity [89] Antidiarrheal formulation Charcoal suspension (10%) was used to study the effect of kutajarishta on percent intestinal transit, while its effect on electrolyte, mainly potassium secretion, was studied using glibenclamide in castor oil induced diarrhea [90] Aqueous and the alcoholic bark extracts…”

Section: Leaves Extractmentioning

confidence: 99%

Alstonia scholaris: It′s Phytochemistry and pharmacology

Kaushik

Sharma

et al. 2011

Chron Young Sci

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Complementary therapies based on herbal medicines are the world's oldest form of medicine and recent reports suggest that such therapies still enjoy vast popularity, especially in developing countries where most of the population does not have easy access to modern medicine. Alstonia scholaris (L.) R.Br (Apocynaceae) is an evergreen tropical tree native to Indian sub-continent and South East Asia, having grayish rough bark and milky sap rich in poisonous alkaloid. It is reported to contain various iridoids, alkaloids, coumarins, flavonoids, leucoanthocyanins, reducing sugars, simple phenolics, steroids, saponins and tannins. It has been reported to possess antimicrobial, antiamoebic, antidiarrheal, antiplasmodial, hepatoprotective, immunomodulatory, anticancer, antiasthmatic, free radical scavenging, antioxidant, analgesic, anti-inflammatory, antiulcer, antifertility and wound healing activities. In other parts of the world, it is used as a source cure against bacterial infection, malarial fever, toothache, rheumatism, snakebite, dysentery, bowl disorder, etc. Reports on the pharmacological activities of many isolated constituents from A. scholaris (L.) R.Br are lacking, which warrants further pharmacological studies.

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Section: Leaves Extractmentioning

confidence: 99%

Alstonia scholaris: It′s Phytochemistry and pharmacology

Kaushik

Sharma

et al. 2011

Chron Young Sci

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“…Several in vitro and in vivo studies were undertaken by researchers to evaluate traditional and local antidiabetic claim of A. scholaris. Antidiabetic potential of A. scholaris was studied in terms of its α-glucosidase inhibitory and hypoglycemic effects [42,43]. To date, potent antidiabetic activity was reported to the leaves and stem bark of A. scholaris [43,44].…”

Section: Antidiabetic Potentialmentioning

confidence: 99%

“…Antidiabetic potential of A. scholaris was studied in terms of its α-glucosidase inhibitory and hypoglycemic effects [42,43]. To date, potent antidiabetic activity was reported to the leaves and stem bark of A. scholaris [43,44]. The powder of A. scholaris leaves exerts a consistent hypoglycemic effect in patients suffering from non-insulin-dependent diabetes mellitus.…”

Section: Antidiabetic Potentialmentioning

confidence: 99%

A Pharmacognostic and Pharmacological Review on Alstonia Scholaris

Kanase

Mane²

2018

Asian J Pharm Clin Res

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Alstonia scholaris, commonly known as devil's tree, is an important medicinal plant in the various folk and traditional systems of medicine in Asia, Australia, and Africa. The plant is used in Ayurvedic, Unani, and Siddha types of alternative medicinal systems. The decoction, mostly prepared from the bark, is used to treat a variety of diseases, of which the most important is malaria. In Ayurveda, it is used as a bitter and as an astringent herb for treating skin disorders, malarial fever, urticaria, chronic dysentery, diarrhea, and in snake bite. A. scholaris is also observed to possess antioxidant, immunomodulatory effects, and free radical scavenging, anti-inflammatory, antimutagenic, anticancer, analgesic, hepatoprotective, wound healing, antidiarrheal, and antiplasmodial activities. The current review summarizes the numerous ethnobotanical and traditional uses as well as the phytochemical and pharmacological report on A. scholaris.

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“…[5,6] Extracts of A. scholaris is reported to possess several pharmacological activities that include antiplasmodial activity, [7] antimutagenic effect, [8] immunostimulatory effect, [9] hepatoprotective activity, [10] antidiabetic and antihyperlipidemic activities. [11] The plant is reported to relieve inflammation and chronic rheumatic pains in folklore medicine. [5] In our previous study ethanolic extracts of A. scholaris leaves showed significant anti-inflammatory activity (data not shown here).…”

Section: Introductionmentioning

confidence: 99%

Chromatographic finger print analysis and lysosomal membrane stabilisation activity of active fraction of Alstonia scholaris leaf extract in arthritic rats

Goyal¹,

Sheth²,

Srivastava³

2014

Int J Green Pharm

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Object:The present study was aimed to assess the anti-arthritic activity of chloroform fraction of Alstonia scholaris leaf extract against Freund's complete adjuvant (FCA)-induced arthritis in rats. Materials and Methods: The anti-inflammatory activity of various fractions of ethanolic extract of Alstonia scholaris at concentration of 100 mg/kg was studied using the carrageenan-induced inflammatory models. The chloroform fraction shows significant anti-inflammatory activity. The chloroform fraction was further studied for anti-arthritic activity and HPTLC fingerprint analysis. For anti-arthritic activity, the active chloroform fraction was administered at the concentrations of 50 and 100 mg/kg body weight. The effect of chloroform fraction on liver ALP, ACP and LDH levels of lysosomal enzymes of FCA arthritic animals were studied. Indomethacin and prednisolone (10 mg/kg) was used as standard. HPTLC studies were carried out using CAMAG HPTLC system equipped with linomat IV applicator, TLC scanner; Reprostar 3 and WIN CATS-4 software were used. Results: The chloroform fraction at 100 mg/kg, showed maximum inhibition (34.16%) of inflammation induced by carrageenan. In FCA-induced arthritis, the chloroform fraction showed a highly significant reduction in paw volume (50 mg/kg-72.71%; 100 mg/kg-74.35%). The levels of lysosomal enzymes were significantly decreased in the chloroform fraction-treated groups. Conclusion: The possible mechanism of action of the chloroform fraction of Alstonia scholaris leaf extract may be through its stabilising action on lysosomal membranes. Future studies will provide new insights into the anti-arthritic activity of Alstonia scholaris and isolation of compound from it may eventually lead to development of a new class of anti-arthritic agent.

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Antidiabetic and antihyperlipidemic activity of leaves of Alstonia scholaris Linn. R.Br.,

Cited by 42 publications

References 24 publications

Alstonia scholaris: It′s Phytochemistry and pharmacology

Alstonia scholaris: It′s Phytochemistry and pharmacology

A Pharmacognostic and Pharmacological Review on Alstonia Scholaris

Chromatographic finger print analysis and lysosomal membrane stabilisation activity of active fraction of Alstonia scholaris leaf extract in arthritic rats

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