Anticancer peptide: Physicochemical property, functional aspect and trend in clinical application (Review)

Chiangjong, Wararat; Chutipongtanate, Somchai; Hongeng, Suradej

doi:10.3892/ijo.2020.5099

Cited by 203 publications

(169 citation statements)

References 212 publications

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“…Therefore, from the point of structure–activity relationship (SAR) studies, it may be estimated that these naturally occurring cyclopeptides insert their toxicity on cancer cells by a hydrophobic/hydrophilic characteristic balanced equal to a 4/1 ratio. This estimate is in accordance with a study that reports higher hydrophobic peptides infuse better into the cancer cells through the nonpolar part of the cell membrane, which results in cell disruption and necrosis ( 82 , 83 ). Moreover, the presence of proline as well as glycine in the peptides is important for interaction with the cancer cell membrane ( 84 ).…”

Section: Resultssupporting

confidence: 93%

“…Phenylalanine residue can also increase the affinity of the peptides for interaction with the membrane of cancer cells ( 85 ). On the other hand, tyrosine residue as a polar amino acid may raise the toxicity of the peptides toward cancer cells ( 83 , 86 ). In addition, the cyclic form of the peptides with fixed conformational structure and less occupying space can cause peptides to face less of a physical barrier to enter the cells ( 87 ).…”

Section: Resultsmentioning

confidence: 99%

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Cancer Treatment by Caryophyllaceae-Type Cyclopeptides

et al. 2021

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Cancer is one of the leading diseases, which, in the most cases, ends with death and, thus, continues to be a major concern in human beings worldwide. The conventional anticancer agents used in the clinic often face resistance among many cancer diseases. Moreover, heavy financial costs preclude patients from continuing treatment. Bioactive peptides, active in several diverse areas against man’s health problems, such as infection, pain, hypertension, and so on, show the potential to be effective in cancer treatment and may offer promise as better candidates for combating cancer. Cyclopeptides, of natural or synthetic origin, have several advantages over other drug molecules with low toxicity and low immunogenicity, and they are easily amenable to several changes in their sequences. Given their many demanded homologues, they have created new hope of discovering better compounds with desired properties in the field of challenging cancer diseases. Caryophyllaceae-type cyclopeptides show several biological activities, including cancer cytotoxicity. These cyclopeptides have been discovered in several plant families but mainly are from the Caryophyllaceae family. In this review, a summary of biological activities found for these cyclopeptides is given; the focus is on the anticancer findings of these peptides. Among these cyclopeptides, information about Dianthins (including Longicalycinin A), isolated from different species of Caryophyllaceae, as well as their synthetic analogues is detailed. Finally, by comparing their structures and cytotoxic activities, finding the common figures of these kinds of cyclopeptides as well as their possible future place in the clinic for cancer treatment is put forward.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Cancer Treatment by Caryophyllaceae-Type Cyclopeptides

et al. 2021

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“…In addition, imaging tracers have to be biocompatible, stable and non-toxic. In order to increase the specific accumulation to the targeted tissue, imaging probes are generally couple to molecules like antibodies, small ligands or peptides [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. In this context, specificity of monoclonal antibodies (mAbs) is considered an important feature and, indeed, they represent a widely used tool in several molecular imaging protocols.…”

Section: Nanobodies: Characteristic and Structurementioning

confidence: 99%

Nanobodies as Versatile Tool for Multiscale Imaging Modalities

et al. 2020

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Molecular imaging is constantly growing in different areas of preclinical biomedical research. Several imaging methods have been developed and are continuously updated for both in vivo and in vitro applications, in order to increase the information about the structure, localization and function of molecules involved in physiology and disease. Along with these progresses, there is a continuous need for improving labeling strategies. In the last decades, the single domain antigen-binding fragments nanobodies (Nbs) emerged as important molecular imaging probes. Indeed, their small size (~15 kDa), high stability, affinity and modularity represent desirable features for imaging applications, providing higher tissue penetration, rapid targeting, increased spatial resolution and fast clearance. Accordingly, several Nb-based probes have been generated and applied to a variety of imaging modalities, ranging from in vivo and in vitro preclinical imaging to super-resolution microscopy. In this review, we will provide an overview of the state-of-the-art regarding the use of Nbs in several imaging modalities, underlining their extreme versatility and their enormous potential in targeting molecules and cells of interest in both preclinical and clinical studies.

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“…Anticancer peptides (ACPs) are small peptides exerting selective and toxic properties toward cancer cells. Owing to its inherent high penetration, high selectivity and ease of modification, synthetic peptide-based drugs and vaccines 1 – 3 represents a promising class of therapeutic agents. Designed ACPs can improve affinity, selectivity and stability for enhancing cancer cell elimination.…”

Section: Introductionmentioning

confidence: 99%

Improved prediction and characterization of anticancer activities of peptides using a novel flexible scoring card method

Charoenkwan

Chiangjong

Lee

et al. 2021

Sci Rep

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As anticancer peptides (ACPs) have attracted great interest for cancer treatment, several approaches based on machine learning have been proposed for ACP identification. Although existing methods have afforded high prediction accuracies, however such models are using a large number of descriptors together with complex ensemble approaches that consequently leads to low interpretability and thus poses a challenge for biologists and biochemists. Therefore, it is desirable to develop a simple, interpretable and efficient predictor for accurate ACP identification as well as providing the means for the rational design of new anticancer peptides with promising potential for clinical application. Herein, we propose a novel flexible scoring card method (FSCM) making use of propensity scores of local and global sequential information for the development of a sequence-based ACP predictor (named iACP-FSCM) for improving the prediction accuracy and model interpretability. To the best of our knowledge, iACP-FSCM represents the first sequence-based ACP predictor for rationalizing an in-depth understanding into the molecular basis for the enhancement of anticancer activities of peptides via the use of FSCM-derived propensity scores. The independent testing results showed that the iACP-FSCM provided accuracies of 0.825 and 0.910 as evaluated on the main and alternative datasets, respectively. Results from comparative benchmarking demonstrated that iACP-FSCM could outperform seven other existing ACP predictors with marked improvements of 7% and 17% for accuracy and MCC, respectively, on the main dataset. Furthermore, the iACP-FSCM (0.910) achieved very comparable results to that of the state-of-the-art ensemble model AntiCP2.0 (0.920) as evaluated on the alternative dataset. Comparative results demonstrated that iACP-FSCM was the most suitable choice for ACP identification and characterization considering its simplicity, interpretability and generalizability. It is highly anticipated that the iACP-FSCM may be a robust tool for the rapid screening and identification of promising ACPs for clinical use.

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Anticancer peptide: Physicochemical property, functional aspect and trend in clinical application (Review)

Cited by 203 publications

References 212 publications

Cancer Treatment by Caryophyllaceae-Type Cyclopeptides

Cancer Treatment by Caryophyllaceae-Type Cyclopeptides

Nanobodies as Versatile Tool for Multiscale Imaging Modalities

Improved prediction and characterization of anticancer activities of peptides using a novel flexible scoring card method

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