Mechanism of antiinflammatory and antithermal burn action of CPase from <i>Aloe arborescens</i> Miller var. <i>natalensis</i> Berger in rats and mice

Obata, Masafumi; Itô, Shôsuke; Beppu, Hidehiko; Fujita, Kazuo; Nagatsu, Toshiharu

doi:10.1002/ptr.2650070711

Cited by 25 publications

(15 citation statements)

References 19 publications

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“…The ammonium sulphate precipitated fraction of the A. vera gel also reported for in-vitro anti-bradykinin activity [31] and a 14 kDa radical scavenging glycoprotein had been reported for inhibiting cyclooxygenase-2 and thromboxane A2 synthase from A. vera gel [23]. Another study reported a carboxy-peptidase activity of the A. vera leaf gel, inactivates bradykinins and produces an antiinflammatory effect [32,33]. It has been reported earlier that aqueous extract from A. vera gel showed anti-inflammatory activity by inhibiting the action of arachidonic acid pathway via cyclooxygenase [34].…”

Section: Discussionmentioning

confidence: 92%

Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel

Das

Mishra

Gill

et al. 2011

International Journal of Biological Macromolecules

108

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Section: Discussionmentioning

confidence: 92%

Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel

Das

Mishra

Gill

et al. 2011

International Journal of Biological Macromolecules

108

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“…In the present study, it was observed that Aloe vera could modulate Salmonella OmpR mediated inflammation. It significantly reduced hyperalgesia which may be attributed to inhibition of prostaglandins production (Langmead et al, 2004) and due to the release of an enzyme known as carboxypeptidase which hydrolyses bradykinin (Obata et al, 1993;Shelton, 1991;Bautista-Perez et al, 2004) thus resulting in an analgesic effect. The results coincide well with those reported by Sarkar et al (2005).…”

Section: Discussionmentioning

confidence: 98%

Phytomodulatory potentials of Aloe vera against Salmonella OmpR‐mediated inflammation

Rishi

Rampuria

Tewari

et al. 2008

Phytotherapy Research

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Mediators released during inflammatory response play an essential role in eliminating microbes or microbial products. However, the uncontrolled release of cytotoxic substances characterized by extensive inflammation may adversely affect normal tissues. Under such conditions it is important to manage the hyperinflammation in order to change the clinical manifestations of the disease. Accordingly, the present study was designed to evaluate the modulation of Salmonella OmpR mediated inflammation by Aloe vera, a plant known to contain antiinflammatory ingredients. It was observed that outer-membrane proteins (OMPs) extracted from the wild type strain of S. typhimurium caused inflammation of greater magnitude compared with the OMPs extracted from its mutant construct as evident from the oedema test as well as the hyperalgesic (flicking) response of the animals under experimental conditions. However, Aloe vera applied topically, administered intraperitoneally or in combination modulated the inflammatory response. The maximum effect was observed with the combined formulation indicating modulation at local as well as systemic levels. The results reveal that this modulation could be due to the potential of Aloe vera to decrease peroxidative damage via a decrease in the levels of monokines (TNF-alpha, IL-1 and IL-6) and an increase in the level of superoxide dismutase (SOD). Moreover, the presence of SOD in Aloe vera itself might be responsible for enhancing its levels in the macrophages. On the other hand, no significant change in the catalase activity was observed by Aloe vera treatment. The use of Aloe vera, therefore, seems to have a promising role in the modulation of Salmonella OmpR mediated inflammation.

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“…Several previous studies indicated the presence of anthraquinone aloin, polysachharides, reducing sugars, organic acids, glycoproteins, sterols, terpenes, etc. in Aloe preparations [20,21].…”

Section: Spectral Analysismentioning

confidence: 99%

In Vivo Evalution of Hypoglycemic Activity of Aloe spp. and Identification of Its Mode of Action on GLUT-4 Gene Expression In Vitro

Kumar

Sharma

Tomar

et al. 2011

Appl Biochem Biotechnol

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The present study evaluated the hypoglycemic activity of Aloe extract on streptozotocin-induced diabetic mice and focuses its effect on GLUT-4 gene expression under in vitro cell-culture system. Administration of extract at the dosage of 130 mg/kg body weight per day for 4 weeks resulted in significant decrease in blood glucose and total cholesterol in streptozotocin (60 mg/kg body weight) induced diabetic mice. The hypoglycemic effect was compared with metformin. The activities of carbohydrate metabolizing enzymes were brought back to near normal level after the treatment and glucose homeostasis was maintained. Lyophilized aqueous Aloe extract (1 mg/ml) upregulated the GLUT-4 mRNA synthesis in mouse embryonic NIH/3T3 cells.

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Mechanism of antiinflammatory and antithermal burn action of CPase from Aloe arborescens Miller var. natalensis Berger in rats and mice

Cited by 25 publications

References 19 publications

Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel

Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel

Phytomodulatory potentials of Aloe vera against Salmonella OmpR‐mediated inflammation

In Vivo Evalution of Hypoglycemic Activity of Aloe spp. and Identification of Its Mode of Action on GLUT-4 Gene Expression In Vitro

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