Antidiabetic Activity of Nanoparticles Containing Javanese Turmeric Rhizome Extract: The Strategy to Change Particle Size

Rahmat, Deni; Farida, Yunahara; Brylianto, Avilla Tan; Sumarny, Ros; Kumala, Shirly

doi:10.22159/jap.2020v12i4.36249

Cited by 4 publications

(6 citation statements)

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“…It may thus be a useful alternative medicine to treat different kinds of DM [21]. Nanoparticle encapsulation has been reported to increase the bioavailability of active compounds in plant extracts [22,23]. Therefore, nanoencapsulation can improve the pharmacological activity of active compounds in okra fruits.…”

Section: In Mean±sd From 5 Experimentsmentioning

confidence: 99%

Nanoemulsion of Okra Fruit Extract as Antidiabetic Treatment

et al. 2020

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Objective: Okra (Abelmoschus esculentus (L.) Moench) has potential antidiabetic activity. This study created a nanoemulsion of okra extract (NOE) and examined its activity on alloxan-induced diabetes mellitus in mice. Methods: Okra was macerated with 70% ethanol and dried in a rotary evaporator into the crude extract. The extract was encapsulated in a solution of glyceryl caprylate, propylene glycol, and glycerine to form a nanoemulsion. To determine the antihyperglycaemic effect of okra extract, 35 male mice (Mus musculus L.) were divided into seven groups: a non-diabetic normal control group and six diabetic mice groups (untreated negative control, glibenclamide-treated positive control, and four treatments with okra ethanol extract (OEE) at 200 and 400 mg/kg BW and NOE at 200 and 400 mg/kg BW). Results: The group treated with NOE at 400 mg/kg BW (NOE400) had the lowest average blood glucose level of 93.4 mg/dL among hyperglycaemic mice. The decrease in blood glucose levels in NOE400 (52.05%) was significantly different from those in the positive control (42.63%) and OEE treatments (39.32%). The nanoemulsion used in this study fulfills quality requirements, with a mean particle size of 134.7 nm, a polydispersity index of 0.512, and a zeta value of −26.72 mV. Conclusion: NOE reduced blood glucose levels in alloxan-induced hyperglycaemic mice better than OEE. Nanoemulsion can improve the antidiabetic activity of okra extract by increasing penetration of active compounds into interstitial space so that their delivery and bioavailability are higher.

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Section: In Mean±sd From 5 Experimentsmentioning

confidence: 99%

Nanoemulsion of Okra Fruit Extract as Antidiabetic Treatment

et al. 2020

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“…Nanoparticles were prepared based on the method used by [11] with slight modifications. Briefly, 0.4 gram of chitosan was dissolved in 100 ml of 1% glacial acetic acid using a magnetic stirrer to obtain a concentration of 0.4% chitosan.…”

Section: Nanoparticles Preparationmentioning

confidence: 99%

Characterization of Nanoparticles Conditioned Medium Adipose Tissue Mesenchymal Stem Cell (Cm-Atmsc)

et al. 2022

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Objective: The aims of this study were to formulate and characterize the nanoparticles containing conditioned medium adipose tissue mesenchymal stem cell (CM-ATMSC). Methods: Adipose Tissue Mesenchymal Stem Cell (AT-MSC) was cultured with supplemented Modified Eagle Medium (MEM) Alpha in an incubator with 37 °C and 5% CO2. The conditioned medium was collected when the cells were confluent. Nanoparticles were characterized in the term of morphology using transmission electron microscopy (TEM), particle size, zeta potential, loading capacity, entrapment efficiency, and drug release. Results: CM-ATMSC nanoparticles had the smallest particle size, namely chitosan-inulin nanoparticles with particle size of 128 nm, and the largest particle was modified chitosan (thiomer)-fucoidan nanoparticles with particle size of 254.3 nm. Based on zeta potential results, it is known that the resulting nanoparticle suspension was stable. Conclusion: The resulting nanoparticle suspension was stable and the smallest CM-ATMSC nanoparticle demonstrated the particle size of 128 nm. The results showed that the nanoparticles of CM-ATMSC have been successfully prepared.

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“…Afterwards, 40 ml of chitosan solution was added to each formula with different concentrations (1%, 1.5%, and 2% (w/v)). The final mixture was dried using a spray dryer with an inlet temperature of 180 °C and an outlet temperature of 80 °C [8,9].…”

Section: Preparation Of Microcapsulesmentioning

confidence: 99%

“…This could be caused by the addition of chitosan at the highest concentration. Therefore, only FIII and FVI were then spray dried and evaluated for their characteristics [8,9]. The results of organoleptic evaluation of microcapsules FIII and F4VI showed that the microcapsules produced were dark red in colour (fig.…”

Section: Microcapsules Organoleptic and Morphologymentioning

confidence: 99%

“…Moreover, the microcapsules can be further formulated into various solid dosage forms [5][6][7]. In previous studies, the use of chitosan as a matrix in nanocurcumin could increase the solubility of curcumin [8,9]. Therefore, in this study, the microencapsulation of curcumin was developed using the same formula as the nanocurcumin as reported in previous studies with slightly modification by adding ethyl cellulose and glyceryl monostearate (GMS).…”

Section: Introductionmentioning

confidence: 99%

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Curcumin Microencapsulation Using Chitosan–ethyl Cellulose–gms Mixture for Preservation of Mucoadhesive Properties and Controlled Release Kinetic

et al. 2022

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Objective: This research aimed to prepare curcumin microcapsules by the spray drying method and to evaluate their characteristics. Methods: The microcapsules were prepared by the spray drying method. The generated microcapsules were evaluated for organoleptic, morphology, particle size, the percentage of curcumin and water content. Furthermore, the release of curcumin from the microcapsules was tested in vitro and compared to uncoated curcumin powder. In addition, the mucoadhesive properties of uncoated curcumin powder and curcumin microcapsules were also evaluated. Results: The results showed that the microcapsules had spherical shape with particle size in the range of 100–1009 µm and water content of 9.34% (w/w) (FIII) and 8.09% (w/w) (FVI). The release of curcumin from its uncoated powder and the microcapsules FVI within 8 h were 8.87% and 26.32% (w/w), respectively. It was found that the mucoadhesive properties of microcapsules FVI were better than those of FIII and uncoated curcumin powder. Microcapsules FVI rendered the cumulative amount of curcumin remaining on the intestinal mucosa of 55% (w/w) within 3 h. Conclusion: Accordingly, curcumin microcapsules generated by spray drying could be further formulated into various solid dosage forms for a better therapeutic effect.

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Antidiabetic Activity of Nanoparticles Containing Javanese Turmeric Rhizome Extract: The Strategy to Change Particle Size

Cited by 4 publications

References 0 publications

Nanoemulsion of Okra Fruit Extract as Antidiabetic Treatment

Nanoemulsion of Okra Fruit Extract as Antidiabetic Treatment

Characterization of Nanoparticles Conditioned Medium Adipose Tissue Mesenchymal Stem Cell (Cm-Atmsc)

Curcumin Microencapsulation Using Chitosan–ethyl Cellulose–gms Mixture for Preservation of Mucoadhesive Properties and Controlled Release Kinetic

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