Antibodies in Infants Born to Mothers With COVID-19 Pneumonia

Zeng, Hui; Xu, Chen; Fan, Jie; Tang, Yueting; Deng, Qiaoling; Zhang, Wei; Long, Xinghua

doi:10.1001/jama.2020.4861

Cited by 701 publications

(960 citation statements)

References 3 publications

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“…According to the information provided regarding to the intent to use and regulatory status; no current label requirement was found for 46 tests (20.4%) and most of the Finally, we reviewed the literature published until april 5th 2020, where they used serological assays listed in the Supplementary Table 2 . From 15 articles, 4 kits were used among those publications (9,11,13,14). 7 All rights reserved.…”

Section: Resultsmentioning

confidence: 99%

Immunological assays for SARS-CoV-2: an analysis of available commercial tests to measure antigen and antibodies

González

Shelton

Díaz-Vallejo

et al. 2020

Preprint

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The rapid spread of SARS-CoV-2 coronavirus infection has led to the development of molecular and serologic tests in a short period of time. While tests such as RT-PCR have applications in the immediate diagnosis revealing the presence of the virus, serological tests can be used to determine previous exposure to the virus and complement acute diagnosis. Antibody production can occur as early as 5 days post-infection. Both IgM and IgG specific anti-SARS-COV-2 antibodies can be a useful tool to test faster and larger groups of individuals. The objective of this study was to carry out a review of the different serological tests offered to detect antigen or antibodies against SARS-CoV-2. This information should be useful for decision takers in different countries to choose a test according to their needs. Based on web pages that listed serological assays, we found 226 coming from 20 countries, the majority are indirect tests for specific antibodies detection (n 180) and use immunochromatography methods (n 110) with samples coming from blood-derived products (n 105). Measuring IgM/IgG at the same time (n 112) and a procedure time of <20 min (n 83) are the most common. The overall average sensitivity was 91.8% and specificity was 97%. Most of the tests are currently for in vitro diagnosis (IVD).This information gathered could change day by day due to the expedite process of production and emergency of authorization use.

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Section: Resultsmentioning

confidence: 99%

Immunological assays for SARS-CoV-2: an analysis of available commercial tests to measure antigen and antibodies

González

Shelton

Díaz-Vallejo

et al. 2020

Preprint

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“…All the studies adopting a descriptive cross-sectional design (42%) [16,17,18,19,20] were conducted in China and addressed 40 (33.6%) pregnant women infected with COVID-19, predominantly in the third trimester of pregnancy (95%), presenting at least one prior comorbidity (60%). Fever at admission (58%) and postpartum (28%), cough (20%), and dyspnea (13%) were the primary clinical findings.…”

Section: Resultsmentioning

confidence: 99%

“…Other laboratory tests were performed for 27 pregnant women, namely: C-reactive protein [17,18,20], lymphocytopenia [17,18,20], neutrophilia [18,20], leukocytosis [17,20], immunoglobulins G and M [19], and interleukin 6 [19].…”

Section: Resultsmentioning

confidence: 99%

“…They tested positive and were hospitalized. Such a fact reinforces the need to follow recommendations provided by the Centers for Disease Control and Prevention (CDC) and the WHO to testing risk groups in contact with those diagnosed with COVID-19 [19,20,21,22,23,24,25,26,27,28,29,30], though this approach may not be feasible in some contexts where there is a shortage of tests.…”

Section: Discussionmentioning

confidence: 99%

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Effects of COVID-19 infection during pregnancy and neonatal prognosis: what is the evidence?

Sousa

Carvalho

Oliveira

et al. 2020

Preprint

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Background:Little is known about how COVID-19 infection affects pregnant women, as well as about the possibility of vertical transmission or that of premature labor. Thus, this study's objective was to identify existing evidence to directive public policies.Method: Systematic literature review assessing papers published in the most comprehensive databases in the field of health.Results: 12 papers were eligible. A total of 119 pregnant women aged between 22 and 42 years old and between the 12th and 41st weeks were analyzed; 90 children were born. Most : medRxiv preprint pregnant women acquired the infection in the third trimester of pregnancy, 97.4% were diagnosed before hospitalization based on signs and symptoms. There was no maternal death and no vertical transmission was confirmed.Conclusions: pregnant women must be cautious and vigilant because their exposure to the virus, even if at the end of a pregnancy, has important repercussions, especially for the type of labor.

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“…Recently, a report from China described three infants with elevated serum levels of IgG and IgM antibodies for SARS-CoV-2 after birth. 12,13 The postnatal courses were benign and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal swabs, serum, vaginal secretions, and maternal breast milk were negative. Thus, in the light of negative RT-PCR results and given that IgM false positives results are not uncommon, and that the decline of IGM levels were very unusual in comparison with other congenital https://doi.org/10.1016/j.jped.2020.04.002 0021-7557/© 2020 Sociedade Brasileira infections, the possibility of maternal-infant transmission is difficult to ascertain.…”

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confidence: 99%

Neonatal COVID-19: little evidence and the need for more information

Procianoy¹,

Silveira²,

Manzoni³

et al. 2020

Jornal de Pediatria

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Based on available reports (up to the writing of this editorial) and on scientific data reported by China, Italy, and the United States, newborn infants appear to be significantly less affected by COVID-19 than adults. 1---3 However, the lack of high-quality evidence for this situation and the steadfast pace of new and conflicting information has been an overall challenge to all medical specialties, including neonatal intensive care. In reality, the current knowledge on neonatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. Therefore, several questions remain unanswered, while at the same time the neonatal community needs to take action. Not surprisingly, this has caused significant stress amongst neonatal health care providers.All over the world, a number of important groups have been diligently working on the development of protocols ଝ Please cite this article as: Procianoy RS, Silveira RC, Manzoni P, Sant'Anna G. Neonatal COVID-19: little evidence and the need for more information. J Pediatr (Rio J). 2020. https://doi.

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Antibodies in Infants Born to Mothers With COVID-19 Pneumonia

Abstract: Author Contributions: Drs Liu and Yang had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Dong and Tian contributed equally to the study. Drs Liu and Yang contributed equally as senior authors.

Cited by 701 publications

References 3 publications

Immunological assays for SARS-CoV-2: an analysis of available commercial tests to measure antigen and antibodies

Immunological assays for SARS-CoV-2: an analysis of available commercial tests to measure antigen and antibodies

Effects of COVID-19 infection during pregnancy and neonatal prognosis: what is the evidence?

Neonatal COVID-19: little evidence and the need for more information

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