Antibody Response to
            <i>Actinomyces</i>
            Antigen and Dental Caries Experience: Implications for Caries Susceptibility

Levine, Martin; Owen, William J.; Avery, Kevin T.

doi:10.1128/cdli.12.6.764-769.2005

Cited by 8 publications

(7 citation statements)

References 40 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with African-Americans, the caries experience of Db-positive Caucasians was less in magnitude and not significant. In Caucasian young adults, factors that enhance antibody responses to actinomyces, presumably by increasing the extent of actinomyces colonization, minimize caries development (Levine et al, 2005). This study suggests that acidic PRP alleles in linkage disequilibrium with Db could enhance the mutualistic growth of actinomyces in biofilms, and promote the observed antibodies and reduced caries experience observed in young adult Caucasians.…”

Section: Discussionmentioning

confidence: 63%

“…For example, S. mutans binding to parotid saliva-coated apatite is enhanced along with caries if the Db allele of PRH1 is expressed as the Db protein in saliva, but Actinomyces naeslundii binding is enhanced if the Db protein is absent (Stenudd et al, 2001). Thus, in the absence of Db, increased colonization by A. naeslundii may promote a high antibody response that associates with less caries in adults (Levine et al, 2005). Different acidic PRP mixtures may therefore promote different mutualistic bacterial interactions (Yoshida et al, 2006) that influence the extent of biofilm colonization by acidogenic and aciduric bacteria responsible for caries.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acidic Proline-rich Protein Db and Caries in Young Children

et al. 2007

View full text Add to dashboard Cite

Polymorphic, acidic proline-rich proteins (PRPs) in saliva influence the attachment of bacteria associated with caries. Our aims were to detect one of three acidic PRP alleles of the PRH1 locus (Db) using polymerase chain-reaction (PCR) on genomic DNA, and to determine its association with caries. DNA was obtained from buccal swabs from Caucasian and African-American children, and their caries experience was recorded. PCR primers designed around exon 3 of the PRH1 locus gave a 416-base product representing Db and a 353-base product representing the other two alleles (Pa or Pif). In Caucasians, Db gene frequency was 14%, similar to Db protein from parotid saliva. In African-Americans, however, it was 37%, 18% lower than Db from parotid saliva (reported previously). Compared with African-Americans, all Caucasians had significantly greater Streptococcus mutans colonization, but only Db-negative Caucasians had significantly more caries. Alleles linked to Db may explain racial differences in caries experience.

show abstract

Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Acidic Proline-rich Protein Db and Caries in Young Children

et al. 2007

View full text Add to dashboard Cite

show abstract

“…It has been assumed that the presence of black stain is associated with low cariogenic oral microflora with a predominance of actinomycetes and low numbers of streptococci (8–10). Following recent immunological studies and investigations on bacterial adhesion, high levels of Actinomyces naeslundii in biofilms on teeth correlated with low caries experience and low mutans streptococci adhesion (17, 18). Thus, bacterial composition of biofilms on teeth has an influence on susceptibility and resistance to dental caries (18).…”

Section: Discussionmentioning

confidence: 99%

Black stain and dental caries in Filipino schoolchildren

Heinrich‐Weltzien¹,

Monse²,

Helderman³

2009

Comm Dent Oral Epid

View full text Add to dashboard Cite

show abstract

“…This suggestion is supported by the reported increased Actinomyces antibody level associated with increased Actinomyces sp. colonization and lower caries experience [Levine et al, 2005]. Thus, bacterial composition of the microbiota may modulate susceptibility and resistance to dental caries [Stenudd et al, 2001].…”

Section: Discussionmentioning

confidence: 99%

Dental Caries and Microbiota in Children with Black Stain and Non-discoloured Dental Plaque

2013

View full text Add to dashboard Cite

Aim: We aimed to assess caries experience and microbiota in systemically healthy children with black stain (BS) and non-discoloured plaque. Methods: Forty-six children with BS and 47 counterparts with non-discoloured plaque aged 7.9 ± 1.3 years were clinically examined. Dental caries was scored using WHO criteria. Samples of BS and non-discoloured dental plaque were collected from tooth surfaces. The DNA of the samples was extracted and real-time PCR was performed to determine the total number of bacteria and the species Streptococcus mutans, S. sobrinus, Lactobacillus sp., Actinomyces naeslundii, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. Results: Children with BS had lower DMFT (p = 0.013), lower DT values (p = 0.005) and a tendency to lower caries prevalence (p = 0.061) than children with non-discoloured plaque. Plaque samples of the BS group contained higher numbers of A. naeslundii (p = 0.005) and lower numbers of F. nucleatum (p = 0.001) and Lactobacillus sp. (p = 0.001) compared to the non-discoloured plaque samples of the control group. Comparing the children with BS and non-discoloured plaque, higher counts for A. naeslundii (p = 0.013) were observed in caries-free children with BS while in caries-affected children with BS, lower counts of F. nucleatum (p = 0.007) were found. Counts of Lactobacillus sp. were higher in non-discoloured plaque samples than in BS of caries-free and caries-affected children. Conclusion: Results suggest that the different microbial composition of BS might be associated with the lower caries experience in affected subjects. The role of black-pigmented bacteria associated with periodontitis needs further studies.

show abstract

Antibody Response to Actinomyces Antigen and Dental Caries Experience: Implications for Caries Susceptibility

Abstract: Fluoridated dentifrices reduce dental caries in subjects who perform effective oral hygiene. Actinomyces naeslundii increases in teeth-adherent microbial biofilms (plaques) in these subjects, and a well-

Cited by 8 publications

References 40 publications

Acidic Proline-rich Protein Db and Caries in Young Children

Acidic Proline-rich Protein Db and Caries in Young Children

Black stain and dental caries in Filipino schoolchildren

Dental Caries and Microbiota in Children with Black Stain and Non-discoloured Dental Plaque

Contact Info

Product

Resources

About