Antidepressive, antinociceptive and immunomodulatory effects of aqueous and proteic extracts of Berberishispanica Boiss. &amp; Reut. from Morocco

Youbi, Amal El Hamsas El; Bousta, Dalila; Ouahidi, Ibtissam; Aarab, Lotfi

doi:10.1007/s10298-010-0606-1

Cited by 7 publications

(2 citation statements)

References 38 publications

(41 reference statements)

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“…Berberis possesses many medicinal properties since it has been used in the treatment of diseases including leishmaniasis, heart disease, cholecystitis, hypertension, colds, cholelithiasis, dysentery, gallstones, digestive ailments, jaundice, malaria, ischemic heart disease, cardiomyopathies, and urinary tract problems [6][7][8][9][10]. The Spanish barberry is used in traditional medicine to cure gastrointestinal stones, inflammation, liver, and biliary disorders [11]. Genus Berberisis is rich in compounds including tamarixetin, rutin, caffeic, and chlorogenic acids with bioactivity potential.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Understanding the Anticancer Properties in Human Prostate and Breast Cancer Cell Lines of Chemically Characterized Methanol Extract from Berberis hispanica Boiss. & Reut

et al. 2021

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The current research was conducted to investigate the chemical profile, antiproliferative, and antioxidant activities of methanol extracts obtained by two different methods including maceration and Soxhlet from Berberis hispanica Boiss. & Reut. Antiproliferative activities were evaluated by the MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay in four human cancer cell lines including prostate (LnCap and 22 RV1) and breast cancer (MDA-MB-231 and MCF7). The antioxidant power was evaluated by DPPH ((2,2-diphenyl-1-picryl-hydrazyl-hydrate), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and FRAPS (Ferric reducing antioxidant power) tests. The chemical composition was conducted by gas chromatography-mass spectrometry (GC-MS) after methylation. Total phenolic and flavonoid contents were assessed using the Folin–Ciocalteu method. The phytochemical analysis showed that the tested extracts possessed inserting potentially active compounds. The MTT test revealed that both extracts (maceration and Soxhlet) reduced cell viability in all cell lines tested. In breast cancer cell lines MDA-MB-231 and MCF-7, the IC50 values obtained by maceration were 16.55 ± 0.58 and 17.95 ± 0.58 µg/mL, respectively. These values were slightly lower than those obtained with the Soxhlet extract toward MDA-MB-231 (19.93 ± 0.74 µg/mL) and MCF-7 (20.22 ± 0.89 µg/mL). Regarding prostate cancer cells 22 RV and LnCap, the IC50 values obtained by maceration extract (22 RV: 11.75 ± 0.35 µg/mL; LnCap: 11.91 ± 0.54 µg/mL) were also slightly lower than those obtained with Soxhlet (22 RV: 13.47 ± 0.52 µg/mL; LnCap: 19.64 ± 1.05 µg/mL). The antioxidant activity showed that the studied extracts had considerable antioxidant activity (DPPH, FRAP, and ABTS) with particular attention to the extract obtained with maceration. The Berberis hispanica Bois. and Reut. can serve society as it provides potentially bioactive compounds that may find application in the medical sector to control such diseases.

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Section: Introductionmentioning

confidence: 99%

“…However, the available results on its chemical composition are more limited [10,12]. These compounds are responsible for Berberis biological activities such as antidepressant, antinociceptive, and immunomodulation effects [11,13].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Understanding the Anticancer Properties in Human Prostate and Breast Cancer Cell Lines of Chemically Characterized Methanol Extract from Berberis hispanica Boiss. & Reut

et al. 2021

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L’Institut national des plantes médicinales et aromatiques au service du développement de la phytothérapie au Maroc

Bousta

Ennabili

2011

Phytothérapie

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Au Maroc, la phytothérapie est une pratique très ancienne ; elle y doit énormément à la médecine « araboislamique », même si des non-musulmans, juifs et chrétiens notamment, ont joué un rôle important. Les connaissances empiriques se sont transmises verbalement à travers les générations et se sont enrichies grâce à la situation géogra-phique stratégique bien connue du Maroc (diversité bioclimatique et brassage des civilisations à travers l'histoire). À l'heure actuelle, les plantes médicinales peuvent nous apporter des solutions intéressantes aux contraintes liées à la santé surtout dans des pays en voie de développement. La promotion de la phytothérapie nous permettra de sauvegarder le savoir de nos ancêtres qui tend à disparaître. De par ses missions, l'Institut national des plantes médicinales et aromatiques-Maroc, tend à contribuer à l'élaboration de nouveaux médicaments naturels en étroite collaboration avec des décideurs de ce secteur pour sauvegarder la biodiversité végétale d'une part, et contrôler l'innocuité et la qualité des sous-produits de la médecine traditionnelle d'autre part.Abstract: In Morocco, phytotherapy is an ancient practice, which owes greatly to the "Arabo-Islamic" medicine, even if non-Muslims, Jews and Christian particularly, have played an important part in this regard. Empirical knowledge has been passed down orally through the generations and has been enriched thanks to the strategic geographical situation of Morocco (bioclimatic diversity and civilizations brewing through history). Currently, traditional medicine can give us interesting solutions to the constraints related to health especially in developing countries. The promotion of phytotherapy will help us to save the knowledge of our ancestors, which tends to disappear. Through its missions, the National Institute of Medicinal and Aromatic PlantsMorocco attempts to contribute to the development of new natural drugs, closely with decision-makers from this sector to protect plant biodiversity, and control the safety and quality of sub-products used in traditional medicine.

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Activités antioxydante, apoptotique et antiproliférative de Tetraena gaetula (Emb. & Maire) Beier & Thulin et de Berberis hispanica Boiss. & Reut. originaires du Maroc

Youbi

Bousta

Jamoussi³

et al. 2012

Phytothérapie

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Antidepressive, antinociceptive and immunomodulatory effects of aqueous and proteic extracts of Berberishispanica Boiss. & Reut. from Morocco

Cited by 7 publications

References 38 publications

Antioxidant and Understanding the Anticancer Properties in Human Prostate and Breast Cancer Cell Lines of Chemically Characterized Methanol Extract from Berberis hispanica Boiss. & Reut

Antioxidant and Understanding the Anticancer Properties in Human Prostate and Breast Cancer Cell Lines of Chemically Characterized Methanol Extract from Berberis hispanica Boiss. & Reut

L’Institut national des plantes médicinales et aromatiques au service du développement de la phytothérapie au Maroc

Activités antioxydante, apoptotique et antiproliférative de Tetraena gaetula (Emb. & Maire) Beier & Thulin et de Berberis hispanica Boiss. & Reut. originaires du Maroc

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