Antidepressant-like activity of methyl jasmonate involves modulation of monoaminergic pathways in mice

Umukoro, Solomon; Adebesin, Adaeze; Agu, G. O.; Omorogbe, Osarume; Asehinde, Stephen

doi:10.1016/j.advms.2017.07.005

Cited by 23 publications

(23 citation statements)

References 41 publications

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“…In this study, intraperitoneal administration of naringin was found to significantly decrease the duration of immobility of mice in the FST and TST in comparison with vehicle controls, which indicates antidepressant-like property. This finding further supports previous investigations, which showed that anti-depressants reduced the immobility time of rodents in the FST and TST [36,40,41]. However, the anti-depressant property of naringin was not associated with CNS stimulation; as it did not cause any significant change in spontaneous motor activity in mice.…”

Section: Discussionsupporting

confidence: 91%

“…The FST and TST-induced immobility are widely use behavioral despair models of depression; for the evaluation of compounds with potential anti-depressant-like property in rodents [36,37,40]. The state of immobility is indicative of behavioral despair in rodents and the reduction in the duration of immobility serves as selective and specific marker of anti-depressant-like property [37,41].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Neurobehavioral Properties of Naringin in Swiss Mice

et al. 2018

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Evaluation of the Neurobehavioral Properties of Naringin in Swiss Mice

et al. 2018

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“…Immobility is one of the variables in FST and TST that indicate hopeless and depressive behavior of the animal. Reduction in immobility period shows anti-depressant potential [25]. When compared with control, 125 and 250 mg/kg have shown reduction in duration of immobility however, these doses increase the duration of swimming which in turn counter balance the immobility duration.…”

Section: Discussionmentioning

confidence: 94%

Screening of Anxiolytic and Antidepressant of Methanolic Leaves Extract of Syzygium Cumini in Mice

Rehman

Riaz

Asghar

et al. 2020

RADS J. Pharm. Pharm. Sci.

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Background: Anxiety and depression are very common in clinical practice and reduce the overall quality of life. In recent years, various researchers have focused on natural products which are derived from medicinal plants. Studies suggested that diet rich in flavonoids, vitamins and antioxidants are the important components in reduction of anxiety and depression. Objective: Hence current investigation was aimed to assess the anxiolytic and antidepressant effects of Syzygium cumini in mice at 125, 250 and 500 mg/kg. Methods: These effects were mainly evaluated twice at 8th and 15th days by elevated plus maze, open field test, forced swimming test and tail suspension test. Results and Conclusion: In open field test S. cumini showed escalation rearing in numbers and its duration which indicates improved exploratory behavior and locomotor activity of the animals. In EPM, there was increase in entries numbers and time spent in open arm. Decrease in immobility duration observed at low dose while high dose increased immobility duration in FST. Hence outcomes of current study indicate that S. cumini have anxiolytic and anti-depressant effect.

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“…Some of these are effective in the treatment of neurological diseases; some are useful for cardiovascular, respiratory, and gastrointestinal diseases while others have chemotherapeutic and antibacterial effects. Some of the important phytochemicals of the plants (Table 4) including alkaloids (like nicotine and scopolamine) are reported to have anxiolytic, antidepressant, and anti-Parkinson activities [15][16][17][18], saponins (like bacosides) have been reported for anxiolytic, antiepileptic, antiamnesia, and neuroprotective and memory enhancement activities [19][20][21][22], terpenoids (like cannabigerol, tetrahydrocannabinol, and cannabidiol) are reported for their neuroprotective effects [23], flavonoids (like kaempferol, luteolin, quercetin, rutin, and hesperidin) have been reported for their anxiolytic, antidepressant, antiepileptic, anti-Alzheimer, and neuroprotective and memory enhancement activities [24][25][26][27][28][29][30], glycosides (like hastatoside and verbenalin) are reported for sleep promoting activity [31], steroids (like sitoindosides VII-X and withaferin-A) have been reported for anxiolytic activity [32].…”

Section: Resultsmentioning

confidence: 99%

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

Khan

Shah

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Almost every region of Pakistan is stacked with a large number of medicinal plants. Due to high cost and unavailability of allopathic medicines for the neurological diseases, especially in rural areas, traditional healers prescribe phytotherapy for various neurological diseases like epilepsy, depression, anxiety, insomnia, Alzheimer, and migraine. Such treatments are considered to be most effective by the native people. Methods. The data was collected from articles published on medicinal plants of various districts of Pakistan, using article search engines like Medline, Pubmed, Web of Science, Science Direct, and Google Scholar. Also, information regarding various neurological uses and mode of applications of medicinal plants was obtained from traditional healers, folk medicine users, and local elderly people having knowledge of medicinal plants. Results. A total of 54 families were found to be used in various neurological diseases, of which the highest use was of Solanaceae (22.22%), Asteraceae (12.96%), Lamiaceae, Papaveraceae, and Poaceae, 9% each, and Caprifoliaceae, Cucurbitaceae, Rhamnaceae, and Rosaceae, 5.5% each. According to districts, 15% of plants that were effective in neurological affections were found in Bahawalpur, 11% in Swat, 8% in Muzaffarabad, 7% in Malakand, and 6% in Bahawalnagar, Dir, Gilgat, and Sarghoda each, with 5% in Dera ghazi khan and Jhelum each. According to the plant’s habit, out of total of 103 plants, 61.15% were found to be herbs, 22.33% trees, 11.65% shrubs, and 4.85% climbers. According to the part used of plant, whole plant, leaves, fruits, roots, seeds, and flowers were found to be used 32.03%, 24.27%, 20.38%, 16.50%, 13.59%, and 11.65%, respectively. According to disease’s types, 45.63% were found to be effective in insomnia, 31.06% in epilepsy 12.62% in depression, 6.80% in anxiety, 7.77% in hysteria, and 5.88% in migraine. Conclusion. Taking into consideration this useful knowledge on medicinal properties of the plants for curing neurologic diseases, it is believed that research in areas of ethnomedicine and ethnopharmacology can bring auspicious results that have potential of adding value to the very rich natural resources of Pakistan. This study will help all the researchers from diverse backgrounds working on plants based medicine for neurological diseases.

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Antidepressant-like activity of methyl jasmonate involves modulation of monoaminergic pathways in mice

Cited by 23 publications

References 41 publications

Evaluation of the Neurobehavioral Properties of Naringin in Swiss Mice

Evaluation of the Neurobehavioral Properties of Naringin in Swiss Mice

Screening of Anxiolytic and Antidepressant of Methanolic Leaves Extract of Syzygium Cumini in Mice

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

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