Acidic Proline-rich Protein Db and Caries in Young Children

Zakhary, George; Clark, Richard M.; Bidichandani, Sanjay I.; Owen, William J.; Slayton, Rebecca L.; Levine, Martin

doi:10.1177/154405910708601207

Cited by 45 publications

(31 citation statements)

References 28 publications

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“…The sample sizes were notably variable, including from 30 to 920 individuals. About half of the selected studies analyzed children, 13,14,18,19,20 evaluating primary and permanent dentition, while the other half studied only adults. 12,15,21,22,23,24 Dental caries prevalence was evaluated according to the number of decayed, missing, and filled teeth.…”

Section: Resultsmentioning

confidence: 99%

“…38 Acidic PRPs are encoded by two genes, PRH1 and PRH2, with three different alleles at PRH1 (Db, Pa, and Pif). 39 When the allele Db was studied, 20 it was present in 72% of African Americans and in 26% of Caucasians. Curiously enough, large groups of African American children, regardless of the presence of Db, had significantly less caries experience than Caucasian subjects (p < 0.01).…”

Section: Records Identified Through Database Search (N= 424)mentioning

confidence: 99%

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Salivary protein polymorphisms and risk of dental caries: a systematic review

et al. 2017

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Dental caries is an oral pathology associated with both lifestyle and genetic factors. The caries process can be influenced by salivary composition, which includes ions and proteins. Studies have described associations between salivary protein polymorphisms and dental caries experience, while others have shown no association with salivary proteins genetic variability. The aim of this study is to assess the influence of salivary protein polymorphisms on the risk of dental caries by means of a systematic review of the current literature. An electronic search was performed in PubMed, Scopus, and Virtual Health Library. The following search terms were used: "dental caries susceptibility," "dental caries," "polymorphism, genetics," "saliva," "proteins," and "peptides." Related MeSH headings and free terms were included. The inclusion criteria comprised clinical investigations of subjects with and without caries. After application of these eligibility criteria, the selected articles were qualified by assessing their methodological quality. Initially, 338 articles were identified from the electronic databases after exclusion of duplicates. Exclusion criteria eliminated 322 articles, and 16 remained for evaluation. Eleven articles found a consistent association between salivary protein polymorphisms and risk of dental caries, for proteins related to antimicrobial activity (beta defensin 1 and lysozyme-like protein), pH control (carbonic anhydrase VI), and bacterial colonization/adhesion (lactotransferrin, mucin, and proline-rich protein Db). This systematic review demonstrated an association between genetic polymorphisms and risk of dental caries for most of the salivary proteins.

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Section: Resultsmentioning

confidence: 99%

Section: Records Identified Through Database Search (N= 424)mentioning

confidence: 99%

Salivary protein polymorphisms and risk of dental caries: a systematic review

et al. 2017

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“…Also, an association between caries and saliva levels of specific proline-rich proteins (encoded by PRH1 and PRH2 genes), a saliva component that influences the attachment of bacteria, was reported [Zakhary et al, 2007]. Genetics also controls saliva function as there is evidence of association between buffer capacity and polymorphisms in the carbonic anhydrase 6 gene in children [Peres et al, 2010].…”

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confidence: 99%

MMP13 Polymorphism Decreases Risk for Dental Caries

Tannure

Küchler²,

Falagan-Lotsch

et al. 2012

Caries Res

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Recent evidence suggests that genetic studies may contribute to a better understanding of individual susceptibility to caries. Matrix metalloproteinases (MMPs) and their tissue inhibitors have been suggested to be involved in the caries process. The purpose of this study was to determine if polymorphisms in MMP2 (rs243865), MMP9 (rs17576), MMP13 (rs2252070), and TIMP2 (rs7501477) were associated with caries. Eligible unrelated children and adolescents were evaluated using a cross-sectional design. Data on oral health habits was obtained through a questionnaire and caries data was collected by clinical examination. Genotyping of the selected polymorphisms was carried out by real-time PCR. Allele and genotype frequencies were compared between individuals with and without caries experience. Of 505 subjects, 212 were caries-free and most subjects (61.2%) had mixed dentition. Allele frequency of MMP2, MMP13 and TIMP2 was different between caries-affected and caries-free individuals, with significant association for MMP13 (p = 0.004). Mutant allele carriers for MMP13 demonstrated a significantly decreased risk for caries (OR = 0.538, 95% CI 0.313–0.926); this result remained significant after adjustment for candidate genes, type of dentition and dietary factors. Allelic and genotype frequencies of the polymorphism in MMP9 were similar in caries-affected and caries-free individuals. Genetic variations in MMP13 may contribute to individual differences in caries susceptibility. Our findings reinforce that susceptibility to caries results from gene-environment interactions.

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“…Copyright © 2008 S. Karger AG, Basel A genetic susceptibility to caries has been proposed based on twin studies [reviewed by Shuler, 2001], family studies [Klein and Palmer, 1940;Klein, 1946] and animal models [Hunt et al, 1944;Rosen et al, 1961]. The earlier molecular genetic studies in humans focused on prolinerich peptides in saliva [Yu et al, 1986;Ayad et al, 2000;Young et al, 2002;Zakhary et al, 2007] and enamel formation genes [Slayton et al, 2005;Deeley et al, 2008]. More recently, a genome-wide scan searching for caries susceptibility and protective loci was performed, and suggestive loci influencing caries were proposed .…”

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confidence: 99%

Enamel Formation Genes Are Associated with High Caries Experience in Turkish Children

et al. 2008

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There is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes and their interaction with Streptococcus mutans levels may contribute to caries. For the present study, we used DNA samples collected from 173 unrelated children from Istanbul: 91 children with 4 or more affected tooth surfaces and 82 caries-free children. Six single-nucleotide polymorphism markers were genotyped in selected candidate genes (ameloblastin, amelogenin, enamelin, tuftelin 1 and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Regression analysis was used for the evaluation of individual gene effects, environmental effects and gene-environment interactions. Overrepresentation of the C allele of the amelogenin marker was seen in cases with dmft scores higher than 8 (p = 0.01) when compared to controls. Also, overrepresentation of the T allele of the ameloblastin marker was seen in cases with dmfs scores higher than 10 (p = 0.05) when compared to controls. In addition, the CT genotype of the tuftelin rs3790506 marker was overrepresented in cases with dmft scores higher than 5 (p = 0.05) and dmfs scores higher than 6 (p = 0.05) compared to controls. The best-fitting model showed that dmfs is increased when the following factors are present: (1) females and both the anterior and posterior teeth are affected simultaneously, (2) when the T allele of the tuftelin rs3790506 is involved, and (3) the C allele of the amelogenin rs17878486 is involved. Our study provides support that genes involved in enamel formation modify caries susceptibility in humans.

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Acidic Proline-rich Protein Db and Caries in Young Children

Cited by 45 publications

References 28 publications

Salivary protein polymorphisms and risk of dental caries: a systematic review

Salivary protein polymorphisms and risk of dental caries: a systematic review

<b><i>MMP13</i></b> Polymorphism Decreases Risk for Dental Caries

Enamel Formation Genes Are Associated with High Caries Experience in Turkish Children

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