Antibradykinin Active Material in Aloe saponaria

Assessment of genetic diversity in Aloe germplasm accessions from India using RAPD and morphological markers

“…Acemannan, the major carbohydrate fraction in the gel demonstrates antineoplastic and antiviral effects (Mc Daniel et al, 1990). The gel also contains bradykininase, an anti-inflammatory, which prevents itching, and salicylic acid and other antiprostaglandin compounds that relieves inflammation (Yagi et al, 1982). Other important pharmacological activities of Aloe vera are anti diabetic (Rajasekaran et al, 2006), antiseptic (Capasso et al, 1998), anti-tumor (Winter et al, 1981) and wound and burn healing effect (Heggers et al, 1993).…”

In vitro antibradykinin activity of Aloe barbadensis gel

“…Fujita et al (1979) and Itto et al (1993) proved that it is a serine carboxypeptidase. On the other hand, Yagi et al (1982) reported antibradykinin activity of Aloe saponaria extract suggesting that several Aloe species show the antibradykinin effect. However, it is important to point out that in accordance with our previous studies (Vazquez et al, 1996), this antibradykinin effect may be associated with the inhibition of prostaglandin synthesis in the anti-inflammatory mechanism of Aloe barbadensis.…”

“…natalensis Berger and Aloe saponaria Haw.) have an anti-inflammatory effect related to the inhibition of bradykinin; the effect of Aloe arborescens on bradykinin has been associated to bradykininase and carboxypeptidase activities (Fujita et al, 1979), whereas an unspecific antibradykinin activity has been ascribed to Aloe saponaria (Yagi et al, 1982). Bradykinin participates directly as a chemical mediator in a variety of inflammatory diseases and produces pain through the stimulation of primary sensor neurons, and provokes the release of neuropeptides, such as substance P, neurokinin A, and calcitonin gene-related peptide (Geppetty, 1993;Averbeck and Reeh, 2001); it also stimulates prostaglandin production and accumulation in inflammatory cells as macrophages, as well as acting as inflammatory mediators, such as IL-I and tumor necrosis factor ␣ (TNF␣) (Dray and Perkins, 1993;Bogar et al, 1999).…”

Mechanism of antiinflammatory and antithermal burn action of CPase from Aloe arborescens Miller var. natalensis Berger in rats and mice

“…This enzyme was characterized as serine carboxypeptidase which also hydrolysed angiotensin I, a vasopressor in oitro (Fujita et ul., 1979;Yagi et a[., 1987). Antiinflammatory action of rat serum carboxypeptidase N was reported (Rybak et al, 1978), and bradykininase activity was also found in other species of Aloe (Yagi et al, 1982). We focused o n the antiinflammatory activity of Aloe CPase as one of the key factors involved in the pharmaceutical effectiveness of Aloe.…”