Chemopreventive effect of coffee against colorectal cancer and hepatocellular carcinoma

Moreno-Ceballos, Manuel; Arroyave, Johanna C.; Cortés-Mancera, Fabián; Röthlisberger, Sarah

doi:10.1080/10942912.2019.1593193

Cited by 13 publications

(7 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, experimental evidence that the protective effect of coffee components on NAFLD is related to antioxidant effects is still unclear [180,183]. It has been reported that CGA protects against palmitate-induced ER stress and apoptosis in vitro [178,184]. Moreover, based on experimental models of high-fat-/high-carbohydrate-induced NALFD, it has been reported that CGA exhibits hepatoprotective effects, including improvement of metabolic function, reducing inflammation, and improving liver histology [185].…”

Section: Coffee Components: Caffeine and Coffee Polyphenolsmentioning

confidence: 99%

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

et al. 2021

View full text Add to dashboard Cite

Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of lipid metabolism is closely related to alterations of the oxidant/antioxidant balance, which affect metabolism-related organelles, leading to cellular lipotoxicity, lipid peroxidation, chronic endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Increased OxS also triggers hepatocytes stress pathways, leading to inflammation and fibrogenesis, contributing to the progression of non-alcoholic steatohepatitis (NASH). The antioxidant response, regulated by the Nrf2/ARE pathway, is a key component in this process and counteracts oxidative stress-induced damage, contributing to the restoration of normal lipid metabolism. Therefore, modulation of the antioxidant response emerges as an interesting target to prevent NAFLD development and progression. This review highlights the link between disturbed lipid metabolism and oxidative stress in the context of NAFLD. In addition, emerging potential therapies based on antioxidant effects and their likely molecular targets are discussed.

show abstract

Section: Coffee Components: Caffeine and Coffee Polyphenolsmentioning

confidence: 99%

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[52] Sustainability Practices of small farmers for climate change mitigation. [53] Health Coffee's role against the apparition of colorectal and liver cancer. [54] Quality Storage of coffee crop (hermetic bags) for preserving the quality.…”

Section: Referencementioning

confidence: 99%

Roadmapping as a Driver for Knowledge Creation: A Proposal for Improving Sustainable Practices in the Coffee Supply Chain from Chiapas, Mexico, Using Emerging Technologies

Contreras-Medina

Núñez

et al. 2020

Sustainability

View full text Add to dashboard Cite

Technologies are essential for productive sectors to increase competitiveness and improve sustainable development. However, the technology benefits present a great delay in adoption in agricultural sectors, due to discrepancies between scientific research and local needs. This article presents a study for improving sustainability practices in the coffee supply chain, using emerging technologies, of two localities in the Frailesca region from Chiapas, Mexico, based on the current situation, expectations and actions expressed by 165 coffee producers and 12 representatives of two coffee producers’ organizations. Based on Mentzer theoretical support, the technology roadmaps, knowledge management and digital compass were used to draw coffee supply chain processes to identify concrete actions and explore technologies. The results show that the technological route must be focused on renewing and improving coffee quality, getting quality certifications and access to specialized markets. Digital quality management and advanced statistical process control seem to be the appropriate emerging technologies for enhancing the acquisition of resistant varieties, proper pest management, improvement in the collection of coffee beans, the right time and way to plant a coffee plant, soil analysis and for the management of weeds and water conservation and harvesting as sustainable practices in this region. In addition, statistical correlation showed that digital technologies can be better adopted, on average, by producers with 4–6 family members, aged between 40–44 years and without additional crops. The findings propose sustainable practices linked with emerging technologies, based on a technology roadmap and knowledge management methodologies for this region.

show abstract

“…Although different studies have reported several biological properties of CGA [ 43 , 44 ], there still needs to be clear evidence about the role of this natural compound in CRC. In the present study, we showed that CGA induced ROS production and mitochondrial hyperpolarization, which results in the DNA fragmentation and reduced cell viability of colon cancer cells, which harbors alterations in the Wnt/β-catenin pathway.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Study on the Impact of Chlorogenic Acid in Colorectal Cancer Cells: Proliferation, Apoptosis, and Interaction with β-Catenin and LRP6

et al. 2023

View full text Add to dashboard Cite

Colorectal cancer mortality rate and highly altered proteins from the Wnt/β-catenin pathway increase the scientific community’s interest in finding alternatives for prevention and treatment. This study aims to determine the biological effect of chlorogenic acid (CGA) on two colorectal cancer cell lines, HT-29 and SW480, and its interactions with β-catenin and LRP6 to elucidate a possible modulatory mechanism on the Wnt/β-catenin pathway. These effects were determined by propidium iodide and DiOC6 for mitochondrial membrane permeability, MitoTracker Red for mitochondrial ROS production, DNA content for cell distribution on cell cycle phases, and molecular docking for protein–ligand interactions and binding affinity. Here, it was found that CGA at 2000 µM significantly affects cell viability and causes DNA fragmentation in SW480 cells rather than in HT-29 cells, but in both cell lines, it induces ROS production. Additionally, CGA has similar affinity and interactions for LRP6 as niclosamide but has a higher affinity for both β-catenin sites than C2 and iCRT14. These results suggest a possible modulatory role of CGA over the Wnt/β-catenin pathway in colorectal cancer.

show abstract

Chemopreventive effect of coffee against colorectal cancer and hepatocellular carcinoma

Cited by 13 publications

References 78 publications

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

Roadmapping as a Driver for Knowledge Creation: A Proposal for Improving Sustainable Practices in the Coffee Supply Chain from Chiapas, Mexico, Using Emerging Technologies

In Vitro and In Silico Study on the Impact of Chlorogenic Acid in Colorectal Cancer Cells: Proliferation, Apoptosis, and Interaction with β-Catenin and LRP6

Contact Info

Product

Resources

About