The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

Abstract

Heterocycles are a privileged motif that appears as a momentous objective in medicinal chemistry. An important class of compounds for drug discovery and design is indole and its derivatives, which have been examined for a variety of biological activities. Therefore, it is noteworthy in the modern progress of synthetic, medicinal chemistry; the last decade has been onlooker with a multitude of reports on several indole derivatives corroborating these chemical entities to be a renowned target for the discovery of new drugs. The current study includes brief natural sources of indole, and a new range of commercially available indole‐based drugs. Additionally, this review discusses the numerous facets of the structure‐activity relationship study (SARs) and provides information about the varied pharmacological effects of indole derivatives. The literature data presented for the anti‐pharmacological agents herein covers largely from the year 2015 to mid of 2022.

Transition‐Metal Free Arylation of Therapeutically Important Heterocycles

“…However, this method provided activities, including anti-inflammatory, antiviral, and anti-histaminic properties. [26] For example, serotonin and tryptophan are just a couple of bioactive natural products produced in living organisms (Figure 3). Likewise, several drugs such as indomethacin, fluvastatin etc.…”

Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents: in silico study and biological screening

“…Various methods for crafting spiroxindole derivatives have been documented. [41][42][43][44] Most of these synthetic routes can be categorized based on the following key reactions: (1) Mannich/Pictet-Spengler; 45,46 (2) 1,3-dipolar cycloaddition; 47,48 (3) Morita-Baylis-Hillman, 49,50 intermolecular alkylation; 51,52 (4) electrocyclization; 53 (5) sigmatropic rearrangement reactions. 54,55 For instance, Hongyu Guo and coworkers reported the synthesis of spirooxindolepyrazolines and pyrazolones via P(NMe 2 ) 3 -mediated substratecontrolled annulations of azoalkenes with α-dicarbonyl compounds.…”

Antimicrobial Activity of N‐Substituted Derivatives of 5‐Chloro‐2,3‐ Diphenyl Indole

“…Several recent publications have reported the biological activity of organic molecules with an indole moiety in their chemical compositions [1–8] . Indoles are considered to play a significant role in drug discovery in almost all evaluations because of their extensive and varied biological actions.…”