Anticancer potential of ZnO nanoparticle-ferulic acid conjugate on Huh-7 and HepG2 cells and diethyl nitrosamine induced hepatocellular cancer on Wistar albino rat

Ezhuthupurakkal, Preedia Babu; Subastri, Ariraman; Arumugam, Suyavaran; Subramaniyan, Nithyananthan; Muthuvel, Suresh Kumar; Premkumar, Kumpati; Rajamani, Bharathidasan; Thirunavukkarasu, Chinnasamy

doi:10.1016/j.nano.2017.11.003

Cited by 37 publications

(16 citation statements)

References 43 publications

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“…It has limited applicability owing to its poor solubility;, FA is therefore, encapsulated into cyclodextrin nano sponges improved its solubility and in vitro cytotoxicity thus, representing a suitable delivery system with enhanced antiproliferative activity in MCF-7 and 4T1 breast cancer cell lines when compared with free FA [78]. Actually, the conjugation of nanoparticle with phytochemicals may represent a new approach in combinatorial chemotherapy as was demonstrated by the use of ZnO nanoparticle-FA conjugate in Huh-7, hepG2 cells and diethylnitrosamine-induced hepatocellular cancer on Wistar albino rat model [80]. Moreover, polyFE (chemically modified FE) loading doxorubicin nanoparticles maintained effective delivery of the drug in the acidic tumor microenvironment in vitro and reduced toxicity of free doxorubicin in vivo [81].…”

Section: Ferulic Acidmentioning

confidence: 99%

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Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

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Globally, cancer is the second leading cause of death. Different conventional approaches to treat cancer include chemotherapy or radiotherapy. However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promoting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis). Phenolic acids are a subclass of plant phenolics, furtherly divided into benzoic and cinnamic acids, that are associated with potent anticancer abilities in various in vitro and in vivo studies. Moreover, the therapeutic activities of phenolic acids are reinforced by their role as epigenetic regulators as well as supporters of adverse events or resistance associated with conventional anticancer therapy. Encapsulation of phyto-substances into nanocarrier systems is a challenging aspect concerning the efficiency of natural substances used in cancer treatment. A summary of phenolic acids and their effectiveness as well as phenolic-associated advances in cancer treatment will be discussed in this review.

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Section: Ferulic Acidmentioning

confidence: 99%

“…As well as in Fe 3 O 4 -PEG-GA [46] and PLGA-CS-PEG used to encapsulate GA [47]. Encapsulation of FE into cyclodextrin nanosponges led to improved solubility and cytotoxicity [80]. Eventually, the potential of natural compounds in association with benefit of nanocomposites need to be further studied [26].…”

Section: Conclusion and Future Aspectsmentioning

confidence: 99%

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

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“…In vitro: AML-12, LX2 cells and primary pepatocytes ↓ lipid peroxidation [75] In vitro: N1-S1 hepatoma cells ↑ apoptosis In animal model: ↓ liver nodules ↓ cirrhosis ↓ inflammatory markers [78] 3 evaluated in hepatic stellate cells (HSCs), it was reported that treatment with caffeine increased apoptosis, increased the expression of intracellular F-actin and cAMP, and inhibited the expression of procollagen type Ic and α-SMA; which suggests that caffeine can attenuate the progression of liver fibrosis by inhibiting HSCs adhesion and activation. [68] The authors confirmed these results in a rat model where caffeine decreased peri-portal inflammation, levels of inflammatory cells and fibrosis.…”

Section: Hepg2 Cellsmentioning

confidence: 99%

Chemopreventive effect of coffee against colorectal cancer and hepatocellular carcinoma

Moreno-Ceballos

Arroyave

Cortés-Mancera

et al. 2019

International Journal of Food Properties

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Cancer is a complex and evolving disease that is the leading cause of death in the twenty-first century, and colorectal and liver cancers specifically are in the top 10 cancer types in terms of incidence and mortality; therefore, there has been a shift towards researching prevention strategies, amongst which chemoprevention is key. Coffee is a natural product that has recently gained importance in this area due to its chemopreventive potential and its high level of consumption worldwide. In this review, recent epidemiological and experimental evidence of the chemopreventive effect of coffee against these two types of cancer are presented, and the role of the different compounds present in coffee in cell proliferation, apoptosis and response to oxidative stress are discussed.

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“…With conspicuous antimicrobial properties, Zinc oxide nanoparticles (nZnO) have been widely used in the medical field, especially its toxicity toward tumor cells. 4,5 For example, nZnO could result in decrease of cellular viability, loss of membrane integrity and damage to DNA structure. 6 Nevertheless, all the above mechanisms mainly focus on higher concentration exposure of nZnO that induce distinct injury and cytotoxicity in tumor cells.…”

Section: Introductionmentioning

confidence: 99%

<p>Anticancer Effects of Zinc Oxide Nanoparticles Through Altering the Methylation Status of Histone on Bladder Cancer Cells</p>

Zhang

Liu

et al. 2020

IJN

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Purpose: Zinc oxide nanoparticles (nZnO) have been widely used in the medicine field. Numerous mechanistic studies for nZnO's anticancer effects are merely performed under high concentration exposure. However, possible anticancer mechanisms of epigenetic dysregulation induced by low doses of nZnO are unclear. Methods: nZnO were characterized and bladder cancer T24 cells were treated with nZnO for 48 hrs at different exposure concentrations. Cell cycle, apoptosis, cell migration and invasion were determined. We performed qRT-PCR, Western blot and chromatin immunoprecipitation to detect the mRNA and protein levels of signaling pathway cascades for histone modification. Results: In this study, we investigated the potential anticancer effects and mechanisms of nZnO on histone modifications in bladder cancer T24 cells upon low-dose exposure. Our findings showed that low concentrations of nZnO resulted in cell cycle arrest at S phase, facilitated cellular late apoptosis, repressed cell invasion and migration after 48 hrs exposure. These anticancer effects could be attributed to increased RUNX3 levels resulting from reduced H3K27me 3 occupancy on the RUNX3 promoter, as well as decreased contents of histone methyltransferase EZH2 and the trimethylation of histone H3K27. Our findings reveal that nZnO are able to enter into the cytoplasm and nucleus of T24 cells. Additionally, both particles and ions from nZnO may jointly contribute to the alteration of histone methylation. Moreover, sublethal nZnO-conducted anticancer effects and epigenetic mechanisms were not associated with oxidative stress or DNA damage. Conclusion: We reveal a novel epigenetic mechanism for anticancer effects of nZnO in bladder cancer cells under low-dose exposure. This study will provide experimental basis for the toxicology and cancer therapy of nanomaterials.

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Anticancer potential of ZnO nanoparticle-ferulic acid conjugate on Huh-7 and HepG2 cells and diethyl nitrosamine induced hepatocellular cancer on Wistar albino rat

Cited by 37 publications

References 43 publications

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Chemopreventive effect of coffee against colorectal cancer and hepatocellular carcinoma

<p>Anticancer Effects of Zinc Oxide Nanoparticles Through Altering the Methylation Status of Histone on Bladder Cancer Cells</p>

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