1995
DOI: 10.1016/0020-7519(94)00160-p
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Antibody degradation in wound exudates from blowfly infections on sheep

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Cited by 17 publications
(8 citation statements)
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“…Pruett (3) showed that Hypodermin A cleaves bovine IgG. In the same manner, Lucilia cuprina (Calliphoridae) larvae contain digestive tryptic and chymotryptic proteases involved in larval nutrition (4) and avoidment of cellular (5,6) and humoral immune responses, with cleavage of IgG (7–9). Moreover, excretion of ammonia by L. cuprina larvae suppresses immunity in sheep (10).…”
Section: Introductionmentioning
confidence: 99%
“…Pruett (3) showed that Hypodermin A cleaves bovine IgG. In the same manner, Lucilia cuprina (Calliphoridae) larvae contain digestive tryptic and chymotryptic proteases involved in larval nutrition (4) and avoidment of cellular (5,6) and humoral immune responses, with cleavage of IgG (7–9). Moreover, excretion of ammonia by L. cuprina larvae suppresses immunity in sheep (10).…”
Section: Introductionmentioning
confidence: 99%
“…Previous work on D. hominis adaptive immune response on cattle showed the same tendency, with 90% of the animals presenting antibodies against D. hominis prior to experimental infestation (CORONADO-FONSECA, 1989). SANDEMANN et al (1995), as well as BARON & NELSON (1985), seeking for antibodies titres to Lucilla cuprina and Melophagus ovinus, respectively, in experimentally infested sheep observed gradual augments of serum antibodies, which decreased on few weeks after exposition. These authors concluded that adaptive immune response against L. cuprina and M. ovinus should occurs only when larval infestation was active.…”
Section: Resultsmentioning
confidence: 80%
“…A number of reports identified the production of serum antibodies to various larval antigens post-vaccination and subsequent antilarval growth effects in vitro (54-61); however, these results generally did not translate into significant protection following implants with first-stage larvae in vivo. The reasons for this apparent inability to translate in vitro effects to the in vivo situation were suggested to include insufficient antibody titres present in the skin, the degradation of IgG at the wound site and the time required to reach peak antibody titres in the sera (40,62,63). In contrast to the reports where vaccination failed to illicit a protective response in vivo was the study by Bowles et al (64), in which vaccination with four partially purified antigens induced an 86% (Trial 1) and a 67% (Trial 2) reduction in the incidence of strike compared to unvaccinated controls.…”
Section: Vaccine Responsesmentioning
confidence: 99%