Anticoccidial Activity of Lasalocid (X-537A) in Chicks

Mitrovic, M.; Schildknecht, E. G.

doi:10.3382/ps.0531448

Cited by 46 publications

(13 citation statements)

References 3 publications

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“…A lasalocida, quando utilizada nas doses de 75-125ppm nas rações de frangos, é eficaz em infecções causadas por espécies do gênero Eimeria (Mitrovic & Schildknecht 1974), reduz a população de E. bovis e E. zuernii em bovinos infectados experimentalmente (Stromberg et al 1982) e, quando misturada ao leite, protege bezerros contra infecção por es-sas mesmas espécies de Eimeria (Erasmus et al 1999). Em coelhos, concentrações de 90 e 125ppm, fornecidas aos animais naturalmente infectados durante 5 semanas, resultam em baixo índice de produção.…”

Section: Utilização E Dosagensunclassified

Intoxicação por antibióticos ionóforos em animais

2009

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RESUMO.-O uso terapêutico de antibióticos ionóforos em medicina veterinária difundiu-se muito nos últimos anos, com conseqüente aumento no risco de intoxicação em animais. Antibióticos ionóforos são usados como coccidiostáticos e como aditivo em alimentos para animais, com o propósito de estimular o desenvolvimento e o ganho de peso. Os ionóforos mais utilizados na alimentação de animais são a monensina, lasalocida, nasarina e salinomicina. Há uma grande variação na susceptibilidade dos efeitos tóxicos dos ionóforos de acordo com a espécie animal. A intoxicação pode ocorrer quando dosagens elevadas de ionóforos são adicionadas aos alimentos, ou quando ionóforos são incluídos inadvertidamente ou acidentalmente em dosagens não corretas para determinada espécie animal. Casos de intoxicação têm sido descritos em bovinos, ovinos, suínos, eqüinos, cães e aves. Para os eqüi-nos os ionóforos são extremamente tóxicos. São considerados seguros quando usados nas espécies-alvo, dentro das dosagens recomendadas pelo fabricante. The therapeutic use of ionophores in veterinary medicine has grown in the last years, with resultant increase in the risk of poisoning in animals. Ionophores are used as food additives as coccidiostacts in several animal species and growth promoter and bloat prevention in ruminants. The most often used ionophores are monensin, lasalocid, narasin and salinomycin. There is a great variation in the susceptibility to the toxic effect of ionophores in different animal species. Poisoning can occur when the dosage is too high or when not correct doses for a certain animal species are given. Cases of poisoning have been described in sheep, swine, horses, dogs and poultry. For horses ionophores are extremely toxic. The use of ionophores is only safe when used accordingly to the instructions of the manufacturer and especially for each animal species. In this paper the most important data regarding clinical-pathological and pathogenic aspects, and also the conditions in which the poisoning may occur are critically reviewed.

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Section: Utilização E Dosagensunclassified

Intoxicação por antibióticos ionóforos em animais

2009

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“…Lasalocid's anticoccidial efficacy for chickens against all pathogenic species of Eimeria has been reported by several workers (Mitrovic and Schildknecht, 1973Edgar and Flanagan, 1974;Taylor etal, 1974;Reid et al, 1975). Compatibility data for lasalocid fed in combination with penicillin, zinc bacitracin, lincomycin, bambermycin or roxarsone had been presented by who found increased growth and improved feed conversion elicited by the growth promotant additives in two-week trials.…”

Section: Introductionmentioning

confidence: 82%

Effect of Diet on the Performance of Broiler Chickens Fed Lasalocid in Combination with Growth Promotants

Marusich¹,

Ogrinz²,

Camerlengo³

et al. 1977

Poultry Science

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Lasalocid, a highly effective anticoccidial, was fed with several broiler growth promotants in three 8-week battery trials. A corn-soy ration was used in the first two trials and a rye-soy ration in the third. Birds were weighed at 1, 28, and 56 days, with feed intake recorded continuously and pigmentation measured at eight weeks.In the first trial, 0.0075% lasalocid was fed alone and in combination with 0.0025 or 0.005% roxarsone, 0.0055% zinc bacitracin or 0.00044% lincomycin. Improved growth and feed conversion were seen with all combinations and increased pigmentation with roxarsone. In the second study, 0.0125% lasalocid and 0.005% roxarsone were fed alone and combined. Roxarsone alone and in combination with lasalocid increased pigmentation. In the third trial, with the rye-soy ration, lasalocid was fed at 0.0075 or 0.0125% alone and in combination with 0.005% roxarsone and/or 0.0055% zinc bacitracin. Increased weight gain, improved feed conversion, or increased pigmentation were seen with the various combinations and the magnitude of response, especially growth, was far greater than that obtained with the corn-soy ration.Combinations of lasalocid and the broiler growth promotants, at the concentrations tested, were compatible and safe.

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“…Lasalocid acid (Scheme 1) is well known carboxylic polyether ionophore isolated from Streptomyces lasaliensis. Its sodium salt (Bovatec TM , Avatec TM ) is one of the most commonly used veterinary antibiotics since it is an widely spread anticoccidial agent [4][5][6][7]. The mechanism of lasalocid activity is clearly attributed to its ionophoric properties.…”

Section: Introductionmentioning

confidence: 99%