Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague–Dawley rats

Mundhe, Nitin; Kumar, Parveen; Ahmed, Sahabuddin; Jamdade, Vinayak S; Mundhe, Sanjay; Lahkar, Mangala

doi:10.1016/j.intimp.2015.07.016

Cited by 26 publications

(12 citation statements)

References 46 publications

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“…Therefore, cisplatin-induced nephrotoxicity can be ameliorated by free radical scavengers [70], iron chelators [71], superoxide dismutase [48] and Vitamin E [72]. …”

Section: Discussionmentioning

confidence: 99%

Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats

et al. 2017

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BackgroundCisplatin (CP) is commonly used in the treatment of different types of cancer but nephrotoxicity has been a major limiting factor. Therefore, the present study aimed to study the possible protective effect of rutin against nephrotoxicity induced by cisplatin in rats.MethodsForty male Wistar albino rats were randomly divided into 4 groups. Rats of group 1 control group intraperitoneal (i.p.) received 2.5 ml/kg, group 2 CP group received single dose 5 mg/kg cisplatin i.p. group 3 rutin group orally received 30 mg/kg rutin group 4 (CP plus rutin) received CP and rutin as in group 2 and 3. Kidneys were harvested for histopathology and for the study the gene expression of c-Jun N-terminal kinases (JNK), Mitogen-activated protein kinase 4 (MKK4), MKK7, P38 mitogen-activated protein kinases (P38), tumor necrosis factors alpha (TNF-α), TNF Receptor-Associated Factor 2 (TRAF2), and interleukin-1 alpha (IL-1-α).ResultsThe cisplatin single dose administration to rats induced nephrotoxicity associated with a significant increase in blood urea nitrogen (BUN) and serum creatinine and significantly increase Malondialdehyde (MDA) in kidney tissues by 230 ± 5.5 nmol/g compared to control group. The animal treated with cisplatin showed a significant increase in the expression levels of the IL-1α (260%), TRFA2 (491%), P38 (410%), MKK4 (263%), MKK7 (412%), JNK (680%) and TNF-α (300%) genes compared to control group. Additionally, histopathological examination showed that cisplatin-induced interstitial congestion, focal mononuclear cell inflammatory, cell infiltrate, acute tubular injury with reactive atypia and apoptotic cells. Rutin administration attenuated cisplatin-induced alteration in gene expression and structural and functional changes in the kidney. Additionally, histopathological examination of kidney tissues confirmed gene expression data.ConclusionThe present study suggested that the anti-oxidant and anti-inflammatory effect of rutin may prevent CP-induced nephrotoxicity via decreasing the oxidative stress, inhibiting the interconnected ROS/JNK/TNF/P38 MAPK signaling pathways, and repairing the histopathological changes against cisplatin administration.

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“…Therefore, cisplatin-induced nephrotoxicity can be ameliorated by free radical scavengers [70], iron chelators [71], superoxide dismutase [48] and Vitamin E [72]. …”

Section: Discussionmentioning

confidence: 99%

Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats

et al. 2017

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“…Histopathology of the kidney and the mammary tumor was performed as described previously (Mundhe et al, 2015; Jamdade et al, 2015a). Briefly, for light microscopy, autopsy samples were taken from the kidney and the mammary tumor of rats from different groups and fixed in 10% formal saline for 24 h. The washing was made out with distilled water, then serial dilutions of alcohol (methyl, ethyl, and absolute ethyl) were used for drying up.…”

Section: Methodsmentioning

confidence: 99%

“…Cisplatin (CIS), a frequently employed broad-spectrum antineoplastic agent, remains to be a preferred treatment modality for various malignancies despite ototoxicity, peripheral neuropathy, and nephrotoxicity (Mundhe et al, 2015; Jamdade et al, 2015a). The complex spectrum of CIS nephrotoxicity includes DNA damage, tubular toxicity, and inflammation (Kumar et al, 2013c).…”

Section: Introductionmentioning

confidence: 99%

Curcumin Ameliorates Cisplatin-Induced Nephrotoxicity and Potentiates Its Anticancer Activity in SD Rats: Potential Role of Curcumin in Breast Cancer Chemotherapy

Kumar

Barua²,

Sulakhiya

et al. 2017

Front. Pharmacol.

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Breast malignant neoplastic disease is one of the most complex diseases, as it is a multifactorial disease in which virtually all the targets are instantly or indirectly inter-reliant on each other. Cisplatin (CIS), an inorganic antineoplastic agent is widely utilized in the treatment of various solid tumors including breast cancer. Despite everything, its clinical use is limited, due to ototoxicity, peripheral neuropathy, and nephrotoxicity. The present work was directed to assess the combined result of curcumin (CUR) and CIS in 7, 12-dimethyl benz[a]anthracene (DMBA) induced breast cancer in rats and the prevention of nephrotoxicity induced by the latter. CIS-induced nephrotoxicity was assessed by change in body weight, kidney weight, altered levels of BUN, creatinine, TNF-α, IL-6, IL-8, IL-10, and histopathology of the kidney. Anticancer activity was assessed by measurement of tumor weight, tumor volume, % tumor inhibition, levels of PPAR-γ, and BDNF in mammary tumors and histopathology of mammary tumors. CUR pre-treatment mitigated nephrotoxicity by reducing the inflammatory markers (TNF-α, IL-6, and IL-8; p < 0.001). Further, it reduced mammary cancer via increasing the expression of PPAR-γ (p < 0.001) and decreasing the expression of BDNF (p < 0.001) in mammary tumors. It also reduced tumor volume, further postulating that CUR might adjunct the anticancer activity of the CIS. To the best of our knowledge, this is the first report, which showed that CUR ameliorated CIS-induced nephrotoxicity and improved its anticancer activity in DMBA induced breast cancer in female Sprague-Dawley rats.

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“…Several herbal compounds including nordihydroguaiaretic acid, eriodictyol‐7‐O‐glucoside, and thymol ameliorated cisplatin‐induced renal injury, in vitro and in vivo (Hosseinimehr et al, ; Hu, Zhang, Wang, Lou, & Ren, ; Mundhe et al, ). Resveratrol, genistein, and epigallocatechin‐3‐gallate attenuated apoptosis of haematopoietic cells via reducing DNA damage (Alotaibi, Bhatnagar, Najafzadeh, Gupta, & Anderson, ; Olas & Wachowicz, ; Sonaa, Usha, & Ja In, ).…”

Section: Herbal Compounds With the Potential To Synergize With Antitumentioning

confidence: 99%

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Lin

Hsu

Tsai

et al. 2019

British J Pharmacology

258

175

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Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague–Dawley rats

Cited by 26 publications

References 46 publications

Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats

Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats

Curcumin Ameliorates Cisplatin-Induced Nephrotoxicity and Potentiates Its Anticancer Activity in SD Rats: Potential Role of Curcumin in Breast Cancer Chemotherapy

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

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