Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues

Pecnard, Shannon; Hamzé, Abdallah; Bignon, Jérôme; Prost, Bastien; Deroussent, Alain; Gallego‐Yerga, Laura; Peláez, Rafael; Paik, Ji Yeon; Diederich, Marc; Alami, Mouâd; Provot, Olivier

doi:10.1016/j.ejmech.2021.113656

Cited by 25 publications

(9 citation statements)

References 46 publications

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“…Its derivatives possess a broad spectrum of biological activities, including antimicrobial [ 12 , 13 , 14 , 15 ], antitubercular [ 16 , 17 , 18 ], anti-tumor [ 19 , 20 , 21 , 22 , 23 ], antiviral [ 17 , 24 , 25 ], antioxidant [ 12 , 21 ], anti-inflammatory [ 17 , 25 , 26 , 27 ], antifungal [ 28 , 29 , 30 ], antimalarial [ 17 , 31 ], antidepressants [ 17 ], antidiabetic [ 25 , 26 , 32 ], аnti-Alzheimer’s [ 26 , 33 ], and antibacterial [ 26 , 34 ] properties.…”

Section: Introductionmentioning

confidence: 99%

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives

2023

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Indoles and hydantoins are important heterocycles scaffolds which present in numerous bioactive compounds which possess various biological activities. Moreover, they are essential building blocks in organic synthesis, particularly for the preparation of important hybrid molecules. The series of hybrid compounds containing indoles and imidazolidin-2-one moiety with direct С─С bond were synthesized using an amidoalkylation one-pot reaction. All compounds were investigated as a growth regulator for germination, growth and development of wheat seeds (Triticum aestivum L). Their effect on drought resistance at very low concentrations (4 × 10−5 М) was evaluated. The study highlighted identified the leading compounds, 3a and 3e, with higher growth-regulating activity than the indole-auxin analogues.

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Section: Introductionmentioning

confidence: 99%

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives

2023

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“…Synthesis, and anticancer activity of a novel naturally occurring azepinoindole alkaloids analogs such as [1,2,4,5]tetrazepino[6,7-b] indole (35) derivatives were reported by Farghaly et al [75] The anticancer activity of all the derivatives was tested against two carcinoma cell lines (A-549&HepG2) in comparison with the well-known anticancer standard drug cisplatin. Recently, Pecnard and co-workers [76] studied an array of novel ligands comparative to Combretastatin A-4 andiso-Combretastatin A-4, which were prepared and tested for their anticancer property. Amongst, all the compounds, (1-ethyl-5-(methyl(2-methylquinazolin-4-yl)amino)-1H-indol-2-yl)methanol (36) showed remarkable cytotoxicity (IC 50 < 1 nM) against 9 human cancer cell lines.…”

Section: Anticancer Activitymentioning

confidence: 99%

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

Mathada¹,

Yernale

Basha³

2023

ChemistrySelect

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Heterocycles are a privileged motif that appears as a momentous objective in medicinal chemistry. An important class of compounds for drug discovery and design is indole and its derivatives, which have been examined for a variety of biological activities. Therefore, it is noteworthy in the modern progress of synthetic, medicinal chemistry; the last decade has been onlooker with a multitude of reports on several indole derivatives corroborating these chemical entities to be a renowned target for the discovery of new drugs. The current study includes brief natural sources of indole, and a new range of commercially available indole‐based drugs. Additionally, this review discusses the numerous facets of the structure‐activity relationship study (SARs) and provides information about the varied pharmacological effects of indole derivatives. The literature data presented for the anti‐pharmacological agents herein covers largely from the year 2015 to mid of 2022.

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“…These compounds have demonstrated potent antiproliferative properties on human colon cancer cells. [6,[8][9] This work discusses recent developments in the synthesis of aza-heterocyclic compounds using NTHs as key reagents. The process involves the formation of an olefin intermediate 3 (Scheme 1), which is obtained by a palladium-catalyzed carbene coupling reaction between NTH 1 and ortho-nitrobenzene derivatives 2.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Aza‐Heterocyclic Compounds with N‐Tosylhydrazones: Formation of Bi‐Indoles via Reductive Molybdenum Catalysis

Liu,

Provot,

Franco

et al. 2023

Adv Synth Catal

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In this study, we present a methodology for synthesizing aza‐heterocyclic compounds using N‐tosylhydrazones as key reagents. Our primary objective was to obtain six or seven‐membered ring heterocycles; however, we unexpectedly observed the formation of bi‐indole compounds in high yields. Furthermore, our synthetic pathway enables modifications at the C3 or C2 position of the indole, leading to the formation of the respective 3′‐phenyl‐2′‐biindole or carbazole derivatives.

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Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues

Cited by 25 publications

References 46 publications

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

Synthesis of Aza‐Heterocyclic Compounds with N‐Tosylhydrazones: Formation of Bi‐Indoles via Reductive Molybdenum Catalysis

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