Anticancer activity of esculetin via-modulation of Bcl-2 and NF-κB expression in benzo[a]pyrene induced lung carcinogenesis in mice

The protective effect of esculetin against aluminium chloride‐induced reproductive toxicity in rats

“…However, this increase was not statistically significant compared with the control group. In the previous study, it was reported that ESC did not cause a significant change in NF-κB expression level compared with the control group (Anand et al, 2013). In our study, it was observed that there F I G U R E 6 Distribution of Caspase-3 and Bcl-2 immunoreactivity scores by groups.…”

“…In the study, the dose of ESC (50 mg/kg p.o.) (Anand et al, 2013) and the dose of AlCl 3 (34 mg/kg p.o.) (Yousef & Salama, 2009) were determined according to the literature.…”

Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review

“…In a mechanistic study, esculetin was identified as potential Wnt-β-catenin pathway inhibitor by disrupting the formation of the β-catenin-Tcf complex while binding directly with the Lys345, Asn387, Lys312, and Gly307 residues of β-catenin. In addition, esculetin effectively antagonized the formation of the β-catenin-Tcf complex, which could contribute to β-catenin-dependent activity and suppress colon carcinogenesis [ 33 ]. Another study investigated the anti-proliferative effects of esculetin on tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis primarily through upregulation of apoptotic related DR5 proteins and correlative immunocytochemistry.…”

Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague–Dawley rats

“…NF-κB is a main transcription factor which is involved in the production of various proinflammatory cytokines like TNF-α, IL-1β, IL-6, etc. [40][41][42].…”