Antimycobacterial Activity of Lichens

Gupta, Vivek Kumar; Darokar, Mahendra P.; Saikia, Dharmendra; Pal, Anirban; Fatima, Atiya

doi:10.1080/13880200701213088

Cited by 29 publications

(21 citation statements)

References 14 publications

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“…However, GC-MS gave good results with mono-aromatic compounds in an oak moss absolute fraction, 11 identification and quantification of atraric acid, 12 and the fatty acids of the genus Collema lichens. 13 Only HPLC fingerprints of various lichen species 5 have been exploited to date, whereas, to the best of our knowledge, there have been no attempts at …”

Section: Introductionmentioning

confidence: 99%

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Volatile constituents of selected Parmeliaceae lichens

Stojanovic

Radulović

Mitrović

et al. 2011

JSCS

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The acetone soluble fraction of the methanol extracts of Parmeliaceae lichens: Hypogymnia physodes, Evernia prunastri and Parmelia sulcata, growing on the same host tree (Prunus domestica) and at the same locality was analyzed for the first time by GC and GC-MS. The major identified components were olivetol (33.5 % of the H. physodes extract), atraric acid (30.1 and 30.3 % of the E. prunastri and P. sulcata extracts, respectively), orcinol (25.0 % of the E. prunastri extract), vitamin E (24.7 % of the P. sulcata extract) and olivetonide (15.7 % of the H. physodes extract). Even though all the identified compounds are known, a number of them were found for the first time in the examined lichens, i.e., orcinol monomethyl ether (H. physodes), orcinol, atranol, lichesterol, ergosterol (H. physodes and P. sulcata), methyl haematommate, atraric acid, olivetol, vitamin E (H. physodes and P. sulcata) and β-sitosterol (P. sulcata).

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Section: Introductionmentioning

confidence: 99%

“…5,6 Gupta et al 5 developed an HPLC method with photodiode array detection for the determination of methyl β-orcinolcarboxylate and ethyl haematommate in the thalii of various lichen species.…”

Section: Introductionmentioning

confidence: 99%

Volatile constituents of selected Parmeliaceae lichens

Stojanovic

Radulović

Mitrović

et al. 2011

JSCS

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“…Out of all lichen species under investigation, some of the selected species have already been investigated for antimicrobial or enzyme inhibitory activities [22, 23], but little is known about their antioxidant capacities. In addition, as an approach to their anticancer potential, we aimed to determine their cytotoxic effects on two human cancer cell lines (the hepatocellular carcinoma-derived HepG2 and the breast adenocarcinoma MCF-7 cell line).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antioxidant Capacities and Cytotoxic Effects of Ten Parmeliaceae Lichen Species

Fernández-Moriano

González-Burgos

Divakar³

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Parmeliaceae represents the largest and widespread family of lichens and includes species that attract much interest regarding pharmacological activities, due to their production of unique secondary metabolites. The current work aimed to investigate the in vitro antioxidant and cytotoxic activities of the methanol extracts of ten Parmeliaceae species, collected in different continents. Methanol extraction afforded high phenolic content in the extracts. The antioxidant activity displayed by lichens was evaluated through chemical assays, such as the ORAC (Oxygen Radical Absorbance Capacity) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities and the ferric reducing antioxidant power (FRAP). A moderately positive correlation was found between the phenolic content and the antioxidant properties for all the species: R: 0.7430 versus ORAC values, R: 0.7457 versus DPPH scavenging capacity, and R: 0.7056 versus FRAP reducing power. The methanol extract of Flavoparmelia euplecta exhibited the highest ORAC value, the extract of Myelochroa irrugans showed the maximum DPPH scavenging capacity, and Hypotrachyna cirrhata methanol extract demonstrated the highest reducing power. Further, the cytotoxic activity of the ten species was investigated on the human cancer cell lines HepG2 and MCF-7; Myelochroa irrugans exhibited the highest anticancer potential. The pharmacological activities shown here could be attributed to their phytochemical constituents.

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“…Many of the interesting lichen substances are aromatic polyketides [5] with marked antioxidative properties [6] conferring: allelopathy properties against bacteria [7][8][9] and fungi [10,11] and enabling specific pharmacological applications as photoprotection [12,13] cardioprotection [14] neuroprotection [15] antiviral [16] and antitumoral applications [9,17] in mammals by modulating intracellular concentration of hydrogen peroxide [18]. While lichen substances have interest by the properties exhibited, these substances have had importance in lichen determination by identifying lichen substances as a character in chemotaxonomy.…”

Section: Introductionmentioning

confidence: 99%

Chemosyndrome Variation in Mycobiont Culture and Thallus of <em>Parmelina carporrhizans</em> and <em>Parmelina quercina</em>

Alors¹,

Divakar²,

Anjuli³

et al. 2017

Preprint

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Abstract:We cultured Parmelina carporrhizans and P. quercina in Corn Meal Agar and 0.2% glucose Malt Yeast Agar for 160 days. Chemosyndrome of natural thalli and mycobiont cultures were analyzed by HPLC. Lecanoric acid, atranorin, chloratranorin and ergosterol were detected in P. carporrhizans thalli, while lecanoric acid, chloratranorin and aliphates were found in P. quercina thalli. The secondary methabolites pattern between thalli and mycobiont culture was completely different in both species. Both species secreted the phenalenone myeloconone C in culture media and was also detected in P. quercina mycobiont aggregates. Interestingly, the phenolic compounds produced by the mycobiont culture of P. carporrhizans are related to those produced by natural thallus by the same biosynthetic pathway, while the chemosyndrome of P. quercina mycobiont implies switch of biosynthetic pathway from acetate-polymalonate pathway to shikimic acid pathway, with pulvinic acid as major compound of mycobiont culture. The role of Myelochonone C, confluentic acid and pulvinic acid produced by mycobiont culture is discussed as possible adaptive vantage in field as photoprotective agent or as byproduct result of stressing artificial culture conditions.

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Antimycobacterial Activity of Lichens

Cited by 29 publications

References 14 publications

Volatile constituents of selected Parmeliaceae lichens

Volatile constituents of selected Parmeliaceae lichens

Evaluation of the Antioxidant Capacities and Cytotoxic Effects of Ten Parmeliaceae Lichen Species

Chemosyndrome Variation in Mycobiont Culture and Thallus of <em>Parmelina carporrhizans</em> and <em>Parmelina quercina</em>

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