In Vivo Evalution of Hypoglycemic Activity of Aloe spp. and Identification of Its Mode of Action on GLUT-4 Gene Expression In Vitro

Kumar, Rajiv; Sharma, Bhavna; Tomar, Neha R.; Roy, Partha; Gupta, Atul; Kumar, Anil

doi:10.1007/s12010-011-9210-6

Cited by 37 publications

(20 citation statements)

References 28 publications

(28 reference statements)

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“…Metformin acts by reducing the plasma glucose level, increasing the uptake of glucose by skeletal muscle cells through GLUT or insulin receptors. Therefore, the upregulation of GLUT-4 caused by the extract may be due to a stimulus of cytoskeletal proteins, which act in the transport of GLUT-4 vesicles from the cytoplasm to plasma membrane [32].…”

Section: Aloe Veramentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Section: Aloe Veramentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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“…IC 50 value for inhibition of alpha‐glucosidase is 22.0 ± 1.26 (Wu et al, ). Lyophilized aloe gel from Aloe barbedensis contains aloe‐emodin‐8‐O‐glycoside, which enhances glucose transport by modulating the proximal and distal markers involved in glucose uptake and its transformation into glycogen while modulating the expression level of GLUT4 and decreasing the activity of hexokinases (Kumar et al, ). It also inhibited the protein tyrosine phosphatase in a dose‐dependent manner (Anand et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…Luteolin isolated from Aloe vera Tourn showed inhibition of procaine pancreatic alpha‐amylase with IC 50 of 50–500 μg/ml (Kumar et al, ; Mishra, Rao, Ojha, Vijayakumar, & Verma, ). Isolated compounds anacardic acids and cardols from Anacardium occidentale are reported to be potent inhibitors of alpha‐glucosidases with IC 50 ranging from 1.1–6.1 μM (Toyomizu, Sugiyama, Jin, & Nakatsu, ).…”

Section: Methodsmentioning

confidence: 99%

Enzymes inhibitors from natural sources with antidiabetic activity: A review

Alam

Shafique

Amjad

et al. 2018

Phytotherapy Research

119

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Natural products have been extensively investigated for antidiabetic therapy. Many of the natural products have direct or indirect effect in diabetes pathways as enzyme inhibitors. The most involved mechanisms are inhibition of intestinal alphaglucosidase and alpha-amylase, lens aldose reductase, oxidative stress protection, inhibition of formation of advanced glycation end products, inhibition of aldose reductase, lowering plasma glucose levels, altering enzyme activity of hexokinases and glucose-6-phosphate, synthesizing and releasing of insulin, postprandial hyperglycemia inhibition, stimulation of GLUT-4, decreasing activity of G6P, lowering the level of skeletal hexokinases, etc. The following medicinal plants products or extracts showed promising effects as enzyme inhibitors:officinale. Some of the group of phytochemicals isolated with enzyme inhibition activities are Alkaloids, sesquiterpene and saponins, polysaccharides, flavonoids, dietary fibers, ferulic acid, tannins, limonene, and oleuropeoside. This review will provide very useful material to enhance the efficiency of rational antidiabetic drug design.

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“…Leaves Aqueous Cutting down the levels of blood glucose, TG, LDL, and TC Streptozotocin-induced diabetic mice [313] Ameliorating insulin secretion and pancreatic β-cell function, i.e., boosting pancreatic islet mass Streptozotocin-induced diabetic rats [314] Ameliorating glucose metabolism by way of cutting down the level of blood glucose Alloxan-induced diabetic rats [315] 6…”

Section: Aloe Veramentioning

confidence: 99%

Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review

Unuofin

Lebelo

2020

Oxidative Medicine and Cellular Longevity

173

114

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Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory responses and beta cell dysfunction. This ailment affects as many as 451 million people worldwide, and it is also one of the leading causes of death. In spite of the immense advances made in the development of orthodox antidiabetic drugs, these drugs are often considered not successful for the management and treatment of T2DM due to the myriad side effects associated with them. Thus, the exploration of medicinal herbs and natural products as therapeutic sources for the treatment of T2DM is promoted because they have little or no side effects. Bioactive molecules isolated from natural sources have been proven to lower blood glucose levels via regulating one or more of the following mechanisms: improvement of beta cell function, insulin resistance, glucose (re)absorption, and glucagon-like peptide-1 homeostasis. In recent times, the mechanisms of action of different bioactive molecules with antidiabetic properties and phytochemistry are gaining a lot of attention in the area of drug discovery. This review article presents an update of the findings from clinical research into medicinal plant therapy for T2DM.

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In Vivo Evalution of Hypoglycemic Activity of Aloe spp. and Identification of Its Mode of Action on GLUT-4 Gene Expression In Vitro

Cited by 37 publications

References 28 publications

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Enzymes inhibitors from natural sources with antidiabetic activity: A review

Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review

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