Antibiotics in Lichens

Vartia, K.

doi:10.1016/b978-0-12-044950-7.50022-2

Cited by 135 publications

(96 citation statements)

References 23 publications

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“…They were reported to be effective in the treatment some diseases such as tuberculosis (Vartia 1973), hemorrhoids and dysentery (Dülger et al 1998). Furthermore, antibacterial (Kosanić & Ranković 2011;Kosanić et al 2013Kosanić et al , 2014Grujičić et al 2014), antiviral (Karagöz & Aslan 2005), antiinflammatory (Süleyman et al 2002(Süleyman et al , 2003Halici et al 2005;Odabasoglu et al 2006), antioxidant (Gülçin et al 2002;Aslan et al 2006;Paudel et al 2012;Ghate et al 2013;Grujičić et al 2014), antimutagenic and antigenotoxic activities (Zeytinoglu et al 2008;Agar et al 2010;Alpsoy et al 2011;Kotan et al 2011) of the lichens were reported.…”

Section: Introductionmentioning

confidence: 99%

In vitroantitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells

Emsen

Aslan

Toğar

et al. 2015

Pharmaceutical Biology

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Context Since methods utilised in the treatment of glioblastoma multiforme (GBM) are inadequate and have too many side effects, usage of herbal products in the treatment process comes into prominence. Lichens are symbiotic organisms used for medicinal purposes for many years. There are various anticancer treatments about components of two lichen species used in the present study. Objective Antitumor potential of three lichen secondary metabolites including olivetoric acid (OLA) and physodic acid (PHA) isolated from Pseudevernia furfuracea (L.) Zopf (Parmeliaceae) and psoromic acid (PSA) isolated from Rhizoplaca melanophthalma (DC.) Leuckert (Lecanoraceae) were investigated on human U87MG-GBM cell lines and primary rat cerebral cortex (PRCC) cells for the first time. Materials and methods PRCC cells used as healthy brain cells were obtained from SpragueDawley rats. The treatments were carried out on the cells cultured for 48 h. Cytotoxic effects of different concentrations (2.5, 5, 10, 20 and 40 mg/L) of metabolites on the cells were determined via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) analyses. Total antioxidant capacity (TAC) and total oxidant status (TOS) parameters were used for assessing oxidative alterations. Oxidative DNA damage potentials of metabolites were investigated via evaluating 8-hydroxy-2 0 -deoxyguanosine (8-OH-dG) levels. Results Median inhibitory concentration (IC 50 ) values of OLA, PHA and PSA were 125.71, 698.19 and 79.40 mg/L for PRCC cells and 17.55, 410.72 and 56.22 mg/L for U87MG cells, respectively. It was revealed that cytotoxic effects of these metabolites showed positive correlation with concentration, LDH activity and oxidative DNA damage. Discussion and conclusion The present findings obtained in this study revealed that primarily OLA and then PSA had high potential for use in the treatment of GBM. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

In vitroantitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells

Emsen

Aslan

Toğar

et al. 2015

Pharmaceutical Biology

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“…The lichens have also antioxidant, antimicrobial and anticancer properties [5,6] . It is documented that they effective in the treatment of tuberculosis [7] , hemorrhoids and dysentery [8] and also induce apoptosis in colon [9,10] and prostate cancers [11] . Lichen species are very common in Turkey.…”

Section: Introductionmentioning

confidence: 99%

Liken Ekstrelerinin Sağlıklı Ratlar Üzerindeki Etkileri ve Bu Ekstrelerin Diyabete Bağlı Çoklu Organ Yetmezliğinin Önlenmesinde Medikal Kullanımı

Çolak¹,

Geyikoğlu²,

Türkez³

et al. 2015

Kafkas Univ Vet Fak Derg

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In the present study, we firstly assessed Cetraria islandica and Pseudevernia furfuracae to avoid detrimental effects on multiple tissues of rats. Diabetes mellitus (DM) with the subsequent generation of oxidative stress represents a major risk factor for organs. The second aim of this study is to investigate whether administration of both lichens could prevent type 1 diabetes (T1D)-induced organ dysfunctions. During two weeks, both control and diabetic rats were treated with aqueous lichen extracts. The metabolic changes were determined. On day 14, after animals were decapitated, required samples for biochemical and genetic analysis were collected. Oxidative damage of DNA was estimated by measuring the increase in 8-hydroxy-2'-deoxyguanosine formation. Biochemical parameters were used to observe and evaluate the functional changes in tissues. Experimental data showed that the increasing doses of lichens alone have not any detrimental effect on above parameters. Moreover, C. islandica decreased the diabetes-induced glucose and malondialdehyde (MDA) levels. Thus, it seemed that the antioxidant treatment has an important effect on the organ failure in ill rats. However, the protective effect of C. islandica was inadequate on diabetesinduced disorders and DNA damages. Lichens are a safe in the studied dose range but the power of C. islandica is limited because of intensive oxidative stress in essential organs of T1D rats. Keywords: Cetraria islandica, Pseudevernia furfuracae, Diabetes mellitus, Organ dysfunctions, Antioxidant capacity, 8-hydroxy-2'-deoxyguanosine Liken Ekstrelerinin Sağlıklı Ratlar Üzerindeki Etkileri ve Bu Ekstrelerin Diyabete Bağlı Çoklu Organ Yetmezliğinin Önlenmesinde Medikal Kullanımı ÖzetBu çalışmada, ilk olarak Cetraria islandica ve Pseudevernia furfuracae türü liken ekstraktlarının sıçanlara ait çeşitli dokular üzerine zararlı etkilerinin olup olmadığı değerlendirilmiştir. Diabetes mellitusa (DM) bağlı oksidatif stres, organlar için büyük bir risk faktörü oluşturmaktadır. Çalışmamızın ikinci bölümünde ise her iki liken ekstaktı uygulamasının tip 1 diyabet kaynaklı organ bozukluklarına karşı koruyucu olup olmadıklarını araştırılmıştır. İki hafta boyunca hem kontrol hem de diyabetli ratlara sulu liken ekstreleri uygulanmıştır. Süre sonunda metabolik değişimler belirlenmiştir. Ondördüncü günde, hayvanların yaşamları servikal dislokasyonla sonlandırıldıktan sonra biyokimya ve genetik çalışmalar için gerekli örnekler alınmıştır. DNA'nın oksidatif hasarı 8-hidroksi-2'-deoksiguanosin oluşumunda meydana gelen artış ölçülerek hesaplanmıştır. Biyokimyasal parametreler dokularda meydana gelen fonksiyon değişimlerinin gözlenmesi ve değerlendirilmesi için kullanılmıştır. Deney sonuçları tek başına uygulanan liken ekstraktlarının artan dozlarda herhangi bir zararlı etkiye sahip olmadığını göstermiştir. Ayrıca, C. islandica diyabete bağlı artan kan glikoz ve malondialdehit (MDA) seviyesini kısmen düşürmüştür. Antioksidan tedavinin hasta ratlarda organ yetmezliğine karşı fayda sağlayacağı düşünülme...

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“…Burkholder et al (1944) reported for the first time the presence of antibiotic substances in lichens. The lichens Cetraria islandica, Lobaria pulmonaria, and Cladonia species were known for treatment of pulmonary tuberculosis (Vartia, 1973).…”

Section: Introductionmentioning

confidence: 99%

Antimycobacterial Activity of Lichens

Gupta

Darokar

Saikia

et al. 2007

Pharmaceutical Biology

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Ethanol extracts of nine lichen species, namely Everniastrum cirrhatum (Fr.) Hale ex Sipman (Parmeliaceae), Flavoparmelia caperata (L) Hale (Parmeliaceae), Heterodermia leucomela (L) Poelt (Physciaceae), Lecanora flavidorufa Hue (Lecanoraceae), Leptogium pedicellatum P.M. Jorg (Collemataceae), Lobaria isidiosa (Bory) Trevisan (Stictaceae), Rimelia reticulata (Taylor) Hale and Fletcher (Parmeliaceae), Phaeophyscia hispidula (Ach.) Essl (Physciaceae), and Stereocaulon foliolosum Nyl. (Stereocaulaceae), were evaluated for antimycobacteral properties against Mycobacterium tuberculosis H 37 Rv and H 37 Ra strains using the radiometric BACTEC method. Among the tested lichens, the virulent strain of M. tuberculosis H 37 Rv was found more susceptible to ethanol extract of F. caperata and H. leucomela (MIC 250 mg=mL). E. cirrhatum, R. reticulata, and S. foliolosum were found active at the concentration of 500 mg=mL. L. isidiosa, L. pedicellatum, P. hispidula, and L. flavidorufa did not exhibit activity at the maximum tested concentration of 1000 mg=mL.

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Antibiotics in Lichens

Cited by 135 publications

References 23 publications

In vitroantitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells

In vitroantitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells

Liken Ekstrelerinin Sağlıklı Ratlar Üzerindeki Etkileri ve Bu Ekstrelerin Diyabete Bağlı Çoklu Organ Yetmezliğinin Önlenmesinde Medikal Kullanımı

Antimycobacterial Activity of Lichens

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