Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design

Łos, Marek; Burek, Christof; Stroh, Christopher; Benedyk, Konrad; Hug, Hubert; Maćkiewicz, Andrzej

doi:10.1016/s1359-6446(02)02563-1

Cited by 110 publications

(67 citation statements)

References 93 publications

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“…One of the goals in using an anticancer drug/extract is the induction of apoptosis in cancer cells 33 . Induction of apoptosis is one of several approaches applied during cancer therapy 34 . Apoptosis is characterized by morphological changes of the cells including membrane blebbing, cytoplasmic and chromatin condensation, formation of apoptotic bodies, DNA fragmentation, alteration in membrane symmetry, activation of a cascade of caspases and a loss in mitochondrial membrane potential 35,36 .…”

Section: Discussionmentioning

confidence: 99%

Antimutagenic and anticancer effects of Avicennia marina leaf extract on Salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells

Karami¹,

Majd²,

Mehrabian³

et al. 2012

ScienceAsia

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The present study evaluated the antimutagenic and anticancer activities of A. marina leaf extract. The antimutagenic activity of ethanol and water extracts of A. marina leaf (concentration 10 mg/plate for 48 h) was evaluated using the Salmonella typhimurium TA100 strain in the Ames test with (+S9) and without (−S9) metabolic activation, and its anticancer effect with concentrations of 200, 400, 450, 500, 600, and 800 µg/ml of ethanol extract for 24, 48, and 72 h on human leukaemic cell line HL-60 was assessed by MTT assay. The ethanol and water extracts of A. marina were revealed to have antimutagenic activity in the Salmonella mutation assay. The number of mutant colonies decreased in the presence of ethanol and water extract with (+S9) and without (−S9) metabolic activation. The ethanol extract showed a higher antimutagenic effect than the water extract, with an inhibition rate of 71% on the mutated bacterium. The MTT cell viability test showed an induction of cytotoxicity in HL-60 cells treated with the extract with IC50 values of 600, 400, and 280 µg/ml after 24, 48, and 72 h, respectively, in a concentration and time-dependent manner. Flow cytometric analysis confirmed the induction of apoptosis in the cells. Collectively, these results suggest that the Avicennia marina leaf extract contains bioactive compounds with antimutagenic and antileukaemic effects.

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Section: Discussionmentioning

confidence: 99%

Antimutagenic and anticancer effects of Avicennia marina leaf extract on Salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells

Karami¹,

Majd²,

Mehrabian³

et al. 2012

ScienceAsia

View full text Add to dashboard Cite

show abstract

“…The role of apoptosis in cancer therapy has been extensively studied (Ghavami et al 2009;Los 2009;Los et al 2003). However, finding suitable and reliable drugs for treatment of various cancers is still a challenge for the medical community.…”

Section: Potentiation Of Apoptosis In Cancer Therapymentioning

confidence: 99%

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

Chaabane

User

El-Gazzah

et al. 2012

Arch. Immunol. Ther. Exp.

252

149

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“…For it is known today that the membrane receptor Fas (CD95) in conjunction with Fas ligand (FasL), a protein produced by immune cells, in addition to inducing apoptosis plays an important role in regulating cell proliferation and tumor growth. Thus, a dysfunction of the Fas/FasL in tissue cells by delaying apoptosis, may promote proliferative disorders, while a lower apoptotic activity of this system in PMNs, may have some therapeutic potential antiviral or anticancer effect [18,59,60] .…”

Section: Attenuation Of the Inflammatory Response: Actions On Neutropmentioning

confidence: 99%

“…Increased survival of PMNs can cause great tissue damage by longer secretion of toxic metabolites [62], while a shorter life span can mitigate immune reactions [59,60].…”

Section: Attenuation Of the Inflammatory Response: Actions On Neutropmentioning

confidence: 99%

Os leucócitos e a resposta inflamatória na lesão de isquemia-reperfusão

Francischetti¹,

Moreno²,

Scholz³

et al. 2010

Rev Bras Cir Cardiovasc

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The events of ischemia-reperfusion injury trigger a systemic inflammatory response that can lead to cellular damage and even organ failure. Such effects are noted in the post-operative recovery, especially with the use of cardiopulmonary bypass. Nowadays, we know that leukocytes play an important role in this process. Therefore, this study addresses the role of leukocytes in the pathophysiology of ischemia-reperfusion injury and activation of inflammatory cascades through this process and seeks to help in understanding these mechanisms as well as bringing contributions on the therapeutic approaches that may mitigate them. This retrospective review was performed from scientific papers published over the past ten years, in Portuguese and English, indexed in international databases of Medline, SciELO and related classical texts. The descriptors investigated were: ischemiareperfusion, leukocytes, inflammatory response, cardiopulmonary bypass, adverse effects and apoptosis.Keywords: Cardiopulmonary bypass. Leukocytes. Ischemia. Reperfusion injury. ResumoOs eventos de isquemia-reperfusão desencadeiam uma resposta inflamatória sistêmica que pode levar a lesões celulares e até falência de órgãos. Tais repercussões são notadas no pós-operatório de cirurgias, em especial, com o uso de circulação extracorpórea. Sabe-se, atualmente, que os leucócitos exercem importante papel neste processo. Assim, este estudo aborda o papel dos leucócitos na fisiopatologia das lesões de isquemia-reperfusão e a ativação das cascatas inflamatórias por esse processo e procura auxiliar na compreensão destes mecanismos assim como trazer contribuições acerca das abordagens terapêuticas que possam atenuá-los. Esta revisão bibliográfica retrospectiva foi realizada a partir de documentos científicos publicados nos últimos dez anos, em português e inglês, indexados em bases de dados internacionais Medline e SciELO e de textos clássicos relacionados. Os descritores pesquisados foram: isquemia-reperfusão, leucócitos, resposta inflamatória, circulação extracorpórea, efeitos adversos e apoptose.Descritores: Circulação extracorpórea. Leucócitos. Isquemia. Traumatismo por reperfusão. FRANCISCHETTI, I ET AL -Leukocytes and the inflammatory response in ischemia-reperfusion injuryRev Bras Cir Cardiovasc 2010; 25(4): 575-584

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Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design

Cited by 110 publications

References 93 publications

Antimutagenic and anticancer effects of Avicennia marina leaf extract on Salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells

Antimutagenic and anticancer effects of Avicennia marina leaf extract on Salmonella typhimurium TA100 bacterium and human promyelocytic leukaemia HL-60 cells

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

Os leucócitos e a resposta inflamatória na lesão de isquemia-reperfusão

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