Antidiabetic activity of Caesalpinia bonducella F. in chronic type 2 diabetic model in Long-Evans rats and evaluation of insulin secretagogue property of its fractions on isolated islets

Pharmacokinetic and Pharmacodynamic Interaction of Curcumin with Glimepiride in Normal and Diabetic Rats

“…It reveals that these drugs do not have any effect on degradation of depot fat to maintain the body weight. [18] Combination of glimepiride with curcumin and curcumin alone pretreated groups reduced significantly (p < 0.01) the blood glucose levels after 7 days to till the end of the study (28 days). This phenomenon clearly indicates that these drugs in combination control the hyperglycemic state of type 2 diabetes more effectively than alone treated drugs.…”

Enhanced Bioavailability of Glimepiride in the Presence of Boswellic Acids in Streptozotocin-Induced Diabetic Rat Model

“…This significant improvement in body weight indicates the ability of combination of drugs and individual drugs to prevent loss of body weight in diabetic rats. It reveals that these drugs do not have any effect on degradation of depot fat to maintain the body weight [21].…”

Emerging Challenge of Type 2 Diabetes: Prospects of Medicinal Plants

“…If found to have some degree of toxicity, the risks can be weighed against the benefits and decisions can be made regarding their continued availability. The plant materials which have been mentioned here, a few of them were studied with a longer durationin in streptozotocin induced diabetic model rats (Chakrabarti et al 2005;Bandara et al 2010) and also inType 2 diabetic subjects (Bandara et al 2019). After chronic oral feeding their serum alanine amino transferase (ALT) and serum creatinine levels have been determined as a marker of liver and kidney toxicities.…”