<i>Oestrus ovis</i> (Diptera: Oestridae): effects of larval excretory/secretory products on nitric oxide production by murine RAW 264·7 macrophages

Tabouret, Guillaume; Vouldoukis, Ioannis; Duranton, C.; Prévot, Françoise; Bergeaud, Jean-Paul; Dorchies, P.; Mazier, Dominique; Jacquiet, P.

doi:10.1046/j.1365-3024.2001.00355.x

Cited by 7 publications

(8 citation statements)

References 42 publications

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“…As expected, over the period 1994-2000, no seropositive roe deer was detected by ELISA, since the first report dates 2001 [26]. However, 38% (CI [35][36][37][38][39][40][41][42] of roe deer hunted between 2007 and 2014 showed C. stimulator antibodies. It is worth noting that the presence of specific antibodies indicates exposure to the parasite but not necessarily an active infestation.…”

Section: Prevalence and Infestation Intensitysupporting

confidence: 53%

An Update on Cephenemyiosis in the European Roe Deer: Emergent Myiasis in Spain

Morrondo

Pajares

Arias

et al. 2021

Animals

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Cephenemyia stimulator is a Palearctic species developing in the nasal cavity and pharynx of roe deer (Capreolus capreolus). It is widely spread in the range of distribution of this ungulate in Europe. Since the first report of C. stimulator in Spain in 2001, a rapid geographic expansion has been observed, first in the north of the country, with high prevalence and intensities of infestation that caused some mortal cases, and, lately, also in Extremadura and Andalucía, the southernmost populations of European roe deer. These observations suggest an adaptation of this parasite to different ecosystems of the Iberian Peninsula. Almost simultaneously, C. stimulator is also expanding its range to northern Europe, with the first cases being reported in Sweden. Thus, Cephenemyia stimulator may be an example of a parasite currently displaying distributional changes along its southernmost and northernmost range margins. Thus, it is of the utmost importance to unravel all the epidemiological and clinical aspects of this myiasis, as well as implementing surveillance measures including reliable and non-invasive diagnostic techniques to monitor its expansion and adaptation to different ecosystems and/or hosts and to reduce the negative impact on roe deer populations.

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Section: Prevalence and Infestation Intensitysupporting

confidence: 53%

An Update on Cephenemyiosis in the European Roe Deer: Emergent Myiasis in Spain

Morrondo

Pajares

Arias

et al. 2021

Animals

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“…By contrast, in vitro assays have demonstrated that O. ovis larval extracts, mainly L2 somatic extracts, induce nitric oxide (NO) production by macrophages . Interestingly, products excreted/secreted by larvae were also able to induce NO production in murine RAW 264.7 macrophages (Tabouret et al, 2001b). Induction of NO in these tumoral cells was principally linked to a 29-kDa protein secreted by the larval salivary glands.…”

Section: Immunostimulationmentioning

confidence: 97%

“…Nitric oxide induces tissue damage, vasodilatation and plasma protein leakage. Thus, although an NO burst may be harmful to the host, the plasma protein leakage and hypersecretion induced by excreted/secreted larval products may be a source of food and nutrients for larvae (Tabouret et al, 2001b(Tabouret et al, , 2003b. -Charrier & Dorchies (1993) reported for the first time that in vitro lymphocyte proliferation decreased and mitotic activity was depleted to levels comparable with those in non-infected lambs on days 19 and 33 post-infection, respectively.…”

Section: Immunostimulationmentioning

confidence: 99%

Sheep and goat immune responses to nose bot infestation: a review

Angulo

Ascencio

Jacquiet

et al. 2010

Medical and Veterinary Entomology

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Abstract. Oestrus ovis L. (Diptera: Oestridae) is a cosmopolitan agent of myiasis in sheep and goats. The parasitic phase begins after adult females deposit first-stage larvae (L1) into the nostrils of hosts; these larvae develop into L2 and L3 in the nasal and sinus horn cavities. Sneezing and nasal discharges are the major clinical signs in infected animals. The pathogenesis of O. ovis infection is caused by: (a) the trauma resulting from the mechanical action of spines and hooks during larval movement on mucosal membranes, and, more importantly, (b) an allergenic reaction provoked by molecules excreted/secreted by larvae, of which salivary antigens are those mainly recognized by the host's immune system. The recruitment of immune reactive cells increases gradually from the nasal to sinus cavities in infected hosts. Mast cells, eosinophils, macrophages and lymphocytes are always more numerous in infected than non-infected animals. Humoral (antibody) systemic response of immunoglobulin G (IgG) usually reaches seroconversion 2-4 weeks post-first infection and the highest levels are observed during the development of L2 and L3 larvae. Local antibody responses include specific IgG, which has been found to negatively correlate with larval survival and development. Hypersensitivity reaction, immunomodulation, immunization trials and mixed infections of O. ovis and helminths are discussed.

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“…Although their hooks and spines injure the nasal membranes, larval nutrition is not only mechanical but mainly related to a biochemical process and huge nitrogen oxide liberation has been observed. Indeed, Tabouret et al (2001c) have shown, in vitro, that ESP could stimulate nitric oxide production inducing plasma protein leakage. This up regulation is time and dose-dependent.…”

Section: Larval Nutritionmentioning

confidence: 99%