Antidiabetic Activity of Afobazole in Wistar Rats

Ostrovskaya, R. U.; Ivanov, S. V.; Voronin, M. V.; Ozerova, I. V.; Zolotov, N. N.; Seredenin, S. B.

doi:10.1007/s10517-018-4233-4

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…Benzimidazoles are group of medications mostly used as anti-helminthic. It was reported that they have hypoglycemic activity mediated by augmenting insulin secretion and activity[ 151 , 152 ].…”

Section: Antimicrobials With Anti-diabetic Activitymentioning

confidence: 99%

Anti-diabetics and antimicrobials: Harmony of mutual interplay

Hegazy¹,

Rajab²,

Lila³

et al. 2021

WJD

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Diabetes is one of the four major non-communicable diseases, and appointed by the world health organization as the seventh leading cause of death worldwide. The scientists have turned over every rock in the corners of medical sciences in order to come up with better understanding and hence more effective treatments of diabetes. The continuous research on the subject has elucidated the role of immune disorders and inflammation as definitive factors in the trajectory of diabetes, assuring that blood glucose adjustments would result in a relief in the systemic stress leading to minimizing inflammation. On a parallel basis, microbial infections usually take advantage of immunity disorders and propagate creating a pro-inflammatory environment, all of which can be reversed by antimicrobial treatment. Standing at the crossroads between diabetes, immunity and infection, we aim in this review at projecting the interplay between immunity and diabetes, shedding the light on the overlapping playgrounds for the activity of some antimicrobial and anti-diabetic agents. Furthermore, we focused on the anti-diabetic drugs that can confer antimicrobial or anti-virulence activities.

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Section: Antimicrobials With Anti-diabetic Activitymentioning

confidence: 99%

Anti-diabetics and antimicrobials: Harmony of mutual interplay

Hegazy¹,

Rajab²,

Lila³

et al. 2021

WJD

View full text Add to dashboard Cite

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Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes

et al. 2020

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Assessment of ethylthiobenzimidazole and fabomotizole activity in a model of hypercapnic hypoxia with cutting off the brain hemispheres work

Marysheva

Mikheev

Shabanov

2022

Rev Clin Pharm Drug Ther

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BACKGROUND: Resistance to hypoxia depends on the type of animal, its condition (fatigue, pre-exposure, pregnancy in females) and the conditions of the experiments. AIM: study the effect of ethylthiobenzimidazole (Metaprot, Bemityl) and fabomotizole (Afobazole), which were antihypoxants with an isothiourea group, on the resistance of male outbred mice to acute hypoxia with hypercapnia under conditions of isolated functioning of one of the cerebral hemispheres. MATERIALS AND METHODS: Acute hypoxia with hypercapnia was simulated by the cupping method by placing male mice in a closed hermetic volume (200 cm3) until the death of the animal. Previously, in some mice, one of the cerebral hemispheres was temporarily switched off according to the Leao method. RESULTS: It has been shown that ethylthiobenzimidazole and fabomotizole, administered intraperitoneally in equimolar doses (25 and 32.8 mg/kg, respectively) 30 min before a hypoxic episode, increase the life time of experimental animals when either of the hemispheres (right or left) is turned off approximately equally. CONCLUSIONS: Data are considered in terms of the possibility of using both drugs in the prevention and treatment of ischemic strokes.

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Antidiabetic Activity of Afobazole in Wistar Rats

Cited by 4 publications

References 11 publications

Anti-diabetics and antimicrobials: Harmony of mutual interplay

Anti-diabetics and antimicrobials: Harmony of mutual interplay

Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes

Assessment of ethylthiobenzimidazole and fabomotizole activity in a model of hypercapnic hypoxia with cutting off the brain hemispheres work

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