Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles

Chen, Yan; Wan, Ying; Wang, Yi; Zhang, Haijun; Jiao, Zhijun

doi:10.2147/ijn.s25460

Cited by 38 publications

(13 citation statements)

References 20 publications

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“…The introduction of nanosized photo- and sonosensitizers to the medicine gave rise to develop new therapeutic strategies, photodynamic therapy (PDT) [113] and sonodynamic therapy (SDT) [114], respectively. Designing of new ways of NM-based targeted drug delivery into cancer cells (targeted therapy) lowered side effects inflicted by many marketed drugs, such as doxorubicin and daunorubicin [115–117]. Among the scientists, great hopes to fight cancer more effectively are attributed to the application of NPs of metal oxides (e.g., TiO 2 , ZnO) in PDT [113, 118, 119], a treatment strategy presenting an alternative to chemo- and radiotherapy.…”

Section: Reviewmentioning

confidence: 99%

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e.g., in nanomedicine. NMs and NPs are perceived as very promising in cancer therapy since they can perform as drug carriers, as well as photo- or sonosensitizers (compounds that generate the formation of reactive oxygen species as a result of either electromagnetic radiation excitation with an adequate wavelength or ultrasound activation, respectively). Consequently, two new treatment modalities, the photodynamic therapy (PDT) and the sonodynamic therapy (SDT) have been created. The attachment of ligands or antibodies to NMs or to NPs improve their selective distribution into the targeted organ or cell; hence, the therapy effectiveness can be improved. An important advantage of the targeted tumor treatment is lowering the cyto- and genotoxicity of active substance towards healthy cells. Therefore, both PDT and SDT constitute a valuable alternative to chemo- or radiotherapy. The vital role in cancer eradication is attributed to two inorganic sensitizers in their nanosized scale: titanium dioxide and zinc oxide.

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Section: Reviewmentioning

confidence: 99%

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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“…Surgery, even though conventionally considered minor, has been associated with the indirect induction of a pro-inflammatory profile [38]. Chemotherapy, such as Dox, the first line treatment for hematological malignancies and solid tumors due to broad spectrum of anticancer activity, is limited by its harmful side effects, especially its cardiotoxicity, which can lead to cardiomyopathy and congestive heart failure [39]. In addition, radiotherapy is associated with the development of pulmonary toxicity [1].…”

Section: Resultsmentioning

confidence: 99%

Targeted photo-chemo therapy of malignancy on the chest wall while cardiopulmonary avoidance based on Fe3O4@ZnO nanocomposites

et al. 2016

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Treatment of malignancies on the chest wall, like chest wall recurrence of tumor, advanced cutaneous neoplasm and lymphoma, is still a challenge due to the involvement of the critical structures of heart and lung by the conventional strategy. The aim of the current study was to investigate targeted photo-chemo therapy mediated by Fe3O4@ZnO nanocomposites for malignancy on the chest wall while cardiopulmonary avoidance. Fe3O4@ZnO/Dox nanocomposites, the synthesis of the core-shell Fe3O4@ZnO nanocomposites followed by loading doxorubicin (Dox), were prepared to act as multifunctional drug delivery system (DDS). The synergistic anticancer effects on tumor on the chest wall and protection performance of heart and lung were evaluated in vitro and in vivo using cell viability assay, apoptosis detection, histopathologic examination, and serum biochemistry tests. Our observations demonstrated that Fe3O4@ZnO/Dox nanocomposites, could play the role of magnetic drug targeting to deliver Dox into tumor tissues and cells to enhance its chemotherapeutic efficiency. Besides, with ultraviolet (UV) illumination, Fe3O4@ZnO showed the excellent property of photosensitizer, further attacking the cancer cells by photodynamic therapy (PDT). Thus, apoptosis was synergistically induced by the photo-chemo therapy, resulting in a distinct improvement in anticancer activity. Since UV has a limited penetration distance in tissue, causing PDT to fail in the critical structures of heart and lung, cardiopulmonary hurt could be avoided during the treatment. Therefore, targeted photo-chemo therapy mediated by Fe3O4@ZnO nanocomposites may have promise as a potent treatment option for superficial malignancies on the chest wall while cardiopulmonary avoidance.

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“…Till today, many carriers including nanomaterials [19][20][21][22][23][24][25][26][27][28][29], magnetic materials [30][31][32][33][34][35], and graphene carriers [36,37] are widely used for drug delivery, food preparation, and the immobilization of enzymes. Most of these carriers are metal particles [38][39][40][41][42], and some of them as are biological macromolecules [43][44][45][46][47]. Unfortunately, extra carrier leads to the dilution of activity of immobilized enzymes because of the introducing of a large portion of the non-catalytic mass.…”

Section: Introductionmentioning

confidence: 99%

Combined Cross-Linked Enzyme Aggregates as Biocatalysts

Wang

et al. 2018

Catalysts

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Enzymes are efficient biocatalysts providing an important tool in many industrial biocatalytic processes. Currently, the immobilized enzymes prepared by the cross-linked enzyme aggregates (CLEAs) have drawn much attention due to their simple preparation and high catalytic efficiency. Combined cross-linked enzyme aggregates (combi-CLEAs) including multiple enzymes have significant advantages for practical applications. In this review, the conditions or factors for the preparation of combi-CLEAs such as the proportion of enzymes, the type of cross-linker, and coupling temperature were discussed based on the reaction mechanism. The recent applications of combi-CLEAs were also reviewed.

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Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles

Cited by 38 publications

References 20 publications

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Targeted photo-chemo therapy of malignancy on the chest wall while cardiopulmonary avoidance based on Fe3O4@ZnO nanocomposites

Combined Cross-Linked Enzyme Aggregates as Biocatalysts

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