Antidepressant, Analgesic Activity and SAR Studies of Substituted Benzimidazoles

Abstract

ABSTRACT:Purpose. Benzimidazole class of compound is found to have diverse biological properties. From the literature study, it is observed that depression is a severe mental disease affecting a huge population and pain is affecting about 20% of world population. In continuation of our previous research work, we selected benzimidazole pharmacophore to further explore its pharmacological activities. Methods. Forced swim test and Thermal stimulus test were used to assess the antidepressant and analgesic activity of synthesized benzimidazole analogs. Results. The antidepressant activity results showed that compound 3j was found most potent having Mean ± SEM value 21.6 ± 0.8 for treated group. Furthermore, in the analgesic test, 3b, 3j, and 3o showed Mean ± SEM values; 1.8 ± 0.10, 2.3 ± 0.10 and 2.2 ± 0.10, respectively. The study results suggested that these compounds could be explored further for the development of better antidepressant and analgesic agents. Conclusion. From the present study, it may be concluded that these active benzimidazole derivatives have been found to possess potential antidepressant and analgesic activity.

Synthesis, characterization and X-ray crystal structure of copper(I) complexes of the 2-(2-quinolyl)benzothiazole ligand. Electrochemical and antibacterial studies

“…2-Substituted benzothiazoles have attracted considerable interest due to their diverse biological and pharmaceutical properties, such as antiulcer and antihelminthic [14], antihypertensive [15], anticoagulant [16], antiallergic [17], analgesic [18], anti-inflammatory [19], antimicrobial [20], antivirial [21], antiparasitic [22], anticancer [23] and enzyme inhibitory activity [24]. The increasing applications of metal complexes of 2-substituted benzothiazoles, capable of forming multifunctional complexes, in the area of optoelectronics, the synthesis of fluorogenic enzyme substrates and fluorescent materials are also well recognized [25][26][27].…”

Synthesis and Antioxidant Properties of New Benzimidazole Derivatives

“…[2][3][4][5], antiviral (anti-HIV, anti-HBV and HCV (Hepatitis B and C, etc.) [6,7], antiulcer [8,9] antiinflammatory/analgesic [10,11], antihistaminic (antiallergic) [12,13], antagonist [14], antitubercular [15], antidepressant [16], antidiabetic [17], antihypertensive [18], antioxidant [19][20][21][22] and antitumor/anticancer [23,24], have been synthesized. Also, some benzimidazole derivatives have some optical applications such as photoluminescents [25], whitening agents [26] and dye laser [27].…”

Introductory Chapter: Short Insight in Synthesis and Applications of Benzimidazole and Its Derivatives

“…Structure-activity relationship (SAR) studies have shown that 1,2,5,6-substituted benzimidazoles with various substituents are analgesic and antiinflammatory agents [22]. Also, SAR studies were accomplished for antiviral, anticancer, antihelminthic, antimicrobial, antimycobacterial, antidiabetic, antiprotozoal, antipsychotic, antidepressant, and antioxidant benzimidazole derivatives [1,[31][32][33].…”