Introductory Chapter: Short Insight in Synthesis and Applications of Benzimidazole and Its Derivatives

Recent advances in the use of benzimidazoles as corrosion inhibitors

“…The parameters implied in the adsorption of the organic inhibitors on the metal surface are: (1) the structure of the inhibitor which confers specific charges on the atoms and some type of interaction between metallic surface and organic substance; (2) the corrosive electrolyte (acid or basic); (3) nature of metal surface [82, 83]. The formation of donor–acceptor surface complexes between π-electrons of an inhibitor and the vacant d-orbital of metal was formulated in many inhibition studies [80, 84, 85]. Thus, the adsorption of the bis(benzimidazole) as neutral molecules on the metal surface can occur by displacement of water molecules from the metal surface and sharing of electrons between the nitrogen atoms and the metal surface.…”

Sunlight‐Assisted Photocatalytic Sustainable Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles and Benzimidazoles Using TiO2−Cu2(OH)PO4 Under Solvent‐Free Condition

“…[15][16][17][18][19][20] On the other hand, benzimidazoles have drawn a significant attention as an eminent and important organic building blocks in drug discovery, natural products and bioactive molecules. [21][22][23][24] For instance, benzimidazole derivatives are promising choice of pharmacophores in deriving anti-microbial, anti-ulcer, antiviral, anti-cancer, antihypertension, anti-inflammatory, and so on. [25,26] Moreover, based on optical properties of benzimidazoles based materials, they can be also used as dyes, energy storage device, chemosensors and LED applications.…”

Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases

“…Benzimidazole scaffold is a key pharmacophore in modern drug discovery [ 20 ], and its derivatives represent important bioactive molecules [ 6 ] with privileged structures in medicinal chemistry [ 21 ]. This can be very well confirmed by the increasing number of synthesized compounds which contain the benzimidazole moiety, with a wider range of therapeutic properties [ 21 , 22 ] as well as by the attempt to synthesize benzimidazole compounds with preferential geometries possessing certain biological properties [ 22 , 23 ].…”

“…A large number of benzimidazole compounds have been employed as candidates for the treatment of various types of diseases or as clinical drugs, including anticancer agents (Pracinostat, Bendamustine), antihistamine agents (Astemizole), anthelmintic agents (Albendazole, Mebendazole) [ 20 , 22 ], antibacterial agents (Ridinazole), antihypertensive agents (Candesartan), proton pump inhibitors (Pantoprazole, Ilaprazole), antiviral agents (Samatasvir) and phosphodiesterase inhibitors (Adibendan) (Fig. 1 ).…”