The immunobiology of myiasis infections – whatever happened to vaccination?

Sandeman, R.M.; Bowles, Vernon M; Colwell, Douglas D.

doi:10.1111/pim.12128

Cited by 10 publications

(5 citation statements)

References 119 publications

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“…are responsible for cutaneous myiasis, also known as blowfly strike, with a substantial economic impact on the wool industry (Elkington and Mahony, 2007 ). The immune responses to blowfly strike and vaccine development have been reviewed extensively (Elkington and Mahony, 2007 ; Sandeman et al, 2014 ). Many studies have focused on raising protective antibodies against a range of antigens derived from L. cuprina larvae including: cuticle proteins (Barrett and Trevella, 1989 ); whole larvae extracts (East et al, 1992 ); fractionated larval extracts (Tellam and Eisemann, 1998 ); excretory and secretory (ES) products (Bowles et al, 1987 ; Tellam et al, 1994 ); purified serine-proteases (Tellam et al, 1994 ) and larval peritrophin membrane proteins (Casu et al, 1997 ; Tellam and Eisemann, 1998 ; Colditz et al, 2002 ).…”

Section: Ectoparasite Vaccines: Parasitic Arthropodsmentioning

confidence: 99%

“…Combining such in silico methods with manual inspection, literature searches and even additional bioassays, will assist functional annotation of transcripts that lack sequence homology to model organisms (De La Fuente et al, 2016a ; Haçariz and Sayers, 2016 ; Lew-Tabor and Valle, 2016 ). In this regard, additional reverse genetics approaches such as gene knock-down (e.g., RNAi) and gene editing (CRISPR/Cas9) have been successful in describing in vivo protein function for parasitic and non-parasitic (e.g., Caenorhabditis elegans and Drosophila melanogaster ) helminths and arthropods, as well as evaluation of potential targets for parasite/vector control (e.g., expressed library immunization or ELI and phage display) (Dalvin et al, 2009 ; Ellis et al, 2012 ; Waaijers et al, 2013 ; Sandeman et al, 2014 ; Tröße et al, 2014 ; Aghebati-Maleki et al, 2016 ; Britton et al, 2016 ; De La Fuente et al, 2016a ; Zamanian and Andersen, 2016 ; Crauciuc et al, 2017 ; Gao et al, 2017 ; Macias et al, 2017 ; Rahumatullah et al, 2017 ).…”

Section: Metazoan Vaccine Development: Identification To Formulationmentioning

confidence: 99%

See 1 more Smart Citation

Metazoan Parasite Vaccines: Present Status and Future Prospects

Stutzer

Richards

Ferreira

et al. 2018

Front. Cell. Infect. Microbiol.

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Eukaryotic parasites and pathogens continue to cause some of the most detrimental and difficult to treat diseases (or disease states) in both humans and animals, while also continuously expanding into non-endemic countries. Combined with the ever growing number of reports on drug-resistance and the lack of effective treatment programs for many metazoan diseases, the impact that these organisms will have on quality of life remain a global challenge. Vaccination as an effective prophylactic treatment has been demonstrated for well over 200 years for bacterial and viral diseases. From the earliest variolation procedures to the cutting edge technologies employed today, many protective preparations have been successfully developed for use in both medical and veterinary applications. In spite of the successes of these applications in the discovery of subunit vaccines against prokaryotic pathogens, not many targets have been successfully developed into vaccines directed against metazoan parasites. With the current increase in -omics technologies and metadata for eukaryotic parasites, target discovery for vaccine development can be expedited. However, a good understanding of the host/vector/pathogen interface is needed to understand the underlying biological, biochemical and immunological components that will confer a protective response in the host animal. Therefore, systems biology is rapidly coming of age in the pursuit of effective parasite vaccines. Despite the difficulties, a number of approaches have been developed and applied to parasitic helminths and arthropods. This review will focus on key aspects of vaccine development that require attention in the battle against these metazoan parasites, as well as successes in the field of vaccine development for helminthiases and ectoparasites. Lastly, we propose future direction of applying successes in pursuit of next generation vaccines.

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Section: Ectoparasite Vaccines: Parasitic Arthropodsmentioning

confidence: 99%

Section: Metazoan Vaccine Development: Identification To Formulationmentioning

confidence: 99%

Metazoan Parasite Vaccines: Present Status and Future Prospects

Stutzer

Richards

Ferreira

et al. 2018

Front. Cell. Infect. Microbiol.

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“…Vaccination for the control of Lucilia spp. has also been an area of intensive research over the last 20 years but has not advanced far, probably because of the complex relationship with its host and because the infection proceeds so rapidly (reviewed by Elkinton and Mahoney 2007;Sandeman et al 2014). Recent work on both a draft genome and a transcriptome of L. cuprina have been described by Anstead et al (2016).…”

Section: Biology Of Lucilia Sppmentioning

confidence: 99%

7. Prevention and control of tick-borne anaplasmosis, cowdriosis and babesiosis in the cattle industry

Pfeffer

Król

Obiegala

2018

Pests and Vector-Borne Diseases in the Livestock Industry

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Worldwide the livestock industry, from small farmers to large industrialized farms, is affected by arthropods and arthropod-borne diseases at various scales, which cause huge losses and are a constraint to socio-economic development. Farmers make considerable efforts to prevent and control pest and disease incidence, often requiring the use of vaccines, if available, drugs and pesticides. Examples of current problems are presented, to set the stage for the detailed and state-of-the-art presentations of specific cases of livestock pests and their associated diseases and modern methods of prevention and control.

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“…The development of vaccines against Hypoderma spp. has been relatively slowed for more than 10 years despite the rapid development of genomic and proteomic analysis and of skills in data interpretation (Sandeman et al, 2014). Cattle develop resistance to Hypoderma spp.…”

Section: Vaccinesmentioning

confidence: 99%

Untitled

2018

Int. J. Adv. Agric. Res.

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Cattle hypodermosis (warble fly infestation, WFI) is an economically important disease in livestock throughout the world. Larvae of Hypoderma spp. cause subcutaneous myiasis of domesticated and wild ruminants. The important species in cattle are Hypoderma bovis and Hypoderma lineatum whereas, Hypoderma diana, Hypoderma actaeon and Hypoderma tarandi, affect roe deer, red deer, and reindeer, respectively. Hypoderma crossi infects sheep and goat. Adults of the cattle grub are commonly known as heel flies, warble flies, bomb flies or gad flies. The larval stages of Hypoderma bovis and Hypoderma lineatum are commonly called 'ox warbles'. The biology of hypodermosis is complex in nature. The parasitic larval stage of Hypoderma spp. spend about one year in domesticated as well as in the wild animals, while the adult free-living stage lasts only for few days. The disease causes heavy economic losses to animal production like milk and leather industry. It can also affect the general health status as well as the immune system of the body of the diseased animals. The early diagnosis of hypodermosis is of great importance for planning treatment and eradication program. The control measures of the disease have been efficiently practiced and consequently this disease is controlled at national level in many European countries. Keeping in view the importance of the disease, the present review intends to underscore and provide up to date information about the overall aspect of hypodermosis in animals with the existing literature available with special emphasis on hypodermosis on cattle.

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The immunobiology of myiasis infections – whatever happened to vaccination?

Cited by 10 publications

References 119 publications

Metazoan Parasite Vaccines: Present Status and Future Prospects

Metazoan Parasite Vaccines: Present Status and Future Prospects

7. Prevention and control of tick-borne anaplasmosis, cowdriosis and babesiosis in the cattle industry

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