Antidepressant-like and toxicological effects of a standardized aqueous extract of Chrysactinia mexicana A. Gray (Asteraceae) in mice

Cassani, Julia; Ferreyra-Cruz, Octavio Alberto; Dorantes-Barrón, Ana María; Villaseñor, Rosa María Vigueras; Arrieta-Báez, Daniel; Estrada-Reyes, Rosa

doi:10.1016/j.jep.2015.05.055

Cited by 33 publications

(28 citation statements)

References 26 publications

(21 reference statements)

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“…The importance of this family is widely supported by different studies [45] reporting a rich number of species and uses (medicinal, agricultural, and industrial). The phytochemical components present in flavonoids, sapogenins, mucilage, essential oils, and glucoalcohols are used in folk medicine to treat condition fever and rheumatism [48,49] and used as a diuretic, an antispasmodic, a general tonic, a stimulating agent, and an antidepressant [49,50]. After Asteraceae, Fabaceae and Laminaceae were the most dominant families used for medicine by Mexican communities [16,18], as well as in other parts of the world (e.g., Ethiopia [51], Pakistan [27]).…”

Section: Discussionmentioning

confidence: 99%

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

et al. 2018

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Despite the fact that Mexico has vast biocultural biodiversity, there are numerous regions where the traditional medicinal use of plants has not yet been studied. We aimed to document, analyze quantitatively, and preserve medicinal plant knowledge among local people living in over 40 communities in the state of Zacatecas. Ethnobotanical information was collected by semistructured interviews with 132 informants. Data were analyzed using standard quantitative indices such as relative frequency of citation, family importance value, cultural importance index, and informant consensus factor. We recorded 168 medicinal plant taxa belonging to 151 genera and 69 botanical families and used to treat 99 health disorders. The most medicinally important plant families were Asteraceae (20 species), followed by Fabaceae and Lamiaceae (12 species) and Cactaceae (five species). The most culturally important species was Matricaria chamomilla L., mentioned 140 times, followed by Arnica montana L. (62 times) and Artemisia ludoviciana Nutt (48 times). The highest consensus for use was for diseases of the reproductive system. The type of disorder for which there was the highest number of references for use (389; 25% of all uses) and plant species (67) were diseases of the digestive and gastrointestinal system. The present study represents the first quantitative medical-ethnobotanical documentation and analysis of the traditional use of medicinal plants in Zacatecas state. Despite the semiarid climate, this region is botanically highly diverse, and its flora have versatile medicinal uses.

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Section: Discussionmentioning

confidence: 99%

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

et al. 2018

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“…The body's weight and organs' relative weights are among the indices investigated in toxicological studies. These indices did not decrease due to the use of C. mexicana extract with no injuries or pathological variations in vital organs (Cassani et al, 2015). Therefore, the toxic effects of medicinal plants and their active compounds are recommended to be studied to confirm the safety of use.…”

Section: Discussionmentioning

confidence: 99%

“…The observed antidepressant effects for C. mexicana can be due to phenylpropanoids including caffeic acid, coumaric acid and fruolic acid (Cassani et al, 2015). The antidepressant effects of fruolic acid and caffeic acid have already been demonstrated (Zeni et al, 2012).…”

Section: Chrystactinia Mexicanamentioning

confidence: 99%

“…mexicana is widely used in North America, Mexico, and some South American countries to treat diseases. According to Mexican traditional medicine, C. mexicana is used to treat fever and rheumatism and as diuretic, sexual enhancer, anticonvulsant, stimulant, and tonic (Cassani et al, 2015). Cassani et al investigated the antidepressant effects of aqueous C. mexicana extract in mice using forced swim test and tail suspension test, and found this extract's antidepressant effects to be similar to those of a conventional antidepressant, clomipramine (Cassani et al, 2015).…”

Section: Chrystactinia Mexicanamentioning

confidence: 99%

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A review on antidepressant effect of medicinal plants

Rabiei

2017

Bangladesh J Pharmacol

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<p class="Abstract">Depression is a life-threatening, debilitating, and common disease affecting different segments of community. Chemical and synthetic drugs available to treat this disease cause many adverse effects and may lead to complete recovery in only 50% of patients. At the same time, medicinal plants have been reported to exert optimal pharmacological effects in treating depression in different models. In this review, the relevant articles indexed in the reliable databases PubMed, PubMed central, Scopus and Web of Science were review-ed. The review indicated that most medicinal plants exerted antidepressant effects through synaptic regulation of serotonin, noradrenaline, and dopamine, regulating activity of hypothalamic-pituitary-adrenal axis, reinfor-cing anti-oxidant defense system, and decreasing inflammatory mediators. The medicinal plants and their active compounds can relieve depression through different pathways and hence are considered a new source to produce antidepressants.</p>

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“…The sample and standards (1 mg mL -1 ) were injected (10 µL). Then, a concentration-absorbance relationship for each standard was established: y caffeic acid = 160.88x + 146 (r (Cassani et al, 2015).…”

Section: Polyphenols Identification and Quantitation By Tlc And Hplc-mentioning

confidence: 99%

Perfil de polifenoles, capacidad antioxidante y efecto citotóxico in vitro en líneas celulares humanas de un extracto hidroalcohólico de pétalos de Calendula officinalis L.

et al. 2018

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ARTÍCULO ORIGINAL abstractThe hydro-alcoholic extract from Calendula officinalis petals, was evaluated showing beneficial effects against oxidative stress and therefore on diseases associated to inflammatory processes. The content of polyphenols of the extract was determined by TLC and HPLC-UV-DAD and the antioxidant efficiency estimated from Fe 3+ /Fe 2+ reducing power, Cu 2+and Fe 2+ chelation,• OH radical scavenging, ABTS [2, 2´-azino bis (3 ethylbenzothiazoline-6-sulphonic acid)] and DPPH (2,2´diphenyl-1-picrylhydrazyl) assays. The in vitro growth inhibition (IC 50 ) in human cancer cell breast (MDA-MB-231), uterine cervix (HeLa), lung (A-549), colon (HT-29) and (Caco-2) was determined by MTT method. The extract showed that the polyphenols content in the hydro-alcoholic extract was 37.01±0.015 mg GAE g -1 , being rutin the most abundant one. ABTS TEAC and DPPH TEAC tests showed a high antioxidant capacity. The antioxidant activity profile displayed high reducing capacity and ability to chelate Cu 2+ and Fe 2+ as well as good• OH radical scavenging capacity. The extract showed a cytotoxic effect on human cancer cell lines of colon (HT-29) and (Caco-2), breast (MDA-MB-231), uterine cervix (HeLa), and lung (A-549) (IC 50 = 10.84, 11.73, 11.26, 11.53, and 11.96 µg mL -1 , respectively). The correlation analysis suggests that the Calendula officinalis polyphenols are directly related to the antioxidant efficiency of the extract and inversely to the cell viability.Key Words: Calendula officinalis, polyphenols, antioxidant, cytotoxicity. OH, y ensayos ABTS [2, 2´-azino-bis (3 etilbenzotiazolin-6-sulfónico) y DPPH (2,2´difenil-1-picrilhidracilo). La inhibición del crecimiento in vitro (IC 50 ) en células cancerosas humanas de mama (MDA-MB-231), de cuello uterino (HeLa) , pulmón (A-549) , y colon (HT-29 y Caco-2), fue determinado por el método de MTT. El extracto mostró que el contenido total de polifenoles fue de 37.01±0.015 mg GAe g -1 , siendo la rutina la más abundante. Las pruebas ABTS TEAC y DPPH TEAC mostraron una alta capacidad antioxidante. El perfil de actividad antioxidante mostró buena capacidad reductora y capacidad para quelar Cu 2+ y Fe 2+, así como una buena capacidad de eliminación de radicales • OH. El extracto también mostró efecto citotóxico en células de colon (HT-29 y Caco-2) , de mama (MDA-MB-231), de cuello uterino (HeLa) y pulmón (A-549) (IC 50 = 10.84, 11.73, 11.26, 11.53 y 11.96 μg mL -1 , respectivamente). El análisis de correlación sugiere que los polifenoles de Calendula officinalis están directamente relacionados con la capacidad antioxidante del extracto y se asocian inversamente con la viabilidad celular.Palabras Clave: Calendula officinalis, polifenoles, antioxidante, citotoxicidad.

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Antidepressant-like and toxicological effects of a standardized aqueous extract of Chrysactinia mexicana A. Gray (Asteraceae) in mice

Cited by 33 publications

References 26 publications

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

A review on antidepressant effect of medicinal plants

Perfil de polifenoles, capacidad antioxidante y efecto citotóxico in vitro en líneas celulares humanas de un extracto hidroalcohólico de pétalos de Calendula officinalis L.

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