Anticonvulsant and anxiolytic evaluation of leaf extracts of<i>Ocimum gratissimum</i>, a culinary herb

Okoli, C. O.; Ezike, Adaobi Chioma; Agwagah, OC; Akah, P. A.

doi:10.4103/0974-8490.60580

Cited by 49 publications

(25 citation statements)

References 22 publications

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“…This plant has been prepared in a variety of forms for consumption as food spice or traditional herb in many Asian and African countries since ancient time 12-19. Recent studies also demonstrate many therapeutic activities of the OG aqueous extract (OGE), including anti-inflammation 17, 20, analgesic and spasmolytic activities 21, antidiarrheal activity 13, antihyperglycemic activity 22, and improvement of phagocytic function 23.…”

Section: Introductionmentioning

confidence: 99%

Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters

et al. 2016

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Objectives: Hyperlipidemia is a significant risk factor in the development of atherosclerosis and related diseases which are major health problem in many developed and developing countries that can lead to fatality due to the changes in lifestyle and dietary habits in this modern age.Methods: In the present study, the Ocimum gratissimum aqueous extract (OGE) was tested for the lowering effect on the serum lipid level of male hamsters on a high-fat (12%) and high-cholesterol (0.2%) diet (HFCD).Results: The results showed that the levels of serum high-density-lipoprotein-cholesterol (HDL-C) low-density-lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and triglycerols (TG) were increased in the HFCD group (113±11, 259±87, 629±175 and 625±262, respectively), as compared to the control normal diet group (51±8, 19±5, 77±16 and 101±44, respectively). When co-treated with various doses (10 and 20 mg/kg) of the OGE or rosuvastatin, the rats exhibited the restoration of normal serum LDL-C, TC, and TG levels.Conclusion: Therefore, we suggest that the Ocimum gratissimum aqueous extract may have the potential function of lowering serum lipid in rats.

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Section: Introductionmentioning

confidence: 99%

Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters

et al. 2016

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“…The parameters assessed were climbing behavior and frequency of rearing (Moore and Axton, 1998). The apormorphine induced streotypy was measured and scored as follows: 0=Absence of Stereotypy; 1=Occasional Sniffing; 2=Occasional Gnawing; 3=Frequent Gnawing; 4=Continuous Gnawing; 5=Gnawing Intensively and Staying on the Same Spot (Okoli et al, 2010a). A significant decrease in climbing scores was observed in Ficus platyphylla (Chindo et al, 2015) and Securinega virosa .…”

Section: (C) Other Behavioral Studies (I) Apormorphine Induced Strementioning

confidence: 99%

Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review

Abubakar¹,

Haque²

2019

Istanbul J Pharm

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Medicinal plants have been widely used in folklore medicine in the treatment of various diseases such as mental and neurological disorders. Mental disorders like anxiety and depression are very common among Nigerian populace. The purpose of this review was to access and evaluate several articles published on the anxiolytic and sedative properties of medicinal plants in Nigeria and to find out the gaps left for further research and drug development. Eighty-two publications available among Nigerian Universities and Research Institutes between 2008 and 2018 were selected. Seven electronic databases such as Nigerian Plant Database, HerbMed, AGRICOLA, MedlinePlus, PubMed, ScienceDirect, and Springer-Link were thoroughly explored from which 226 relevant articles were obtained using Google Scholar, Hotbot and FreeFullPdf as search engines. A number of studies conducted to test for the anxiolytic and sedative activity of medicinal plants in Nigeria were included. Articles published between 2008 and 2018 were selected. The studies were conducted in Nigeria. Research carried out before 2008 was not selected. All publications with authorship outside Nigeria were excluded. Several medicinal plants on which experiments were conducted were reported to have anxiolytic and or sedative properties in Nigeria. Several medicinal plants have shown promise as anxiolytic and sedative agents in laboratory animals' studies. The majority of these plants were used traditionally in the past to treat anxiety in Nigeria. Further research on the efficacy and safety of these medicinal plants could yield a more cost effective and perhaps safer alternative in the treatment of anxiety among Nigerians. Cite this article as: Abubakar AR, Haque M (2019). Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review. Istanbul J Pharm 49 (2): 92-104.

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“…Similarly, recent studies report leaf extracts from ethanolic and aqueous tulsi protects rats from stress-induced cardiovascular changes [48, 49]. Studies in animal models have further shown that the leaf extract of tulsi possesses anticonvulsant and anxiolytic activities [50, 51]. Several animal studies conducted over the past fifty years report that ingestion of tulsi leaves improves both glucose and lipid profiles in normal and diabetic-induced animal models [36, 38, 52–58].…”

Section: Introductionmentioning

confidence: 99%

The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature

Jamshidi

Cohen

2017

Evidence-Based Complementary and Alternative Medicine

130

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Tulsi, also known as holy basil, is indigenous to the Indian continent and highly revered for its medicinal uses within the Ayurvedic and Siddha medical systems. Many in vitro, animal and human studies attest to tulsi having multiple therapeutic actions including adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, and immunomodulatory effects, yet to date there are no systematic reviews of human research on tulsi's clinical efficacy and safety. We conducted a comprehensive literature review of human studies that reported on a clinical outcome after ingestion of tulsi. We searched for studies published in books, theses, conference proceedings, and electronic databases including Cochrane Library, Google Scholar, Embase, Medline, PubMed, Science Direct, and Indian Medical databases. A total of 24 studies were identified that reported therapeutic effects on metabolic disorders, cardiovascular disease, immunity, and neurocognition. All studies reported favourable clinical outcomes with no studies reporting any significant adverse events. The reviewed studies reinforce traditional uses and suggest tulsi is an effective treatment for lifestyle-related chronic diseases including diabetes, metabolic syndrome, and psychological stress. Further studies are required to explore mechanisms of action, clarify the dosage and dose form, and determine the populations most likely to benefit from tulsi's therapeutic effects.

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Anticonvulsant and anxiolytic evaluation of leaf extracts ofOcimum gratissimum, a culinary herb

Cited by 49 publications

References 22 publications

Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters

Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters

Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review

The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature

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