Antidepressant-like effects of tramadol and other central analgesics with activity on monoamines reuptake, in helpless rats

Rojas-Corrales, M.O.; Berrocoso, Esther; Gibert-Rahola, J.; Micó, Juan Antonio

doi:10.1016/s0024-3205(02)02220-8

Cited by 96 publications

(51 citation statements)

References 38 publications

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“…The antidepressant effects of many analgesic drugs have been observed in clinical and experimental animal studies [21][22][23][24][25][26][27]. Tramadol and some opioid agonists have been declared to improve depressive symptoms [22,23].…”

Section: Discussionmentioning

confidence: 99%

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Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Kıroğlu¹,

Demirkol²,

Berktaş³

et al. 2016

CIM

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Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences Abstract Purpose: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects.Methods: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks. Dipyrone was administered intraperitoneally beginning from the third week. Splash, rota-rod (RR) and forced swimming (FST) tests were performed at the seventh week as behavioural tests to evaluate the antidepressant-like effects of dipyrone. Coat state score (CSS) and weights of animals were recorded at seventh weeks. Results were analyzed using one or two-way ANOVA followed by the Bonferonni post hoc test.Results: Weight of UCMS-exposed mice did not change compared with controls; however, significant changes were observed in CSS in both sexes of stressed mice (p<0.05). RR latency decreased and immobility time enhanced in FST test in both sexes of stressed mice (p<0.05). Grooming behaviour was not different between the groups in female mice, but different in male mice in the splash test. Dipyrone did not produce a significant change in CSS in the UCMS-exposed group but reversed the latency time and immobility time to normal values in both sexes of mice and augmented the number of grooming behaviour only in stressed male mice. Conclusion:These results indicate that dipyrone produce antidepressant-like effects to some symptoms of UCMS according to gender.SUPPLEMENT

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Section: Discussionmentioning

confidence: 99%

“…Tramadol and some opioid agonists have been declared to improve depressive symptoms [22,23]. Celecoxib and piroxicam have been shown to display antidepressant effect in human and animal studies [8,[24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Kıroğlu¹,

Demirkol²,

Berktaş³

et al. 2016

CIM

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“…As opioid and monoaminergic systems appear to share common molecular mechanisms mediating nociception, opioid compounds are frequently coadministrated with antidepressants for pain relief. However, the validity of this therapeutic strategy for the treatment of mood disorders with comorbid pain remains unclear (Alba- Delgado et al, 2011;Berrocoso & Mico, 2009a;Rojas-Corrales et al, 2002;. Moreover, the opioid doses required to produce antidepressant-like effects are higher than those required to produce analgesic effects, suggesting that these two processes are mediated by distinct mechanisms (Berrocoso & Mico, 2009a;Rodriguez-Munoz et al, 2011).…”

Section: The Opioid Systemmentioning

confidence: 99%

Antidepressant Drugs and Pain

Cobo-Realpe¹,

Alba-Delgado²,

Bravo³

et al. 2012

Effects of Antidepressants

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“…5 Few of the previous studies evaluated tramadol which exhibited anti depressant activity in mice using different experimental model of depression. 6 A study showed that tramadol reduced the number of failures to avoid aversion in learned helplessness model in rats. 6 However there was no agreement on the doses at which the effects were evident.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

Bonda

Pawar

Lokhande

2017

Int J Basic Clin Pharmacol

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Background: The aim of the study was to evaluate the antidepressant effect of opioid analgesic tramadol using forced swim test and tail suspension test models.Methods: The antidepressant effect was assessed by recording the immobility time in Forced swim test (FST) and Tail suspension test (TST). The mice were randomly divided into five groups. Mice belonging to group I was given normal saline (0.1ml/kg) which acted as control. Group II received imipramine (15mg/kg) considered as the standard drug tramadol was given in graded dose (10, 20 and 40 mg/kg) to mice of groups III, IV, V respectively. All drugs were administered intraperitoneally for seven successive days; test was done on 7th day.Results: Tramadol and Imipramine showed antidepressant activity when compared to control. There is dose dependent increase in antidepressant activity of tramadol. The antidepressant activity of imipramine was significantly (P<0.05) more than tramadol at dose 10 and 20 mg/kg but antidepressant activity with tramadol 40mg/kg was comparable to imipramine treated mice.Conclusions: The results of this study indicated the presence of antidepressant activity of tramadol at 40mg/kg.

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Antidepressant-like effects of tramadol and other central analgesics with activity on monoamines reuptake, in helpless rats

Cited by 96 publications

References 38 publications

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Antidepressant Drugs and Pain

Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

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