Antibody-Based Therapies for Cutaneous T-Cell Lymphoma

Welborn, Macartney; Duvic, Madeleine

doi:10.1007/s40257-018-0402-5

Cited by 22 publications

(25 citation statements)

References 41 publications

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“…The IPH4102, a humanized monoclonal antibody directed against the KIR3DL2 cell receptor (CD158K), has also been proposed. Finally, histone deacetylase (HDAC) inhibitors (romidepsin and vorinostat) and demethylating agents have demonstrated efficacy in inducing cell cycle arrest, differentiation, and/or apoptosis of tumor cells [35][36][37][38].…”

Section: Therapiesmentioning

confidence: 99%

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training

Sica

Vitiello

Ronchi

et al. 2020

IJERPH

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Primary cutaneous anaplastic large cell lymphoma (pcALCL) is part of a spectrum of cutaneous CD30+ lymphoproliferative disease that also includes lymphomatoid papulosis. It often occurs in elderly patients, presenting at a median age of 60 years, although it may occur at any age. It is a CD30+ T-cell neoplasm composed of large cells with anaplastic, pleomorphic, or immunoblastic morphology, with exclusively cutaneous onset and localization. The clinical course of pcALCL is predominantly indolent. Most elderly patients with lymphoma tend to have a sedentary lifestyle, which has a negative effect on their quality of life (QoL) and survival. Several studies indicate that exercise has a positive impact on QoL because it reduces peak oxygen consumption, improves physical capacity, increases self-esteem, reduces accumulated stress, and promotes relaxation. Therefore, particularly in indolent lymphomas, it is necessary to indicate a program of physical activity to be practiced systematically. Complete surgical excision and local radiotherapy are the first line gold standard in pcALCL with a solitary lesion.

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Section: Therapiesmentioning

confidence: 99%

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training

Sica

Vitiello

Ronchi

et al. 2020

IJERPH

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“…Genomic analysis in mycosis fungoides [33] A Oncogenes upregulated MALAT1, MECOM, PBX1, TTK, WWTR1 gets the immune receptor KIR3DL2/CD158k). [36][37][38][39][40][41] Targeting CD47 is expressed on all normal cells, targets SIRPα on the surface of myeloid cells and may be a new cancer therapeutic strategy also in cutaneous T-cell lymphoma.…”

Section: How Ha S the Field Pur Sued This Line Of Re S E Arch In Thmentioning

confidence: 99%

Molecular pathogenesis of cutaneous lymphoma–Future directions

Stadler

Hain

Cieslak

et al. 2020

Experimental Dermatology

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Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin lymphomas of mainly mature skin homing CD4 + T cells. [1] The current WHO classification comprises eight main types of cutaneous T-cell lymphomas. The most frequent subtype is Mycosis fungoides (MF) with about 60% of all cases. Sézary syndrome (SS) is another well-known CTCL subform including 5% of all CTCL cases. [2,3] The diagnosis of CTCL is based on a combination of clinical, histopathological and molecular features and is challenging especially in early stages of the disease. As a result, the median time between initial symptoms and primary diagnosis is 3-4 years. [4,5] The disease progression is greatly diverse between patients. For about two-third of MF patients, the disease stays indolent in early stages with limited skin lesions and a normal life expectancy. Around 6% per year progress to advanced stages with tumors on the skin

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“…The IPH4102, a humanized monoclonal antibody directed against the KIR3DL2 cell receptor (CD158K) has been also proposed. Finally, histone deacetylase (HDAC) inhibitors (romidepsin and vorinostat) and demethylating agents have demonstrated efficacy in inducing cell cycle arrest, differentiation and / or apoptosis of tumor cells [37][38][39][40][41].…”

Section: Therapiesmentioning

confidence: 99%

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in Elderly, the Importance of a Sport Activity Training

Sica¹,

Vitiello²,

Ronchi³

et al. 2019

Preprint

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： PcALCL mainly concerns elderly patients. It is a large CD30+ T-cell neoplasm composed of large cells with anaplastic, pleomorphic or immunoblastic morphology, with exclusively cutaneous onset and localization. The clinical course of pcALCL is predominantly indolent. Most elderly patients with lymphoma tend to have a sedentary lifestyle, which has a negative effect on their quality of life (QoL) and on their survival. Several studies indicate that exercise has a positive impact on QoL because it reduces peak oxygen consumption, improves physical capacity, increases self-esteem, reduces accumulated stress and promotes relaxation. Therefore, particularly in indolent lymphomas, it is necessary to indicate a program of physical activity to be practiced systematically. The complete surgical excision and local radiotherapy are the first line gold standard in pcALCL with solitary lesion.

show abstract

Antibody-Based Therapies for Cutaneous T-Cell Lymphoma

Cited by 22 publications

References 41 publications

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training

Molecular pathogenesis of cutaneous lymphoma–Future directions

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in Elderly, the Importance of a Sport Activity Training

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