Antidepressant Effect of Baicalin Extracted from the Root of<i>Scutellaria baicalensis</i>. in Mice and Rats

Zhu, Weili; Ma, Shengming; Qu, Rong; Kang, Dali; Liu, Yadong

doi:10.1080/13880200600878684

Cited by 35 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Baikal skullcap roots and isolated flavonoids have a wide range of pharmacological uses and bioactivity (Heo et al, 2004;Hwang et al, 2005;Kimura, 2005), and have been used in traditional medicine in Russia, China, and other countries. Research has found that baicalin and baicalein may exhibit anti-HIV activity (Wu et al, 2001), may reduce susceptibility to HIV-1 infection (Li et al, 2000), may have anticancer activity (Ciesielska et al, 2002;Ye et al, 2002), can have protective effects against cytotoxicity and genotoxicity (Hwang et al, 2005), have antioxidant effects (Ciesielska et al, 2002;Shao et al, 2004), and exhibit antidepressant activity (Zhu et al, 2006). Research has also suggested that baicalin and baicalein might also have a potential for chemoprevention of Alzheimer's disease (Heo et al, 2004).…”

mentioning

confidence: 99%

Quality Assessment and Yield of Baikal Skullcap (Scutellaria baicalensis) Grown at Multiple Locations

Zheljazkov¹,

Cantrell²,

Ebelhar³

et al. 2007

horts

View full text Add to dashboard Cite

Baikal skullcap (Scutellaria baicalensis) is an important medicinal plant with proven bioactivity. Commercially available products in the United States containing extracts or derivatives from this plant species have been shown to lack consistency of chemical composition and bioactivity. In the United States, these issues could be solved through domestic production of skullcap. The hypothesis of this study was that Baikal skullcap grown in the Mississippi climate would accumulate sufficient bioactive flavonoids, baicalin, and baicalein in the roots to justify domestic production, and that shoots of these plants might also contain the flavonoids of interest. A replicated field experiment was conducted at four locations in Mississippi (Beaumont, Crystal Springs, Stoneville, and Verona) to test the hypothesis. The concentration of the main flavonoid, baicalin, in the roots ranged from 8.1% to 15.6%, whereas the concentration of baicalein varied from 0.2% to 1.2%. The flavonoid concentrations in the roots were similar to that of commercially available skullcap roots, and to concentrations reported in the literature. Chrysin was detected in the roots from one location. Furthermore, the flavonoids apigenin, baicalein, baicalin, chrysin, and scutellarein were detected and quantified in the skullcap shoots. Overall, yields of dry roots tended to increase from southern to northern locations. This is the first report on flavonoid accumulation in Baikal skullcap roots and shoots grown in the United States. The results from this study are promising and suggest that 1) Baikal skullcap grown in Mississippi accumulates similar amounts of baicalein and baicalin to skullcap grown in other regions and can provide up to 128 kg·ha − 1 of baicalin and up to 2.32 kg·ha− 1 of baicalein; 2) flavonoid concentration in Baikal skullcap roots and shoots, yields, and mineral concentration of roots might depend on climatic and growing conditions; and 3) Baikal skullcap could be developed as a high-value crop for Mississippi and possibly other regions of the United States. Further research is needed on skullcap production methods and economic feasibility.

show abstract

mentioning

confidence: 99%

Quality Assessment and Yield of Baikal Skullcap (Scutellaria baicalensis) Grown at Multiple Locations

Zheljazkov¹,

Cantrell²,

Ebelhar³

et al. 2007

horts

View full text Add to dashboard Cite

show abstract

“…Although its beneficial effects were promising, the clinical use of ketamine has been hampered by its psychotomimetic character and toxicity due to drug abuse [16] . The psychotropic effects of natural products have been of interest to many clinicians and scientists due to their lack of side effects and toxicity [17,18] . Compelling research studies have shown that many types of effective components from natural products were effective agents against central nervous system diseases.…”

Section: Introductionmentioning

confidence: 99%

Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice

Zhang

Guo

et al. 2015

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: N-methyl-D-aspartic acid (NMDA) receptor modulators have shown promising results as potential antidepressant agents, whereas timosaponins extracted from the Chinese herb Rhizoma Anemarrhenae exhibit antidepressant activities. In the present study we examined whether YY-23, a modified metabolite of timosaponin B-III, could affect NMDA receptors in rat hippocampal neurons in vitro, and evaluated its antidepressant-like effects in stressed mice. Methods: NMDA-induced currents were recorded in acutely dissociated rat hippocampal CA1 neurons using a whole-cell recording technique. C57BL/6 mice were exposed to a 6-week chronic mild stress (CMS) or a 10-d chronic social defeat stress (CSDS). The stressed mice were treated with YY-23 (20 mg·kg -1 ·d -1 ) or a positive-control drug, fluoxetine (10 mg·kg -1 ·d -1 ) for 3 weeks. Behavioral assessments were carried out every week. Results: In acutely dissociated rat hippocampal CA1 neurons, YY-23 selectively and reversibly inhibited NMDA-induced currents with an EC 50 value of 2.8 μmol/L. This inhibition of NMDA-induced currents by YY-23 was non-competitive, and had no features of voltagedependency or use-dependency. Treatment of the stressed mice with YY-23 not only reversed CMS-induced deficiency of sucrose preference and immobility time, and CSDS-induced reduction of social interaction, but also had faster onset as compared to fluoxetine. Conclusion: YY-23 is a novel non-competitive antagonist of NMDA receptors with promising rapid antidepressant-like effects in mouse models of CMS and CSDS depression.

show abstract

“…In the Central Nervous System (CNS) several flavonoids bind to the benzodiazepine site on the GABAA receptor and modulate the á-aminobutyric acid (GABA)ergic system to produce the biological effect of sedation, anxiolytic or anti-convulsive (Aguirre-Hernandez et al, 2010). Flavonoids of several classes are also inhibitors of monoamine oxidase A or B (Zhu et al, 2006). Various in vivo studies have shown that flavonoids can be absorbed after oral administration, pass the blood-brain barrier and produce various effects on the CNS (Jager & Saaby, 2011).…”

Section: Introductionmentioning

confidence: 99%

Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics

Negri

Santi

Tabach

2013

Rev. bras. plantas med.

View full text Add to dashboard Cite

Tilia species, among which is Tilia cordata Mill. (Tiliaceae), have been used in folk medicine as anxiolytic. The hydroethanolic extract was analyzed by using liquid chromatography with mass spectrometry HPLC-DAD-ESI-MS/MS in negative ion mode, and its chemical composition was compared to flavonoids reported as anxiolytics. The major flavonoids found were: quercetin-3,7-di-O-rhamnoside, kaempferol-3,7-di-O-rhamnoside and kaempferol 3-O-(6"-p-coumaroyl glucoside) or tiliroside. The anxiolytic activity of the genus Tilia has been attributed to the presence of quercetin and kaempferol derivatives, while the anxiolytic activity of T. americana var. Mexicana was attributed to tiliroside, which was also found among the major constituents of this species.Key words: Tilia cordata, HPLC-DAD-ESI-MS/MS, quercetin and kaempferol glycosides, tiliroside. RESUMO:Flavonóides glicosídeos encontrados no extrato hidroalcoólico de Tilia cordata, espécie usada como ansiolítico. As espécies de Tilia, entre elas, a Tilia cordata Mill. (Tiliaceae) são utilizadas como ansiolíticas na medicina popular. O extrato hidroalcoólico foi analisado usando cromatografia líquida acoplada à espectrometria de massas HPLC-DAD-ESI/MS/ MS no modo negativo e a sua composição química foi comparada com os flavonóides já reportados como ansiolíticos. Os principais flavonóides encontrados foram: quercetina-3,7-di-O-rhamnosideo, canferol-3,7-di-O-rhamnosideo, e canferol 3-O-(6"-p-cumaroil glucosideo) ou tilirosideo. A atividade ansiolítica do gênero Tília tem sido atribuída à presença de derivados de canferol e quercetina, enquanto que a atividade ansiolítica da T. americana var. Mexicana foi atribuída ao tilirosideo, o qual também foi encontrado entre os principais constituintes desta espécie. Palavras-chave: Tilia cordata, HPLC-DAD-ESI-MS/MS, glicosídeos de quercetina e canferol, tilirosideoRev. Bras. Pl. Med., Campinas, v.15, n.2, p.217-224, 2013.

show abstract

Antidepressant Effect of Baicalin Extracted from the Root ofScutellaria baicalensis. in Mice and Rats

Cited by 35 publications

References 40 publications

Quality Assessment and Yield of Baikal Skullcap (Scutellaria baicalensis) Grown at Multiple Locations

Quality Assessment and Yield of Baikal Skullcap (Scutellaria baicalensis) Grown at Multiple Locations

Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice

Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics

Contact Info

Product

Resources

About