Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training

Abstract

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is part of a spectrum of cutaneous CD30+ lymphoproliferative disease that also includes lymphomatoid papulosis. It often occurs in elderly patients, presenting at a median age of 60 years, although it may occur at any age. It is a CD30+ T-cell neoplasm composed of large cells with anaplastic, pleomorphic, or immunoblastic morphology, with exclusively cutaneous onset and localization. The clinical course of pcALCL is predominantly indolent. Most elderly patients with lymphoma tend to have a sedentary lifestyle, which has a negative effect on their quality of life (QoL) and survival. Several studies indicate that exercise has a positive impact on QoL because it reduces peak oxygen consumption, improves physical capacity, increases self-esteem, reduces accumulated stress, and promotes relaxation. Therefore, particularly in indolent lymphomas, it is necessary to indicate a program of physical activity to be practiced systematically. Complete surgical excision and local radiotherapy are the first line gold standard in pcALCL with a solitary lesion.

Primary Cutaneous B-Cell Lymphomas: An Update

“…In patients with single lesion, local radiation therapy is the choice with the possible addition of R-CHOP. Like for all lymphomas, before starting each chemotherapy protocol, it is good practice to search for HCVAb, HBsAg, and HBcAb to check for any viral reactivation and prevent it with the indicated prophylaxis (28)(29)(30)(31)(32). Patients with generalized lesions are treated as in nodal DLBCLs.…”

The impact of the SARS‐CoV‐2 infection, with special reference to the hematological setting

“…5 These example data, together with the data from few small other studies, suggest that the exposure of patients with cancer to SARS-CoV-2 is very risky, and that every possible precaution must be put in place to prevent this from happening. [6][7][8][9][10][11][12] These considerations also apply to the context of bone marrow transplantation. [13][14][15] We have prepared this review article for all doctors who have not had the opportunity to investigate the different aspects of COVID-19 sufficiently, including young infectious disease specialists, hematologists, and general practitioners, who for more than one reason may meet patients with COVID-19, having to make a first diagnosis and the first decisions about it.…”

An Anecdotal Case Report of Chronic Lymphatic Leukemia with del(11q) Treated with Ibrutinib: Artificial Nourishment and Physical Activity Program

“…The diagnosis and management of CLL impact quality of life (QoL) [37], and also the sedentary lifestyle of the majority of cancer patients play a negative effect on QoL [5,6,[37][38][39][40][41][42] and on their survival [11]. However, randomized studies have shown the substantial improvement in QoL of…”

“…The diagnosis and management of CLL impact quality of life (QoL) [37], and also the sedentary lifestyle of the majority of cancer patients play a negative effect on QoL [5,6,[37][38][39][40][41][42] and on their survival [11]. However, randomized studies have shown the substantial improvement in QoL of cancer patients due to an adequate program of physical activity [23][24][25]34] and impact the cancer survival [7], since it reduces the peak oxygen consumption, improves physical capacity, increases self-esteem, reduces accumulated stress, and promotes relaxation [8,11].…”