Pharmacokinetic and Pharmacodynamic Interaction of Curcumin with Glimepiride in Normal and Diabetic Rats

Thatipamula, Sandya Rani; Samala, Sujatha; Veeresham, Ciddi

doi:10.5530/pc.2012.3.4

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Blood glucose level (BGL) was measured at different time intervals (0,1,2,3,4,5,6,8,12,18, and 24 h) up to 24 h. Each animal served as its own control and hence, the hypoglycemic response was evaluated as percentage decrease in blood glucose level. The pharmacodynamic parameter of the area under percentage decrease in BGL versus time curve (AUC 0-24h ) was calculated by adopting the trapezoidal rule (Wagner, 1975;Ammar et al, 2006;Sandya et al, 2012).…”

Section: Assessment Of Therapeutic Efficacy In Albino Rabbitsmentioning

confidence: 99%

Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits

Mohd¹,

Sanka²,

Bandi³

et al. 2014

Drug Delivery

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(2015) Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits, Drug Delivery, 22:4, 499-508, DOI: 10.3109/10717544.2013 Context: This study presents novel self-nanoemulsifying drug delivery system potential of oral delivering which leads poorly aqueous soluble drug glimepiride.Objective: The objective of this study was to prepare solid self-nanoemulsifying drug delivery system (S-SNEDDS) for the improved oral delivery of glimepiride and to evaluate its therapeutic efficacy in albino rabbits.Results and discussion: The droplet size analyses revealed a droplet size of less than 200 nm. The solid state characterization of S-SNEDDS by scanning electron microscopy (SEM), X-ray powder diffraction and differential scanning calorimetry (DSC) revealed the absence of crystalline glimepiride in the S-SNEDDS. The in vitro dissolution studies revealed that the significant improvement in glimepiride release characteristics. The effect of S-SNEDDS on therapeutic efficacy of glimepride was assessed in albino rabbits by monitoring blood glucose levels and compared with free drug suspension, L-SNEDDS. The S-SNEDDS showed significant (p50.05) increase in in vitro drug release and therapeutic efficacy as compared with free drug. Conclusion: This study demonstrated that S-SNEDDS is a promising novel drug delivery system of glimepride to enhance oral delivery.

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Section: Assessment Of Therapeutic Efficacy In Albino Rabbitsmentioning

confidence: 99%

Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits

Mohd¹,

Sanka²,

Bandi³

et al. 2014

Drug Delivery

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“…In addition, garlic extract in combination with another sulphonylurea, gliclazide, significantly decreased blood glucose level in STZ-induced diabetic rats [237]. Glimepiride (another member of the sulphonylurea group) with curcumin had protective effects against diabetic alterations associated with selected biochemical parameters and total antioxidant status in diabetic rats [238].…”

Section: Sulphonylureas With Natural Productsmentioning

confidence: 99%

Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus

et al. 2021

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Type 2 diabetes mellitus (T2DM) is the most widespread form of diabetes, characterized by chronic hyperglycaemia, insulin resistance, and inefficient insulin secretion and action. Primary care in T2DM is pharmacological, using drugs of several groups that include insulin sensitisers (e.g., biguanides, thiazolidinediones), insulin secretagogues (e.g., sulphonylureas, meglinides), alpha-glucosidase inhibitors, and the newest incretin-based therapies and sodium–glucose co-transporter 2 inhibitors. However, their long-term application can cause many harmful side effects, emphasising the importance of the using natural therapeutic products. Natural health substances including non-flavonoid polyphenols (e.g., resveratrol, curcumin, tannins, and lignans), flavonoids (e.g., anthocyanins, epigallocatechin gallate, quercetin, naringin, rutin, and kaempferol), plant fruits, vegetables and other products (e.g., garlic, green tea, blackcurrant, rowanberry, bilberry, strawberry, cornelian cherry, olive oil, sesame oil, and carrot) may be a safer alternative to primary pharmacological therapy. They are recommended as food supplements to prevent and/or ameliorate T2DM-related complications. In the advanced stage of T2DM, the combination therapy of synthetic agents and natural compounds with synergistic interactions makes the treatment more efficient. In this review, both pharmaceutical drugs and selected natural products, as well as combination therapies, are characterized. Mechanisms of their action and possible negative side effects are also provided.

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“…The combination of curcumin‐glimepiride in reduced the blood glucose levels after 28 days by 57.5% comparable to the glimepiride (51.2%) and curcumin (46.8%) group alone. The results revealed that combination of glimepiride with curcumin led to the enhancement of bioavailability of glimepiride by inhibiting the CYP2C9 enzyme, which suggested that curcumin might be beneficial as an adjuvant to glimepiride in a proper dose, in diabetic patients (Sandya Rani, Sujatha, & Veeresham, 2012). Based on these studies it may be inferred that coadministration of Curcuma longa with hypoglycemic drugs (especially CYP2C19, CYP2C9 enzymes substrates) with narrow therapeutic range can alter their pharmacokinetic and pharmacodynamic profile, resulting in significant HDI.…”

Section: Selection Criterionmentioning

confidence: 99%

Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data

Thikekar

Thomas

Chitlange

2021

Phytotherapy Research

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Global diabetes epidemic is the major cause of fatality and lethality. As per IDF 2019 report, diabetes caused 4.2 million deaths, approximately 463 million people are living with diabetes and by 2045, this will rise to 700 million. Nowadays, the physicians and common people in both developed and developing countries are using medicinal plants and their formulations to treat diseases with the postulation that organic commodities are safe for consumption. These plants may act as inhibitors or inducers of the Cytochrome P450 or transport and efflux proteins or both and may alter gastrointestinal, renal functions leading to Herb‐Drug Interactions. This review intends to focus on the frequently employed medicinal plants, their traditional uses, their Cytochrome P450 inhibition or induction activity, phytochemical, and pharmacological effects, established HDI with the help of in vitro tools, in vivo pharmacokinetics and pharmacodynamics studies to understand the impact of herbs on ADME of the drug and whether it is beneficial, harmful or has no effect respectively. This review will help the physicians and other health care professionals as a reference guide to update their knowledge and expertise about HDI. However, more quality research in this area is needed to evaluate the efficacy of many herbal medicines, thereby reducing side effects and improving the safety of patients.

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Pharmacokinetic and Pharmacodynamic Interaction of Curcumin with Glimepiride in Normal and Diabetic Rats

Cited by 5 publications

References 16 publications

Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits

Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits

Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus

Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data

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