Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

Bonda, Chiranjeevi; Pawar, Sudhir; Lokhande, Jaisen

doi:10.18203/2319-2003.ijbcp20170839

Cited by 2 publications

(3 citation statements)

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“…Further preclinical studies are needed to explore the effect of different administration regimes and the efficacy of tramadol in other types of depression tests. 18,19 This research only investigated the effect of tramadol in a standardized singular dosage regimen; however, others have studied the effect at different doses. One such research revealed that tramadol produced significant antidepressant effect at three different doses and that the antidepressant effect of tramadol at doses of 10 and 20 mg/kg was comparable with that of fluoxetine.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Few of the previous studies evaluated tramadol which exhibited antidepressant activity in mice using different experimental model of depression. 14,15 If tramadol is to be proposed as a viable adjunct, more detailed animal testing must be done prior to human trials. [11] This research investigates the antidepressant and anti-anxiety effects of Tramadol and compares it with imipramine (approved / commercially available anti-depressant) in forced swimming and elevated maze test animal models within 24 hours (acute dosing) and 15 days (chronic dosing).…”

Section: Correspondencementioning

confidence: 99%

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Antidepressant and Anxiolytic Effect of Tramadol as Compared to Imipramine, in Acute and Chronic Dosage in Rats

Soomro¹,

Kazi²,

Rajput³

et al. 2022

JAFMDC

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Objective: To assess the anti-depressant and anxiolytic effect of tramadol as compared to imipramine (approved antidepressant) in acute and chronic doses in rats.Methodology: This observational experimental animal study was carried out from December 2020 to February 2021 at Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro in collaboration with Agricultural University, Tandojam. Forty- eight healthy male rats housed at Animal House Sindh, Agricultural University, Tandojam after due approval from institutional ethical review board. The 48 rats were categorized into 3 equal groups of 16 each: Group A for Normal saline (0.9% NaCl) 15ml/kg, Group B for Imipramine 15 mg/kg and Group C for Tramadol 15 mg/kg. Each group was further subdivided into two groups namely acute A1, B1, C1 and chronic A2, B2, C2 and evaluated for anti-depressant and anxiety activity using forced swim test and elevated plus maze test. The data obtained was analyzed using SPSS. 22.0.Results: Tramadol acted to significantly reduce the mean duration of immobility as compared to the control (P<0.001). Resolution of immobility due to tramadol was insignificant when compared to imipramine. Likewise, the swimming periods in the tramadol and imipramine groups were significantly longer than the control group (<0.001), but almost equal in both tramadol and imipramine groups, showcasing that tramadol has antidepressant activity at par with imipramine (p value >0.05).Conclusion: Tramadol exhibits significant acute and chronic antidepressant and anxiolytic effects in rats when compared to imipramine and controls.

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Section: Discussionmentioning

confidence: 99%

Section: Correspondencementioning

confidence: 99%

Antidepressant and Anxiolytic Effect of Tramadol as Compared to Imipramine, in Acute and Chronic Dosage in Rats

Soomro¹,

Kazi²,

Rajput³

et al. 2022

JAFMDC

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“…15 196.33 Bonda C et al, compared the antidepressant activity of tramadol with imipramine and we also did the same. 16 They reported that as the dose of tramadol increased, the antidepressant activity of tramadol increased. Authors also found that as the dose of tramadol increased, the antidepressant activity of tramadol increased.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antidepressant activity of tramadol in albino mice using forced swim model

Ramachandra

Jayalakshmi

2019

Int J Basic Clin Pharmacol

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Background: The fact that tramadol can be used as an antidepressant, has been already proved by some animal studies. The objective of the present study was to evaluate antidepressant activity of tramadol in albino mice using forced swim model.Methods: Forced swimming test (FST) model was used to evaluate the antidepressant effect. Mice in the group "I" were given normal saline. Mice in the group II were given imipramine. Mice in the group III were given tramadol 10mg/kg. Mice in the group IV were given tramadol 20mg/kg. Mice in the group V were given tramadol 40mg/kg. All doses in all groups were given by intra peritoneum route.Results: The average values of immobility in group I were higher significantly compared to group III, IV and V. The values of group I and group II were found to be comparable. It was found that the baseline mean value was 196.33 which reduced to 5.16 with the effect of imipramine where imipramine was given to those mice. But in tramadol 10mg group, it was highest, and it came down to 40.66 and as the dose of tramadol was increased, the immobility time reduced from 40.66 at 10mg dose to 31.33 at 20mg dose and finally to 13.33mg at 40mg dose.Conclusions: Considering the results of two different animal models of depression it can be concluded that Tramadol has antidepressant activity at 10mg, 20mg, 40mg which was almost similar to Imipramine.

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Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

Cited by 2 publications

References 9 publications

Antidepressant and Anxiolytic Effect of Tramadol as Compared to Imipramine, in Acute and Chronic Dosage in Rats

Antidepressant and Anxiolytic Effect of Tramadol as Compared to Imipramine, in Acute and Chronic Dosage in Rats

Evaluation of antidepressant activity of tramadol in albino mice using forced swim model

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