Enhanced Bioavailability of Glimepiride in the Presence of Boswellic Acids in Streptozotocin-Induced Diabetic Rat Model

Samala, Sujatha

doi:10.4172/2329-6836.1000116

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…Figure 3 portrays the IR spectrum of emodin obtained at the M062x/6-31g (d, p) level of theory, 1 HNMR and 13 CNMR Spectra interpretation for methanol extract. 1 H NMR of the sample (Table 3) contains; 4 sets of aromatic peaks (7.53, 7.23, 7.12 and 6.62), two sets of phenolic peaks (12.12 and 12.06 ) and one set of methyl groups (2.38, attached to aromatic ring) protons. 13 C NMR chemical shift values (Table 4) revealed the presence of; 12 aromatic peaks (166.2, 164.9, 161.8, 148.7, 135.7, 133.4, 124.6, 121.0, 113.9, 109.5, 108.5 and 108.4), 2 carbonyls C (NMR) of the spectra were recorded on NMR machine: JEOL-LA-400 MHz FT-NMR spectrophotometer, at SIPBS, University, Strathclyde, Glasgow, United Kingdom, using deuterated solvents as indicated by Tables 3 and 4.…”

Section: Ftir Spectra Data For Isolated Emodinmentioning

confidence: 99%

“…The phenomenon of screening plants for the presence of phyto-molecules of medicinal importance is common place. Natural products have pharmaceutical / pharmacological activity that are useful in treating diseases and are the starting points for drugs discovery from which synthetic drug analogues can be prepared with improved efficacy, potency, safety and purity [1], when isolated, synthetic strategies and tactics are used by organic Chemists providing challenging mechanisms that permit the biologically active product to the target site. A review reported that 577 plant species have been used traditionally due to the secondary metabolites in them, [2 & 3].…”

Section: Introductionmentioning

confidence: 99%

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Computational studies on Emodin (C15H10O5) from Methanol extract of Pteridium acquilinum leaves

Khan¹,

Etim²,

Anyam³

et al. 2021

J. Nig. Soc. Phys. Sci.

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This research isolates, characterizes, and studies the computational and frequency calculations of emodin, extracted from the leaf extract of Pteridium acquilinum leaves using methanol. Vacuum liquid and tin layer Chromatography was used for the purification of the molecule. The (VLC purified), fraction was analyzed by Nuclear magnetic resonance (NMR) and the chemical structure of the compound isolated (anthraquinone), was confirmed by 1H & 13C-NMR analyses as emodin (C15H10O5). Computational and frequency studies have been done on the isolated molecule. Optimized geometry, IR frequencies, Bond distances (R) and angles (A), Dipole moments and other parameters have been computationally determined for the isolated molecule from quantum chemical calculations using the GAUSSIAN 09 retinue programs. Experimentally determined and computationally measured IR frequencies agree perfectly with each other. Computational studies can be used to predict unobserved chemical phenomena like design of new drugs and materials such as the positions of constituent atoms in relationship to their relative and absolute energies, electronic charge densities, dipoles, higher multiple moments, vibrational frequencies, relativity or other spectroscopic quantities and cross sections for collision with other molecules. This is the first time this anthraquinone, [emodin], with most of the parameters examined is reported from P. aquilinum.

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Section: Ftir Spectra Data For Isolated Emodinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Computational studies on Emodin (C15H10O5) from Methanol extract of Pteridium acquilinum leaves

Khan¹,

Etim²,

Anyam³

et al. 2021

J. Nig. Soc. Phys. Sci.

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“…In vitro studies, in vivo studies in animal Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2D6 CYP3A4 (Frank & Unger, 2006) Glimepiride (Samala & Veeresham, 2013) Andrographis paniculata (Kalmegh)…”

Section: Introductionmentioning

confidence: 99%

Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data

Thikekar

Thomas

Chitlange

2021

Phytotherapy Research

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Global diabetes epidemic is the major cause of fatality and lethality. As per IDF 2019 report, diabetes caused 4.2 million deaths, approximately 463 million people are living with diabetes and by 2045, this will rise to 700 million. Nowadays, the physicians and common people in both developed and developing countries are using medicinal plants and their formulations to treat diseases with the postulation that organic commodities are safe for consumption. These plants may act as inhibitors or inducers of the Cytochrome P450 or transport and efflux proteins or both and may alter gastrointestinal, renal functions leading to Herb‐Drug Interactions. This review intends to focus on the frequently employed medicinal plants, their traditional uses, their Cytochrome P450 inhibition or induction activity, phytochemical, and pharmacological effects, established HDI with the help of in vitro tools, in vivo pharmacokinetics and pharmacodynamics studies to understand the impact of herbs on ADME of the drug and whether it is beneficial, harmful or has no effect respectively. This review will help the physicians and other health care professionals as a reference guide to update their knowledge and expertise about HDI. However, more quality research in this area is needed to evaluate the efficacy of many herbal medicines, thereby reducing side effects and improving the safety of patients.

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“…HL-60 cells are mostly used as a cell model to evaluate pharmacological and physiological effects on myeloid differentiation and other aspects. Natural products are comprised of a huge number of chemicals that pose no threat to naturally balanced systems in humans and also act as potential pharmacological agents (11)(12)(13)(14)(15). Naturally occurring Kava plant comprises of different chemical entities including kavalactones.…”

mentioning

confidence: 99%

Anticancer effects of 7,8-dihydromethysticin in human leukemia cells are mediated via cell-cycle dysregulation, inhibition of cell migration and invasion and targeting JAK/STAT pathway

et al. 2021

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The main focus of this research work was to study the anti-cancer properties of 7,8-dihydromethysticin against HL-60 leukemia cells. Investigations were also performed to check its impact on the phases of the cell cycle, cell migration and invasion, JAK/STAT signalling pathway and intracellular mitochondrial membrane potential (MMP) and reactive oxygen species (ROS). Cell proliferation was assessed through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and effects on colony formation were examined via clonogenic assay. Flow cytometry and Western blott analysis were performed to investigate the distribution of cell cycle phases. Flow cytometric analysis was performed for the examination of MMP and ROS production. The effect on JAK/STAT signalling pathway was examined through Western blot analysis. Results depicted that 7,8-dihydromethysticin induced concentration- as well as time-dependent inhibition of cell proliferation in leukemia HL-60 cells. Clonogenic assay indicated potential suppression in leukemia HL-60 cell colonies. The 7,8-dihydromethysticin molecule also caused cell cycle arrest at G2/M-phase along with concentration-dependent inhibition of cyclin B1, D1 and E. ROS and MMP measurements indicated significant ROS enhancement and MMP suppression with increasing 7,8-dihydromethysticin concentrations. Additionally, 7,8-dihydromethysticin led to remarkable dose-reliant inhibition of cell invasion as well as cell migration. Therefore, 7,8-dihydromethysticin should be considered a valuable candidate for leukemia research and chemoprevention.

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Enhanced Bioavailability of Glimepiride in the Presence of Boswellic Acids in Streptozotocin-Induced Diabetic Rat Model

Cited by 6 publications

References 20 publications

Computational studies on Emodin (C15H10O5) from Methanol extract of Pteridium acquilinum leaves

Computational studies on Emodin (C15H10O5) from Methanol extract of Pteridium acquilinum leaves

Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data

Anticancer effects of 7,8-dihydromethysticin in human leukemia cells are mediated via cell-cycle dysregulation, inhibition of cell migration and invasion and targeting JAK/STAT pathway

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